| Enantioselective Intramolecular C H Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo JA McIntosh, PS Coelho, CC Farwell, ZJ Wang, JC Lewis, TR Brown, ... Angewandte Chemie 125 (35), 9479-9482, 2013 | 320 | 2013 |
| Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds JA McIntosh, MS Donia, EW Schmidt Natural product reports 26 (4), 537-559, 2009 | 320 | 2009 |
| Deep dive into machine learning models for protein engineering Y Xu, D Verma, RP Sheridan, A Liaw, J Ma, NM Marshall, J McIntosh, ... Journal of chemical information and modeling 60 (6), 2773-2790, 2020 | 212 | 2020 |
| Enantioselective enzyme-catalyzed aziridination enabled by active-site evolution of a cytochrome P450 CC Farwell, RK Zhang, JA McIntosh, TK Hyster, FH Arnold ACS central science 1 (2), 89, 2015 | 186 | 2015 |
| Enzyme-controlled nitrogen-atom transfer enables regiodivergent C–H amination TK Hyster, CC Farwell, AR Buller, JA McIntosh, FH Arnold Journal of the American Chemical Society 136 (44), 15505, 2014 | 179 | 2014 |
| Expanding P450 catalytic reaction space through evolution and engineering JA McIntosh, CC Farwell, FH Arnold Current opinion in chemical biology 19, 126-134, 2014 | 177 | 2014 |
| Using marine natural products to discover a protease that catalyzes peptide macrocyclization of diverse substrates J Lee, J McIntosh, BJ Hathaway, EW Schmidt Journal of the American Chemical Society 131 (6), 2122, 2009 | 170 | 2009 |
| Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer CC Farwell, JA McIntosh, TK Hyster, ZJ Wang, FH Arnold Journal of the American Chemical Society 136 (24), 8766, 2014 | 151 | 2014 |
| Enzymatic basis of ribosomal peptide prenylation in cyanobacteria JA McIntosh, MS Donia, SK Nair, EW Schmidt Journal of the American Chemical Society 133 (34), 13698, 2011 | 137 | 2011 |
| Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19 JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ... ACS Central Science, 2021 | 133 | 2021 |
| General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ... Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013 | 128 | 2013 |
| Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst JA McIntosh, CR Robertson, V Agarwal, SK Nair, GW Bulaj, EW Schmidt Journal of the American Chemical Society 132 (44), 15499, 2010 | 120 | 2010 |
| Origin and variation of tunicate secondary metabolites EW Schmidt, MS Donia, JA McIntosh, WF Fricke, J Ravel Journal of natural products 75 (2), 295, 2012 | 112 | 2012 |
| Marine molecular machines: heterocyclization in cyanobactin biosynthesis JA McIntosh, EW Schmidt ChemBioChem 11 (10), 1413-1421, 2010 | 98 | 2010 |
| Insights into heterocyclization from two highly similar enzymes JA McIntosh, MS Donia, EW Schmidt Journal of the American Chemical Society 132 (12), 4089, 2010 | 95 | 2010 |
| Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor KE Hernandez, H Renata, RD Lewis, SBJ Kan, C Zhang, J Forte, ... ACS Catalysis 6 (11), 7810-7813, 2016 | 90 | 2016 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 82 | 2022 |
| Recognition sequences and substrate evolution in cyanobactin biosynthesis D Sardar, E Pierce, JA McIntosh, EW Schmidt ACS synthetic biology 4 (2), 167, 2015 | 81 | 2015 |
| Structures of cyanobactin maturation enzymes define a family of transamidating proteases V Agarwal, E Pierce, J McIntosh, EW Schmidt, SK Nair Chemistry & biology 19 (11), 1411-1422, 2012 | 76 | 2012 |
| Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangements JA McIntosh, Z Lin, MD Tianero, EW Schmidt ACS chemical biology 8 (5), 877, 2013 | 68 | 2013 |
