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Jan Mauer, Ph.D.
Jan Mauer, Ph.D.
Lab Head at Novartis Institutes for BioMedical Research (NIBR)
Bestätigte E-Mail-Adresse bei novartis.com
Titel
Zitiert von
Zitiert von
Jahr
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
J Mauer, X Luo, A Blanjoie, X Jiao, AV Grozhik, DP Patil, B Linder, ...
Nature 541 (7637), 371-375, 2017
9672017
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
J Mauer, B Chaurasia, J Goldau, MC Vogt, J Ruud, KD Nguyen, ...
Nature immunology 15 (5), 423-430, 2014
7412014
Obesity-induced CerS6-dependent C16: 0 ceramide production promotes weight gain and glucose intolerance
SM Turpin, HT Nicholls, DM Willmes, A Mourier, S Brodesser, ...
Cell metabolism 20 (4), 678-686, 2014
6152014
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
A Kleinridders, D Schenten, AC Könner, BF Belgardt, J Mauer, T Okamura, ...
Cell metabolism 10 (4), 249-259, 2009
5522009
Versatile functions for IL-6 in metabolism and cancer
J Mauer, JL Denson, JC Brüning
Trends in immunology 36 (2), 92-101, 2015
4572015
Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding
MC Vogt, L Paeger, S Hess, SM Steculorum, M Awazawa, B Hampel, ...
Cell 156 (3), 495-509, 2014
3652014
AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue
SM Steculorum, J Ruud, I Karakasilioti, H Backes, LE Ruud, K Timper, ...
Cell 165 (1), 125-138, 2016
2492016
IL-6 regulates M2 polarization and local proliferation of adipose tissue macrophages in obesity
J Braune, U Weyer, C Hobusch, J Mauer, JC Brüning, I Bechmann, ...
The Journal of Immunology 198 (7), 2927-2934, 2017
2412017
Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity
A Jais, M Solas, H Backes, B Chaurasia, A Kleinridders, S Theurich, ...
Cell 165 (4), 882-895, 2016
2302016
FTO controls reversible m6Am RNA methylation during snRNA biogenesis
J Mauer, M Sindelar, V Despic, T Guez, BR Hawley, JJ Vasseur, ...
Nature chemical biology 15 (4), 340-347, 2019
2202019
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
BF Belgardt, J Mauer, FT Wunderlich, MB Ernst, M Pal, G Spohn, ...
Proceedings of the National Academy of Sciences 107 (13), 6028-6033, 2010
1912010
Single copy shRNA configuration for ubiquitous gene knockdown in mice
J Seibler, B Küter-Luks, H Kern, S Streu, L Plum, J Mauer, R Kühn, ...
Nucleic acids research 33 (7), e67-e67, 2005
1372005
Hierarchical prediction errors in midbrain and septum during social learning
AO Diaconescu, C Mathys, LAE Weber, L Kasper, J Mauer, KE Stephan
Social cognitive and affective neuroscience 12 (4), 618-634, 2017
1312017
Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss
J Schmitz, N Evers, M Awazawa, HT Nicholls, HS Brönneke, A Dietrich, ...
Molecular metabolism 5 (5), 328-339, 2016
1242016
Hepatic Bax inhibitor-1 inhibits IRE1α and protects from obesity-associated insulin resistance and glucose intolerance
B Bailly-Maitre, BF Belgardt, SD Jordan, B Coornaert, MJ von Freyend, ...
Journal of biological chemistry 285 (9), 6198-6207, 2010
1242010
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits
S Hult, R Soylu, T Björklund, BF Belgardt, J Mauer, JC Brüning, D Kirik, ...
Cell metabolism 13 (4), 428-439, 2011
1202011
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
CM Wunderlich, PJ Ackermann, AL Ostermann, P Adams-Quack, MC Vogt, ...
Nature communications 9 (1), 1-16, 2018
1182018
FTO, m6Am, and the hypothesis of reversible epitranscriptomic mRNA modifications
J Mauer, SR Jaffrey
FEBS letters 592 (12), 2012-2022, 2018
1162018
Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance
J Mauer, B Chaurasia, L Plum, T Quast, B Hampel, M Blüher, W Kolanus, ...
PLoS genetics 6 (5), e1000938, 2010
1162010
IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis
S Theurich, E Tsaousidou, R Hanssen, AM Lempradl, J Mauer, K Timper, ...
Cell metabolism 26 (1), 171-184. e6, 2017
1152017
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