Manthena V. Varma
Manthena V. Varma
Pharmacokinetics, dynamics and metabolism
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P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement
MVS Varma, Y Ashokraj, CS Dey, R Panchagnula
Pharmacological research 48 (4), 347-359, 2003
4312003
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo
MVS Varma, R Panchagnula
European journal of pharmaceutical sciences 25 (4-5), 445-453, 2005
3052005
Development of a new permeability assay using low‐efflux MDCKII cells
L Di, C Whitney‐Pickett, JP Umland, H Zhang, X Zhang, DF Gebhard, ...
Journal of pharmaceutical sciences 100 (11), 4974-4985, 2011
1902011
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination
MVS Varma, RS Obach, C Rotter, HR Miller, G Chang, SJ Steyn, ...
Journal of medicinal chemistry 53 (3), 1098-1108, 2010
1772010
Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport
MVS Varma, K Sateesh, R Panchagnula
Molecular pharmaceutics 2 (1), 12-21, 2005
1552005
Factors affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems
MVS Varma, AM Kaushal, A Garg, S Garg
American Journal of drug delivery 2 (1), 43-57, 2004
1502004
Physicochemical determinants of human renal clearance
MVS Varma, B Feng, RS Obach, MD Troutman, J Chupka, HR Miller, ...
Journal of medicinal chemistry 52 (15), 4844-4852, 2009
1322009
Influence of micro-environmental pH on the gel layer behavior and release of a basic drug from various hydrophilic matrices
MVS Varma, AM Kaushal, S Garg
Journal of controlled release 103 (2), 499-510, 2005
1092005
Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS)
MV Varma, SJ Steyn, C Allerton, AF El-Kattan
Pharmaceutical research 32 (12), 3785-3802, 2015
1072015
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical …
JA Pfefferkorn, A Guzman-Perez, J Litchfield, R Aiello, JL Treadway, ...
Journal of medicinal chemistry 55 (3), 1318-1333, 2012
1022012
Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research
MVS Varma, S Khandavilli, Y Ashokraj, A Jain, A Dhanikula, A Sood, ...
Current drug metabolism 5 (5), 375-388, 2004
1022004
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery
MV Varma, I Gardner, SJ Steyn, P Nkansah, CJ Rotter, C Whitney-Pickett, ...
Molecular pharmaceutics 9 (5), 1199-1212, 2012
1012012
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions
MVS Varma, Y Lai, B Feng, J Litchfield, TC Goosen, A Bergman
Pharmaceutical research 29 (10), 2860-2873, 2012
992012
Targeting intestinal transporters for optimizing oral drug absorption
M V Varma, C M Ambler, M Ullah, C J Rotter, H Sun, J Litchfield, ...
Current drug metabolism 11 (9), 730-742, 2010
942010
Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability
MVS Varma, R Panchagnula
Journal of pharmaceutical sciences 94 (8), 1694-1704, 2005
912005
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
AC Rand, SSF Leung, H Eng, CJ Rotter, R Sharma, AS Kalgutkar, ...
MedChemComm 3 (10), 1282-1289, 2012
882012
pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1
MV Varma, CJ Rotter, J Chupka, KM Whalen, DB Duignan, B Feng, ...
Molecular pharmaceutics 8 (4), 1303-1313, 2011
832011
Mechanistic modeling to predict the transporter-and enzyme-mediated drug-drug interactions of repaglinide
MVS Varma, Y Lai, E Kimoto, TC Goosen, AF El-Kattan, V Kumar
Pharmaceutical research 30 (4), 1188-1199, 2013
792013
Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state
B Feng, JL LaPerle, G Chang, MVS Varma
Expert opinion on drug metabolism & toxicology 6 (8), 939-952, 2010
752010
Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers
P Sharma, MVS Varma, HPS Chawla, R Panchagnula
Il Farmaco 60 (11-12), 884-893, 2005
702005
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