| A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity DJ Marchant, CL Bellac, TJ Moraes, SJ Wadsworth, A Dufour, GS Butler, ... Nature medicine 20 (5), 493-502, 2014 | 258 | 2014 |
| Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors D Georgiadis, F Beau, B Czarny, J Cotton, A Yiotakis, V Dive Circulation research 93 (2), 148-154, 2003 | 191 | 2003 |
| Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure− activity study S Vassiliou, A Mucha, P Cuniasse, D Georgiadis, K Lucet-Levannier, ... Journal of medicinal chemistry 42 (14), 2610-2620, 1999 | 141 | 1999 |
| Natural lactones and lactams: synthesis, occurrence and biological activity T Janecki John Wiley & Sons, 2013 | 131 | 2013 |
| Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs P Cuniasse, L Devel, A Makaritis, F Beau, D Georgiadis, M Matziari, ... Biochimie 87 (3-4), 393-402, 2005 | 131 | 2005 |
| Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ... Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013 | 125 | 2013 |
| Phosphinic peptides as zinc metalloproteinase inhibitors V Dive, D Georgiadis, M Matziari, A Makaritis, F Beau, P Cuniasse, ... Cellular and Molecular Life Sciences CMLS 61, 2010-2019, 2004 | 121 | 2004 |
| Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge D Georgiadis, A Yiotakis Bioorganic & medicinal chemistry 16 (19), 8781-8794, 2008 | 108 | 2008 |
| Phosphinic peptides: Synthetic approaches and biochemical evaluation as Zn-metalloprotease inhibitors A Yiotakis, D Georgiadis, M Matziari, A Makaritis, V Dive Current Organic Chemistry 8 (12), 1135-1158, 2004 | 108 | 2004 |
| The Structure of Testis Angiotensin-Converting Enzyme in Complex with the C Domain-Specific Inhibitor RXPA380, HR Corradi, I Chitapi, BT Sewell, D Georgiadis, V Dive, ED Sturrock, ... Biochemistry 46 (18), 5473-5478, 2007 | 107 | 2007 |
| Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1′ cavity L Devel, B Czarny, F Beau, D Georgiadis, E Stura, V Dive Biochimie 92 (11), 1501-1508, 2010 | 99 | 2010 |
| The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407 CS Anthony, HR Corradi, SLU Schwager, P Redelinghuys, D Georgiadis, ... Journal of biological chemistry 285 (46), 35685-35693, 2010 | 95 | 2010 |
| High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs M Akif, D Georgiadis, A Mahajan, V Dive, ED Sturrock, RE Isaac, ... Journal of molecular biology 400 (3), 502-517, 2010 | 94 | 2010 |
| Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain D Georgiadis, P Cuniasse, J Cotton, A Yiotakis, V Dive Biochemistry 43 (25), 8048-8054, 2004 | 93 | 2004 |
| A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing I Evnouchidou, J Birtley, S Seregin, A Papakyriakou, E Zervoudi, ... The Journal of Immunology 189 (5), 2383-2392, 2012 | 90 | 2012 |
| Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis L Chen, A Ridley, A Hammitzsch, MH Al-Mossawi, H Bunting, ... Annals of the rheumatic diseases 75 (5), 916-923, 2016 | 83 | 2016 |
| Selective angiotensin-converting enzyme C-domain inhibition is sufficient to prevent angiotensin I–induced vasoconstriction JHM van Esch, B Tom, V Dive, WW Batenburg, D Georgiadis, A Yiotakis, ... Hypertension 45 (1), 120-125, 2005 | 79 | 2005 |
| Diastereoselective solution and multipin‐based combinatorial array synthesis of a novel class of potent phosphinic metalloprotease inhibitors A Makaritis, D Georgiadis, V Dive, A Yiotakis Chemistry–A European Journal 9 (9), 2079-2094, 2003 | 77 | 2003 |
| Synthetic strategies towards naturally occurring tetronic acids AL Zografos, D Georgiadis Synthesis 2006 (19), 3157-3188, 2006 | 73 | 2006 |
| Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors N Jullien, A Makritis, D Georgiadis, F Beau, A Yiotakis, V Dive Journal of medicinal chemistry 53 (1), 208-220, 2010 | 71 | 2010 |
