| Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, ... The Journal of clinical investigation 110 (6), 851-860, 2002 | 1679 | 2002 |
| Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function K Maedler, GA Spinas, D Dyntar, W Moritz, N Kaiser, MY Donath Diabetes 50 (1), 69-76, 2001 | 772 | 2001 |
| Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function K Maedler, J Oberholzer, P Bucher, GA Spinas, MY Donath Diabetes 52 (3), 726-733, 2003 | 739 | 2003 |
| Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes MY Donath, J Størling, K Maedler, T Mandrup-Poulsen Journal of molecular medicine 81, 455-470, 2003 | 643 | 2003 |
| Mechanisms of β-cell death in type 2 diabetes MY Donath, JA Ehses, K Maedler, DM Schumann, H Ellingsgaard, ... Diabetes 54 (suppl_2), S108-S113, 2005 | 616 | 2005 |
| Glucose induces β-cell apoptosis via upregulation of the Fas receptor in human islets K Maedler, GA Spinas, R Lehmann, P Sergeev, M Weber, A Fontana, ... diabetes 50 (8), 1683-1690, 2001 | 546 | 2001 |
| Sulfonylurea induced β-cell apoptosis in cultured human islets K Maedler, RD Carr, D Bosco, RA Zuellig, T Berney, MY Donath The Journal of Clinical Endocrinology & Metabolism 90 (1), 501-506, 2005 | 478 | 2005 |
| Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets L Shu, NS Sauter, FT Schulthess, AV Matveyenko, J Oberholzer, ... Diabetes 57 (3), 645-653, 2008 | 398 | 2008 |
| Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function L Shu, AV Matveyenko, J Kerr-Conte, JH Cho, CHS McIntosh, K Maedler Human molecular genetics 18 (13), 2388-2399, 2009 | 364 | 2009 |
| Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets K Maedler, P Sergeev, JA Ehses, Z Mathe, D Bosco, T Berney, JM Dayer, ... Proceedings of the National Academy of Sciences 101 (21), 8138-8143, 2004 | 358 | 2004 |
| Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes D Dyntar, M Eppenberger-Eberhardt, K Maedler, M Pruschy, ... Diabetes 50 (9), 2105-2113, 2001 | 275 | 2001 |
| The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia NS Sauter, FT Schulthess, R Galasso, LW Castellani, K Maedler Endocrinology 149 (5), 2208-2218, 2008 | 264 | 2008 |
| CXCL10 impairs β cell function and viability in diabetes through TLR4 signaling FT Schulthess, F Paroni, NS Sauter, L Shu, P Ribaux, L Haataja, ... Cell metabolism 9 (2), 125-139, 2009 | 242 | 2009 |
| Aging correlates with decreased β-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 K Maedler, DM Schumann, F Schulthess, J Oberholzer, D Bosco, ... Diabetes 55 (9), 2455-2462, 2006 | 230 | 2006 |
| Extracellular matrix protects pancreatic β-cells against apoptosis: role of short-and long-term signaling pathways E Hammar, G Parnaud, D Bosco, N Perriraz, K Maedler, M Donath, ... Diabetes 53 (8), 2034-2041, 2004 | 221 | 2004 |
| MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes A Ardestani, F Paroni, Z Azizi, S Kaur, V Khobragade, T Yuan, T Frogne, ... Nature medicine 20 (4), 385-397, 2014 | 216 | 2014 |
| Low concentration of interleukin-1β induces FLICE-inhibitory protein–mediated β-cell proliferation in human pancreatic islets K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D Bosco, ... Diabetes 55 (10), 2713-2722, 2006 | 210 | 2006 |
| FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication K Maedler, A Fontana, F Ris, P Sergeev, C Toso, J Oberholzer, ... Proceedings of the National Academy of Sciences 99 (12), 8236-8241, 2002 | 198 | 2002 |
| Glucose-and interleukin-1β-induced β-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea … K Maedler, J Størling, J Sturis, RA Zuellig, GA Spinas, POG Arkhammar, ... Diabetes 53 (7), 1706-1713, 2004 | 196 | 2004 |
| Interleukin-1 beta targeted therapy for type 2 diabetes K Maedler, G Dharmadhikari, DM Schumann, J Størling Expert opinion on biological therapy 9 (9), 1177-1188, 2009 | 174 | 2009 |
