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Tillmann Heinisch
Tillmann Heinisch
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Artificial metalloenzymes: reaction scope and optimization strategies
F Schwizer, Y Okamoto, T Heinisch, Y Gu, MM Pellizzoni, V Lebrun, ...
Chemical reviews 118 (1), 142-231, 2018
6692018
Directed evolution of artificial metalloenzymes for in vivo metathesis
M Jeschek, R Reuter, T Heinisch, C Trindler, J Klehr, S Panke, TR Ward
Nature 537 (7622), 661-665, 2016
4312016
Artificial metalloenzymes based on the biotin–streptavidin technology: challenges and opportunities
T Heinisch, TR Ward
Accounts of chemical research 49 (9), 1711-1721, 2016
1862016
Artificial transfer hydrogenases for the enantioselective reduction of cyclic imines
M Dürrenberger, T Heinisch, YM Wilson, T Rossel, E Nogueira, L Knörr, ...
Angewandte Chemie International Edition 13 (50), 3026-3029, 2011
1852011
Design strategies for the creation of artificial metalloenzymes
T Heinisch, TR Ward
Current opinion in chemical biology 14 (2), 184-199, 2010
1502010
A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
Y Okamoto, R Kojima, F Schwizer, E Bartolami, T Heinisch, S Matile, ...
Nature communications 9 (1), 1943, 2018
1192018
A dual anchoring strategy for the localization and activation of artificial metalloenzymes based on the biotin–streptavidin technology
JM Zimbron, T Heinisch, M Schmid, D Hamels, ES Nogueira, T Schirmer, ...
Journal of the American Chemical Society 135 (14), 5384-5388, 2013
1172013
Improving the catalytic performance of an artificial metalloenzyme by computational design
T Heinisch, M Pellizzoni, M Dürrenberger, CE Tinberg, V Köhler, ...
Journal of the American Chemical Society 137 (32), 10414-10419, 2015
1012015
E. coli surface display of streptavidin for directed evolution of an allylic deallylase
T Heinisch, F Schwizer, B Garabedian, E Csibra, M Jeschek, ...
Chemical science 9 (24), 5383-5388, 2018
922018
Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines
FW Monnard, ES Nogueira, T Heinisch, T Schirmer, TR Ward
Chemical Science 4 (8), 3269-3274, 2013
892013
OsO4⋅ Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis‐Dihydroxylation of Olefins
V Köhler, J Mao, T Heinisch, A Pordea, A Sardo, YM Wilson, L Knörr, ...
Angewandte Chemie-International Edition 50 (46), 10863, 2011
892011
Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor
FW Monnard, T Heinisch, ES Nogueira, T Schirmer, TR Ward
Chemical communications 47 (29), 8238-8240, 2011
892011
Structural, kinetic, and docking studies of artificial imine reductases based on biotin–streptavidin technology: an induced lock-and-key hypothesis
VM Robles, M Dürrenberger, T Heinisch, A Lledos, T Schirmer, TR Ward, ...
Journal of the American Chemical Society 136 (44), 15676-15683, 2014
832014
Peroxide activation regulated by hydrogen bonds within artificial Cu proteins
SI Mann, T Heinisch, TR Ward, AS Borovik
Journal of the American Chemical Society 139 (48), 17289-17292, 2017
552017
Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE
SC Dodani, JKB Cahn, T Heinisch, S Brinkmann‐Chen, JA McIntosh, ...
ChemBioChem 15 (15), 2259-2267, 2014
552014
Radical biocatalysis: Using non-natural single electron transfer mechanisms to access new enzymatic functions
TK Hyster
Synlett 31 (03), 248-254, 2020
422020
Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase within a Biocompatible Compartment.
T Heinisch, K Langowska, P Tanner, JL Reymond, W Meier, C Palivan, ...
ChemCatChem 5 (3), 2013
422013
Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase
M Hestericová, T Heinisch, M Lenz, TR Ward
Dalton Transactions 47 (32), 10837-10841, 2018
332018
Modular artificial cupredoxins
SI Mann, T Heinisch, AC Weitz, MP Hendrich, TR Ward, AS Borovik
Journal of the American Chemical Society 138 (29), 9073-9076, 2016
282016
Latest developments in metalloenzyme design and repurposing
T Heinisch, TR Ward
European Journal of Inorganic Chemistry 2015 (21), 3406-3418, 2015
232015
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