| Rapamycin fed late in life extends lifespan in genetically heterogeneous mice DE Harrison, R Strong, ZD Sharp, JF Nelson, CM Astle, K Flurkey, ... nature 460 (7253), 392-395, 2009 | 4088 | 2009 |
| Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease P Spilman, N Podlutskaya, MJ Hart, J Debnath, O Gorostiza, D Bredesen, ... PloS one 5 (4), e9979, 2010 | 1127 | 2010 |
| Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-β, and Tau: effects on cognitive impairments A Caccamo, S Majumder, A Richardson, R Strong, S Oddo Journal of Biological Chemistry 285 (17), 13107-13120, 2010 | 972 | 2010 |
| Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice RA Miller, DE Harrison, CM Astle, JA Baur, AR Boyd, R De Cabo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2011 | 958 | 2011 |
| Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging H Van Remmen, Y Ikeno, M Hamilton, M Pahlavani, N Wolf, SR Thorpe, ... Physiological genomics 16 (1), 29-37, 2003 | 896 | 2003 |
| Rapamycin slows aging in mice JE Wilkinson, L Burmeister, SV Brooks, CC Chan, S Friedline, ... Aging cell 11 (4), 675-682, 2012 | 732 | 2012 |
| Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction RA Miller, DE Harrison, CM Astle, E Fernandez, K Flurkey, M Han, ... Aging cell 13 (3), 468-477, 2014 | 572 | 2014 |
| Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy FL Muller, W Song, Y Liu, A Chaudhuri, S Pieke-Dahl, R Strong, ... Free Radical Biology and Medicine 40 (11), 1993-2004, 2006 | 540 | 2006 |
| Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits S Majumder, A Richardson, R Strong, S Oddo PloS one 6 (9), e25416, 2011 | 449 | 2011 |
| Expression of heat shock protein 70 is altered by age and diet at the level of transcription AR Heydari, B Wu, R Takahashi, R Strong, A Richardson Molecular and cellular biology, 1993 | 401 | 1993 |
| Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males DE Harrison, R Strong, DB Allison, BN Ames, CM Astle, H Atamna, ... Aging cell 13 (2), 273-282, 2014 | 378 | 2014 |
| Rapamycin reverses elevated mTORC1 signaling in lamin A/C–deficient mice, rescues cardiac and skeletal muscle function, and extends survival FJ Ramos, SC Chen, MG Garelick, DF Dai, CY Liao, KH Schreiber, ... Science translational medicine 4 (144), 144ra103-144ra103, 2012 | 367 | 2012 |
| Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice R Strong, RA Miller, CM Astle, RA Floyd, K Flurkey, KL Hensley, ... Aging cell 7 (5), 641-650, 2008 | 336 | 2008 |
| Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer R Strong, RA Miller, A Antebi, CM Astle, M Bogue, MS Denzel, ... Aging cell 15 (5), 872-884, 2016 | 315 | 2016 |
| Late‐life rapamycin treatment reverses age‐related heart dysfunction JM Flynn, MN O'Leary, CA Zambataro, EC Academia, MP Presley, ... Aging cell 12 (5), 851-862, 2013 | 314 | 2013 |
| Age-related alterations in the rodent brain cholinergic system and behavior R Strong, P Hicks, L Hsu, RT Bartus, SJ Enna Neurobiology of Aging 1 (1), 59-63, 1980 | 281 | 1980 |
| Genetic mouse models of extended lifespan H Liang, EJ Masoro, JF Nelson, R Strong, CA McMahan, A Richardson Experimental gerontology 38 (11-12), 1353-1364, 2003 | 267 | 2003 |
| Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice BJ Smith, RA Miller, AC Ericsson, DC Harrison, R Strong, TM Schmidt BMC microbiology 19, 1-16, 2019 | 239 | 2019 |
| Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice R Strong, RA Miller, CM Astle, JA Baur, R De Cabo, E Fernandez, W Guo, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2013 | 235 | 2013 |
| WIN55, 212‐2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine mouse model of Parkinson’s disease DA Price, AA Martinez, A Seillier, W Koek, Y Acosta, E Fernandez, ... European Journal of Neuroscience 29 (11), 2177-2186, 2009 | 230 | 2009 |
