David Solit
David Solit
Director, Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org - Homepage
Title
Cited by
Cited by
Year
Comprehensive molecular characterization of human colon and rectal cancer
Cancer Genome Atlas Network
Nature 487 (7407), 330, 2012
50322012
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly, F Rojo, QB She, D Solit, GB Mills, D Smith, H Lane, ...
Cancer research 66 (3), 1500-1508, 2006
26382006
Comprehensive molecular characterization of urothelial bladder carcinoma
Cancer Genome Atlas Research Network
Nature 507 (7492), 315, 2014
18022014
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
R Straussman, T Morikawa, K Shee, M Barzily-Rokni, ZR Qian, J Du, ...
Nature 487 (7408), 500-504, 2012
15652012
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
S Misale, R Yaeger, S Hobor, E Scala, M Janakiraman, D Liska, E Valtorta, ...
Nature 486 (7404), 532-536, 2012
15592012
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
A Zehir, R Benayed, RH Shah, A Syed, S Middha, HR Kim, P Srinivasan, ...
Nature medicine 23 (6), 703, 2017
15392017
BRAF mutation predicts sensitivity to MEK inhibition
DB Solit, LA Garraway, CA Pratilas, A Sawai, G Getz, A Basso, Q Ye, ...
Nature 439 (7074), 358-362, 2006
14062006
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)
PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ...
Nature 480 (7377), 387-390, 2011
13542011
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
RM Samstein, CH Lee, AN Shoushtari, MD Hellmann, R Shen, ...
Nature genetics 51 (2), 202-206, 2019
9942019
Inherited DNA-repair gene mutations in men with metastatic prostate cancer
CC Pritchard, J Mateo, MF Walsh, N De Sarkar, W Abida, H Beltran, ...
N Engl J Med 375, 443-453, 2016
8482016
OncoKB: a precision oncology knowledge base
D Chakravarty, J Gao, S Phillips, R Kundra, H Zhang, J Wang, ...
JCO precision oncology 1, 1-16, 2017
7412017
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen
Journal of Biological Chemistry 277 (42), 39858-39866, 2002
6932002
Genome sequencing identifies a basis for everolimus sensitivity
G Iyer, AJ Hanrahan, MI Milowsky, H Al-Ahmadie, SN Scott, ...
Science 338 (6104), 221-221, 2012
6422012
Molecular determinants of response to anti–programmed cell death (PD)-1 and anti–programmed death-ligand 1 (PD-L1) blockade in patients with non–small-cell lung cancer profiled …
H Rizvi, F Sanchez-Vega, K La, W Chatila, P Jonsson, D Halpenny, ...
Journal of Clinical Oncology 36 (7), 633, 2018
6342018
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
JC Ricarte-Filho, M Ryder, DA Chitale, M Rivera, A Heguy, M Ladanyi, ...
Cancer research 69 (11), 4885-4893, 2009
5392009
V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway
CA Pratilas, BS Taylor, Q Ye, A Viale, C Sander, DB Solit, N Rosen
Proceedings of the National Academy of Sciences 106 (11), 4519-4524, 2009
5182009
Tumor adaptation and resistance to RAF inhibitors
P Lito, N Rosen, DB Solit
Nature medicine 19 (11), 1401-1409, 2013
5152013
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
DB Solit, FF Zheng, M Drobnjak, PN Münster, B Higgins, D Verbel, ...
Clinical cancer research 8 (5), 986-993, 2002
5102002
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
D Chowell, LGT Morris, CM Grigg, JK Weber, RM Samstein, V Makarov, ...
Science 359 (6375), 582-587, 2018
4722018
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
MT Chang, S Asthana, SP Gao, BH Lee, JS Chapman, C Kandoth, JJ Gao, ...
Nature biotechnology 34 (2), 155-163, 2016
4632016
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