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Hao Wu
Hao Wu
Asa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical School
Verified email at crystal.harvard.edu - Homepage
Title
Cited by
Cited by
Year
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
X Liu, Z Zhang, J Ruan, Y Pan, VG Magupalli, H Wu, J Lieberman
Nature 535 (7610), 153-158, 2016
25682016
ABAD directly links Aß to mitochondrial toxicity in Alzheimer's disease
JW Lustbader, M Cirilli, C Lin, HW Xu, K Takuma, N Wang, C Caspersen, ...
Science 304 (5669), 448-452, 2004
15932004
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
H Wu, E Esteve, V Tremaroli, MT Khan, R Caesar, L Mannerås-Holm, ...
Nature medicine 23 (7), 850-858, 2017
14222017
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ...
Cell 156 (6), 1193-1206, 2014
12502014
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
SC Lin, YC Lo, H Wu
Nature 465 (7300), 885-890, 2010
12322010
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
J Li, T McQuade, AB Siemer, J Napetschnig, K Moriwaki, YS Hsiao, ...
Cell 150 (2), 339-350, 2012
12172012
Molecular basis of NF-κB signaling
J Napetschnig, H Wu
Annual review of biophysics 42, 443-468, 2013
10932013
Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Z Zhang, Y Zhang, S Xia, Q Kong, S Li, X Liu, C Junqueira, KF Meza-Sosa, ...
Nature 579 (7799), 415-420, 2020
10302020
The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages
CL Evavold, J Ruan, Y Tan, S Xia, H Wu, JC Kagan
Immunity 48 (1), 35-44. e6, 2018
9782018
Distinct molecular mechanism for initiating TRAF6 signalling
H Ye, JR Arron, B Lamothe, M Cirilli, T Kobayashi, NK Shevde, D Segal, ...
Nature 418 (6896), 443-447, 2002
8012002
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ...
Science 362 (6418), 1064-1069, 2018
7502018
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
Y Huang, YC Park, RL Rich, D Segal, DG Myszka, H Wu
Cell 104 (5), 781-790, 2001
7472001
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction
JY Chung, YC Park, H Ye, H Wu
Journal of cell science 115 (4), 679-688, 2002
7422002
The three-dimensional structure of canine parvovirus and its functional implications
J Tsao, MS Chapman, M Agbandje, W Keller, K Smith, H Wu, M Luo, ...
Science 251 (5000), 1456-1464, 1991
6701991
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao, J Ruan, X Luo, X Lou, ...
Nature immunology 21 (7), 736-745, 2020
6592020
Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein
H Wu, JW Lustbader, Y Liu, RE Canfield, WA Hendrickson
Structure 2 (6), 545-558, 1994
6071994
The death domain superfamily in intracellular signaling of apoptosis and inflammation
HH Park, YC Lo, SC Lin, L Wang, JK Yang, H Wu
Annu. Rev. Immunol. 25, 561-586, 2007
6052007
Microbially produced imidazole propionate impairs insulin signaling through mTORC1
A Koh, A Molinaro, M Ståhlman, MT Khan, C Schmidt, L Mannerås-Holm, ...
Cell 175 (4), 947-961. e17, 2018
5852018
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
H Sharif, L Wang, WL Wang, VG Magupalli, L Andreeva, Q Qiao, ...
Nature 570 (7761), 338-343, 2019
5572019
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
I Zanoni, Y Tan, M Di Gioia, A Broggi, J Ruan, J Shi, CA Donado, F Shao, ...
Science 352 (6290), 1232-1236, 2016
5042016
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