| Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification ML Maeder, S Thibodeau-Beganny, A Osiak, DA Wright, RM Anthony, ... Molecular cell 31 (2), 294-301, 2008 | 964 | 2008 |
| High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases F Chen, SM Pruett-Miller, Y Huang, M Gjoka, K Duda, J Taunton, ... Nature methods 8 (9), 753-755, 2011 | 648 | 2011 |
| Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells J Zou, ML Maeder, P Mali, SM Pruett-Miller, S Thibodeau-Beganny, ... Cell stem cell 5 (1), 97-110, 2009 | 622 | 2009 |
| A survey of validation strategies for CRISPR-Cas9 editing MF Sentmanat, ST Peters, CP Florian, JP Connelly, SM Pruett-Miller Scientific reports 8 (1), 888, 2018 | 337 | 2018 |
| Discovery of a proteinaceous cellular receptor for a norovirus RC Orchard, CB Wilen, JG Doench, MT Baldridge, BT McCune, YCJ Lee, ... Science 353 (6302), 933-936, 2016 | 275 | 2016 |
| Base editing of haematopoietic stem cells rescues sickle cell disease in mice GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ... Nature 595 (7866), 295-302, 2021 | 231 | 2021 |
| Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels SM Pruett-Miller, DW Reading, SN Porter, MH Porteus PLoS genetics 5 (2), e1000376, 2009 | 176 | 2009 |
| Germline genetic IKZF1 variation and predisposition to childhood acute lymphoblastic leukemia ML Churchman, M Qian, G Te Kronnie, R Zhang, W Yang, H Zhang, ... Cancer cell 33 (5), 937-948. e8, 2018 | 175 | 2018 |
| Comparison of zinc finger nucleases for use in gene targeting in mammalian cells SM Pruett-Miller, JP Connelly, ML Maeder, JK Joung, MH Porteus Molecular Therapy 16 (4), 707-717, 2008 | 159 | 2008 |
| Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity B Prinzing, CC Zebley, CT Petersen, Y Fan, AA Anido, Z Yi, P Nguyen, ... Science translational medicine 13 (620), eabh0272, 2021 | 147 | 2021 |
| ULK1 and ULK2 regulate stress granule disassembly through phosphorylation and activation of VCP/p97 B Wang, BA Maxwell, JH Joo, Y Gwon, J Messing, A Mishra, TI Shaw, ... Molecular cell 74 (4), 742-757. e8, 2019 | 140 | 2019 |
| Genome editing of HBG1 and HBG2 to induce fetal hemoglobin JY Métais, PA Doerfler, T Mayuranathan, DE Bauer, SC Fowler, MM Hsieh, ... Blood advances 3 (21), 3379-3392, 2019 | 137 | 2019 |
| CRIS. py: a versatile and high-throughput analysis program for CRISPR-based genome editing JP Connelly, SM Pruett-Miller Scientific reports 9 (1), 4194, 2019 | 124 | 2019 |
| Nuclease-mediated gene editing by homologous recombination of the human globin locus RA Voit, A Hendel, SM Pruett-Miller, MH Porteus Nucleic acids research 42 (2), 1365-1378, 2014 | 120 | 2014 |
| Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome AJ Cohen, A Saiakhova, O Corradin, JM Luppino, K Lovrenert, CF Bartels, ... Nature communications 8 (1), 14400, 2017 | 114 | 2017 |
| The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development S Kesavardhana, RKS Malireddi, AR Burton, SN Porter, P Vogel, ... Journal of Biological Chemistry 295 (24), 8325-8330, 2020 | 103 | 2020 |
| Accurate genomic variant detection in single cells with primary template-directed amplification V Gonzalez-Pena, S Natarajan, Y Xia, D Klein, R Carter, Y Pang, ... Proceedings of the National Academy of Sciences 118 (24), e2024176118, 2021 | 102 | 2021 |
| ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection R Karki, SJ Lee, R Mall, N Pandian, Y Wang, BR Sharma, RKS Malireddi, ... Science immunology 7 (74), eabo6294, 2022 | 98 | 2022 |
| High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs K Duda, LA Lonowski, M Kofoed-Nielsen, A Ibarra, CM Delay, Q Kang, ... Nucleic acids research 42 (10), e84-e84, 2014 | 97 | 2014 |
| MYCN amplification and ATRX mutations are incompatible in neuroblastoma M Zeineldin, S Federico, X Chen, Y Fan, B Xu, E Stewart, X Zhou, J Jeon, ... Nature communications 11 (1), 913, 2020 | 94 | 2020 |
