| Illuminating G-protein-coupling selectivity of GPCRs A Inoue, F Raimondi, FMN Kadji, G Singh, T Kishi, A Uwamizu, Y Ono, ... Cell 177 (7), 1933-1947. e25, 2019 | 418 | 2019 |
| Lack of beta-arrestin signaling in the absence of active G proteins M Grundmann, N Merten, D Malfacini, A Inoue, P Preis, K Simon, ... Nature communications 9 (1), 341, 2018 | 365 | 2018 |
| Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis TJ Cahill III, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ... Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017 | 363 | 2017 |
| Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK M O’Hayre, K Eichel, S Avino, X Zhao, DJ Steffen, X Feng, K Kawakami, ... Science signaling 10 (484), eaal3395, 2017 | 210 | 2017 |
| Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors S Pandey, P Kumari, M Baidya, R Kise, Y Cao, H Dwivedi-Agnihotri, ... Molecular cell 81 (22), 4605-4621. e11, 2021 | 72 | 2021 |
| Heterotrimeric G protein subunit Gαq is a master switch for Gβγ-mediated calcium mobilization by Gi-coupled GPCRs EM Pfeil, J Brands, N Merten, T Vögtle, M Vescovo, U Rick, IM Albrecht, ... Molecular cell 80 (6), 940-954. e6, 2020 | 67 | 2020 |
| Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes Y Hisano, M Kono, A Cartier, E Engelbrecht, K Kano, K Kawakami, ... Journal of Experimental Medicine 216 (7), 1582-1598, 2019 | 54 | 2019 |
| Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias K Kawakami, M Yanagawa, S Hiratsuka, M Yoshida, Y Ono, M Hiroshima, ... Nature communications 13 (1), 487, 2022 | 53 | 2022 |
| Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism Z Xu, T Ikuta, K Kawakami, R Kise, Y Qian, R Xia, MX Sun, A Zhang, ... Nature chemical biology 18 (3), 281-288, 2022 | 49 | 2022 |
| Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation M Baidya, P Kumari, H Dwivedi‐Agnihotri, S Pandey, M Chaturvedi, ... EMBO reports 21 (9), e49886, 2020 | 49 | 2020 |
| Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits CD Arveseth, JT Happ, DS Hedeen, JF Zhu, JL Capener, D Klatt Shaw, ... PLoS biology 19 (4), e3001191, 2021 | 47 | 2021 |
| Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics J Janetzko, R Kise, B Barsi-Rhyne, DH Siepe, FM Heydenreich, ... Cell 185 (24), 4560-4573. e19, 2022 | 43 | 2022 |
| Agonist-induced formation of unproductive receptor-G12 complexes N Okashah, SC Wright, K Kawakami, S Mathiasen, J Zhou, S Lu, ... Proceedings of the National Academy of Sciences 117 (35), 21723-21730, 2020 | 37 | 2020 |
| N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand A Ogawa, C Nagiri, W Shihoya, A Inoue, K Kawakami, S Hiratsuka, J Aoki, ... Molecular Cell 81 (4), 659-674. e7, 2021 | 34 | 2021 |
| Endogenous ligand recognition and structural transition of a human PTH receptor K Kobayashi, K Kawakami, T Kusakizako, H Miyauchi, A Tomita, ... Molecular Cell 82 (18), 3468-3483. e5, 2022 | 27 | 2022 |
| A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias E Sergeev, AH Hansen, D Bolognini, K Kawakami, T Kishi, J Aoki, T Ulven, ... Scientific Reports 7 (1), 13741, 2017 | 18 | 2017 |
| Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody M Baidya, M Chaturvedi, H Dwivedi-Agnihotri, A Ranjan, D Devost, ... Nature Communications 13 (1), 4634, 2022 | 14 | 2022 |
| Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor J Heng, Y Hu, G Pérez-Hernández, A Inoue, J Zhao, X Ma, X Sun, ... Nature Communications 14 (1), 2005, 2023 | 12 | 2023 |
| Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation J Liang, A Inoue, T Ikuta, R Xia, N Wang, K Kawakami, Z Xu, Y Qian, ... Nature Communications 14 (1), 1012, 2023 | 11 | 2023 |
| Class B1 GPCR activation by an intracellular agonist K Kobayashi, K Kawakami, T Kusakizako, A Tomita, M Nishimura, ... Nature 618 (7967), 1085-1093, 2023 | 10 | 2023 |
