David Vocadlo
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
SA Yuzwa, MS Macauley, JE Heinonen, X Shan, RJ Dennis, Y He, ...
Nature chemical biology 4 (8), 483-490, 2008
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
DJ Vocadlo, GJ Davies, R Laine, SG Withers
Nature 412 (6849), 835-838, 2001
A chemical approach for identifying O-GlcNAc-modified proteins in cells
DJ Vocadlo, HC Hang, EJ Kim, JA Hanover, CR Bertozzi
Proceedings of the National Academy of Sciences 100 (16), 9116-9121, 2003
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
SA Yuzwa, X Shan, MS Macauley, T Clark, Y Skorobogatko, K Vosseller, ...
Nature chemical biology 8 (4), 393-399, 2012
O-GlcNAcase Uses Substrate-assisted Catalysis: Kineticanalysis And Development Of Highly Selective Mechanism-Inspiredinhibitors
MS Macauley, GE Whitworth, AW Debowski, D Chin, DJ Vocadlo
Journal of Biological Chemistry 280 (27), 25313-25322, 2005
Mechanistic insights into glycosidase chemistry
DJ Vocadlo, GJ Davies
Current opinion in chemical biology 12 (5), 539-555, 2008
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway
CM Ferrer, TP Lynch, VL Sodi, JN Falcone, LP Schwab, DL Peacock, ...
Molecular cell 54 (5), 820-831, 2014
Crystallographic evidence for substrate-assisted catalysis in a bacterial β-hexosaminidase
BL Mark, DJ Vocadlo, S Knapp, BL Triggs-Raine, SG Withers, ...
Journal of Biological Chemistry 276 (13), 10330-10337, 2001
NAG-thiazoline, an N-acetyl-β-hexosaminidase inhibitor that implicates acetamido participation
S Knapp, D Vocadlo, Z Gao, B Kirk, J Lou, SG Withers
Journal of the American Chemical Society 118 (28), 6804-6805, 1996
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells
TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng, DJ Vocadlo
Nature chemical biology 7 (3), 174-181, 2011
The emerging link between O-GlcNAc and Alzheimer disease
Y Zhu, X Shan, SA Yuzwa, DJ Vocadlo
Journal of Biological Chemistry 289 (50), 34472-34481, 2014
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells
Z Ma, DJ Vocadlo, K Vosseller
Journal of Biological Chemistry 288 (21), 15121-15130, 2013
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)
DAR Sinclair, M Syrzycka, MS Macauley, T Rastgardani, I Komljenovic, ...
Proceedings of the National Academy of Sciences 106 (32), 13427-13432, 2009
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
SA Yuzwa, DJ Vocadlo
Chemical Society Reviews 43 (19), 6839-6858, 2014
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
RJ Dennis, EJ Taylor, MS Macauley, KA Stubbs, JP Turkenburg, SJ Hart, ...
Nature structural & molecular biology 13 (4), 365-371, 2006
Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology
TM Gloster, DJ Vocadlo
Nature chemical biology 8 (8), 683-694, 2012
HCF-1 is cleaved in the active site of O-GlcNAc transferase
MB Lazarus, J Jiang, V Kapuria, T Bhuiyan, J Janetzko, WF Zandberg, ...
Science 342 (6163), 1235-1239, 2013
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
GE Whitworth, MS Macauley, KA Stubbs, RJ Dennis, EJ Taylor, GJ Davies, ...
Journal of the American Chemical Society 129 (3), 635-644, 2007
Structural snapshots of the reaction coordinate for O-GlcNAc transferase
MB Lazarus, J Jiang, TM Gloster, WF Zandberg, GE Whitworth, ...
Nature chemical biology 8 (12), 966-968, 2012
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