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Stephen Thorpe
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The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation
SD Thorpe, CT Buckley, T Vinardell, FJ O’Brien, VA Campbell, DJ Kelly
Annals of biomedical engineering 38 (9), 2896-2909, 2010
2442010
Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells
SJ Heo, SD Thorpe, TP Driscoll, RL Duncan, DA Lee, RL Mauck
Scientific reports 5 (1), 16895, 2015
1792015
Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity
SJ Heo, TP Driscoll, SD Thorpe, NL Nerurkar, BM Baker, MT Yang, ...
Elife 5, e18207, 2016
1612016
The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels
CT Buckley, SD Thorpe, FJ O’Brien, AJ Robinson, DJ Kelly
Journal of the mechanical behavior of biomedical materials 2 (5), 512-521, 2009
1612009
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells
SD Thorpe, CT Buckley, T Vinardell, FJ O’Brien, VA Campbell, DJ Kelly
Biochemical and biophysical research communications 377 (2), 458-462, 2008
1432008
Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells
G Pattappa, SD Thorpe, NC Jegard, HK Heywood, JD de Bruijn, DA Lee
Tissue Engineering Part C: Methods 19 (1), 68-79, 2013
1382013
Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells
CT Buckley, T Vinardell, SD Thorpe, MG Haugh, E Jones, D McGonagle, ...
Journal of biomechanics 43 (5), 920-926, 2010
1292010
Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression
EG Meyer, CT Buckley, SD Thorpe, DJ Kelly
Journal of biomechanics 43 (13), 2516-2523, 2010
1192010
Cell–matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
AJ Steward, SD Thorpe, T Vinardell, CT Buckley, DR Wagner, DJ Kelly
Acta Biomaterialia 8 (6), 2153-2159, 2012
982012
Chondrogenesis and Integration of Mesenchymal Stem Cells Within an In Vitro Cartilage Defect Repair Model
T Vinardell, SD Thorpe, CT Buckley, DJ Kelly
Annals of biomedical engineering 37, 2556-2565, 2009
962009
Modulating gradients in regulatory signals within mesenchymal stem cell seeded hydrogels: a novel strategy to engineer zonal articular cartilage
SD Thorpe, T Nagel, SF Carroll, DJ Kelly
PLoS One 8 (4), e60764, 2013
812013
Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood, MM Knight, SD Thorpe
Frontiers in bioengineering and biotechnology 8, 602646, 2020
752020
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival
E Cortes, D Lachowski, B Robinson, M Sarper, JS Teppo, SD Thorpe, ...
EMBO reports 20 (1), e46557, 2019
742019
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
A Chronopoulos, SD Thorpe, E Cortes, D Lachowski, AJ Rice, ...
Nature materials 19 (6), 669-678, 2020
732020
Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression
MG Haugh, EG Meyer, SD Thorpe, T Vinardell, GP Duffy, DJ Kelly
Tissue Engineering Part A 17 (23-24), 3085-3093, 2011
732011
Adipogenic differentiation of hMSCs is mediated by recruitment of IGF‐1r onto the primary cilium associated with cilia elongation
MT Dalbay, SD Thorpe, JT Connelly, JP Chapple, MM Knight
Stem Cells 33 (6), 1952-1961, 2015
692015
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
E Cortes, M Sarper, B Robinson, D Lachowski, A Chronopoulos, ...
EMBO reports 20 (1), e46556, 2019
662019
Retinoic acid receptor‐β is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells
E Cortes, D Lachowski, A Rice, A Chronopoulos, B Robinson, S Thorpe, ...
Hepatology 69 (2), 785-802, 2019
63*2019
Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity
SD Thorpe, DA Lee
Nucleus 8 (3), 287-300, 2017
572017
European Society of Biomechanics SM Perren Award 2012: the external mechanical environment can override the influence of local substrate in determining stem cell fate
SD Thorpe, CT Buckley, AJ Steward, DJ Kelly
Journal of Biomechanics 45 (15), 2483-2492, 2012
572012
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