John A. McIntosh
John A. McIntosh
Merck & Co., Inc., Rahway, NJ USA
Verified email at
Cited by
Cited by
Enantioselective Intramolecular C H Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
JA McIntosh, PS Coelho, CC Farwell, ZJ Wang, JC Lewis, TR Brown, ...
Angewandte Chemie 125 (35), 9479-9482, 2013
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds
JA McIntosh, MS Donia, EW Schmidt
Natural product reports 26 (4), 537-559, 2009
Enantioselective enzyme-catalyzed aziridination enabled by active-site evolution of a cytochrome P450
CC Farwell, RK Zhang, JA McIntosh, TK Hyster, FH Arnold
ACS central science 1 (2), 89, 2015
Expanding P450 catalytic reaction space through evolution and engineering
JA McIntosh, CC Farwell, FH Arnold
Current opinion in chemical biology 19, 126-134, 2014
Enzyme-controlled nitrogen-atom transfer enables regiodivergent C–H amination
TK Hyster, CC Farwell, AR Buller, JA McIntosh, FH Arnold
Journal of the American Chemical Society 136 (44), 15505, 2014
Using marine natural products to discover a protease that catalyzes peptide macrocyclization of diverse substrates
J Lee, J McIntosh, BJ Hathaway, EW Schmidt
Journal of the American Chemical Society 131 (6), 2122, 2009
Deep dive into machine learning models for protein engineering
Y Xu, D Verma, RP Sheridan, A Liaw, J Ma, NM Marshall, J McIntosh, ...
Journal of chemical information and modeling 60 (6), 2773-2790, 2020
Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer
CC Farwell, JA McIntosh, TK Hyster, ZJ Wang, FH Arnold
Journal of the American Chemical Society 136 (24), 8766, 2014
Enzymatic basis of ribosomal peptide prenylation in cyanobacteria
JA McIntosh, MS Donia, SK Nair, EW Schmidt
Journal of the American Chemical Society 133 (34), 13698, 2011
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ...
Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst
JA McIntosh, CR Robertson, V Agarwal, SK Nair, GW Bulaj, EW Schmidt
Journal of the American Chemical Society 132 (44), 15499, 2010
Origin and variation of tunicate secondary metabolites
EW Schmidt, MS Donia, JA McIntosh, WF Fricke, J Ravel
Journal of natural products 75 (2), 295, 2012
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ...
ACS Central Science, 2021
Marine molecular machines: heterocyclization in cyanobactin biosynthesis
JA McIntosh, EW Schmidt
ChemBioChem 11 (10), 1413-1421, 2010
Insights into heterocyclization from two highly similar enzymes
JA McIntosh, MS Donia, EW Schmidt
Journal of the American Chemical Society 132 (12), 4089, 2010
Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
KE Hernandez, H Renata, RD Lewis, SBJ Kan, C Zhang, J Forte, ...
ACS Catalysis 6 (11), 7810-7813, 2016
Recognition sequences and substrate evolution in cyanobactin biosynthesis
D Sardar, E Pierce, JA McIntosh, EW Schmidt
ACS synthetic biology 4 (2), 167, 2015
Structures of cyanobactin maturation enzymes define a family of transamidating proteases
V Agarwal, E Pierce, J McIntosh, EW Schmidt, SK Nair
Chemistry & biology 19 (11), 1411-1422, 2012
Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangements
JA McIntosh, Z Lin, MD Tianero, EW Schmidt
ACS chemical biology 8 (5), 877, 2013
Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE
SC Dodani, JKB Cahn, T Heinisch, S Brinkmann‐Chen, JA McIntosh, ...
ChemBioChem 15 (15), 2259-2267, 2014
The system can't perform the operation now. Try again later.
Articles 1–20