The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease M Moutinho, SS Puntambekar, AP Tsai, I Coronel, PB Lin, BT Casali, ... Science translational medicine 14 (637), eabl7634, 2022 | 46 | 2022 |
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons C Arredondo, C Cefaliello, A Dyrda, N Jury, P Martinez, I Díaz, A Amaro, ... Neuron 110 (10), 1656-1670. e12, 2022 | 42 | 2022 |
Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann–Pick disease type B M Acuña, P Martínez, C Moraga, X He, M Moraga, B Hunter, P Nuernberg, ... European Journal of Human Genetics 24 (2), 208-213, 2016 | 39 | 2016 |
NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB‐P, and H3K27ac FJ Bustos, N Jury, P Martinez, E Ampuero, M Campos, S Abarzúa, ... Journal of cellular physiology 232 (12), 3677-3692, 2017 | 37 | 2017 |
Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease MC Vázquez, P Martínez, AR Alvarez, M González, S Zanlungo Biometals 25, 777-786, 2012 | 27 | 2012 |
Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy H Patel, P Martinez, A Perkins, X Taylor, N Jury, D McKinzie, ... Neurobiology of aging 109, 52-63, 2022 | 26 | 2022 |
Activated endothelial cells induce a distinct type of astrocytic reactivity X Taylor, P Cisternas, N Jury, P Martinez, X Huang, Y You, ... Communications biology 5 (1), 282, 2022 | 24 | 2022 |
Bassoon contributes to tau-seed propagation and neurotoxicity P Martinez, H Patel, Y You, N Jury, A Perkins, A Lee-Gosselin, X Taylor, ... Nature neuroscience 25 (12), 1597-1607, 2022 | 23 | 2022 |
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice N Jury, S Abarzua, I Diaz, MV Guerra, E Ampuero, P Cubillos, P Martinez, ... Clinical Epigenetics 12, 1-15, 2020 | 23 | 2020 |
Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala S Linsambarth, F Carvajal, R Moraga, L Mendez, G Tamburini, I Jimenez, ... | 17 | 2021 |
Hepatic metabolic response to restricted copper intake in a Niemann–Pick C murine model G Argüello, P Martinez, J Pena, O Chen, F Platt, S Zanlungo, M González Metallomics 6 (8), 1527-1539, 2014 | 10 | 2014 |
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation M Moutinho, I Coronel, AP Tsai, GV Di Prisco, T Pennington, BK Atwood, ... Genome Medicine 15 (1), 11, 2023 | 9 | 2023 |
The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity P Cisternas, X Taylor, P Martinez, O Maldonado, N Jury, ... Brain Communications 4 (5), fcac235, 2022 | 4 | 2022 |
The role of microglia niacin receptor (HCAR2) in Alzheimer's disease M Moutinho, APY Tsai, SS Puntambekar, BT Casali, PBC Lin, J Patel, ... Alzheimer's & Dementia 17, e052716, 2021 | 2 | 2021 |
Network analysis identifies strain-dependent response to tau and tau seeding-associated genes DJ Acri, Y You, MD Tate, H Karahan, P Martinez, B McCord, AD Sharify, ... Journal of Experimental Medicine 220 (11), e20230180, 2023 | 1 | 2023 |
Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer’s disease N Jury-Garfe, Y You, P Martínez, J Redding-Ochoa, H Karahan, ... bioRxiv, 2023 | 1 | 2023 |
Mutation in presynaptic protein Bassoon induces tauopathy in vivo H Patel, P Martinez, Y You, N Kouri, DM Rothberg, H Yaguchi, S Tanaka, ... Alzheimer's & Dementia 19, e078813, 2023 | | 2023 |
Glia response on Amyloid plaque microenvironment protects against pathological tau conversion in Alzheimer’s disease resilience NJ Garfe, Y You, J Redding, P Martinez, H Karahan, J Kim, JC Troncoso, ... Alzheimer's & Dementia 19, e079845, 2023 | | 2023 |
The role of Tau‐seed interactome in Alzheimer’s disease and other tauopathies P Martinez, H Patel, Y You, NJ Garfe, J Zhang, JC Troncoso, CAL Reeves Alzheimer's & Dementia 19, e074889, 2023 | | 2023 |
Uncovering new tau aggregation and spreading mechanism through AD tau‐seed interactome analysis P Martinez, Y You, H Patel, NJ Garfe, J Redding, JC Troncoso, ... Alzheimer's & Dementia 19, e077875, 2023 | | 2023 |