Kathrin Maedler
Kathrin Maedler
Islet Biology Laboratory, University of Bremen
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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
K Maedler, P Sergeev, F Ris, J Oberholzer, HI Joller-Jemelka, GA Spinas, ...
The Journal of clinical investigation 110 (6), 851-860, 2002
Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
K Maedler, GA Spinas, D Dyntar, W Moritz, N Kaiser, MY Donath
Diabetes 50 (1), 69-76, 2001
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
K Maedler, J Oberholzer, P Bucher, GA Spinas, MY Donath
Diabetes 52 (3), 726-733, 2003
Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes
MY Donath, J Størling, K Maedler, T Mandrup-Poulsen
Journal of molecular medicine 81, 455-470, 2003
Mechanisms of β-cell death in type 2 diabetes
MY Donath, JA Ehses, K Maedler, DM Schumann, H Ellingsgaard, ...
Diabetes 54 (suppl_2), S108-S113, 2005
Glucose induces β-cell apoptosis via upregulation of the Fas receptor in human islets
K Maedler, GA Spinas, R Lehmann, P Sergeev, M Weber, A Fontana, ...
diabetes 50 (8), 1683-1690, 2001
Sulfonylurea induced β-cell apoptosis in cultured human islets
K Maedler, RD Carr, D Bosco, RA Zuellig, T Berney, MY Donath
The Journal of Clinical Endocrinology & Metabolism 90 (1), 501-506, 2005
Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets
L Shu, NS Sauter, FT Schulthess, AV Matveyenko, J Oberholzer, ...
Diabetes 57 (3), 645-653, 2008
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired beta-cell function
L Shu, AV Matveyenko, J Kerr-Conte, JH Cho, CHS McIntosh, K Maedler
Human molecular genetics 18 (13), 2388-2399, 2009
Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets
K Maedler, P Sergeev, JA Ehses, Z Mathe, D Bosco, T Berney, JM Dayer, ...
Proceedings of the National Academy of Sciences 101 (21), 8138-8143, 2004
Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes
D Dyntar, M Eppenberger-Eberhardt, K Maedler, M Pruschy, ...
Diabetes 50 (9), 2105-2113, 2001
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
NS Sauter, FT Schulthess, R Galasso, LW Castellani, K Maedler
Endocrinology 149 (5), 2208-2218, 2008
CXCL10 impairs β cell function and viability in diabetes through TLR4 signaling
FT Schulthess, F Paroni, NS Sauter, L Shu, P Ribaux, L Haataja, ...
Cell metabolism 9 (2), 125-139, 2009
Aging correlates with decreased β-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
K Maedler, DM Schumann, F Schulthess, J Oberholzer, D Bosco, ...
Diabetes 55 (9), 2455-2462, 2006
Extracellular matrix protects pancreatic β-cells against apoptosis: role of short-and long-term signaling pathways
E Hammar, G Parnaud, D Bosco, N Perriraz, K Maedler, M Donath, ...
Diabetes 53 (8), 2034-2041, 2004
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
A Ardestani, F Paroni, Z Azizi, S Kaur, V Khobragade, T Yuan, T Frogne, ...
Nature medicine 20 (4), 385-397, 2014
Low concentration of interleukin-1β induces FLICE-inhibitory protein–mediated β-cell proliferation in human pancreatic islets
K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D Bosco, ...
Diabetes 55 (10), 2713-2722, 2006
FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
K Maedler, A Fontana, F Ris, P Sergeev, C Toso, J Oberholzer, ...
Proceedings of the National Academy of Sciences 99 (12), 8236-8241, 2002
Glucose-and interleukin-1β-induced β-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea …
K Maedler, J Størling, J Sturis, RA Zuellig, GA Spinas, POG Arkhammar, ...
Diabetes 53 (7), 1706-1713, 2004
Interleukin-1 beta targeted therapy for type 2 diabetes
K Maedler, G Dharmadhikari, DM Schumann, J Størling
Expert opinion on biological therapy 9 (9), 1177-1188, 2009
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