| Visualizing the mechanical activation of Src Y Wang, EL Botvinick, Y Zhao, MW Berns, S Usami, RY Tsien, S Chien Nature 434 (7036), 1040-1045, 2005 | 789 | 2005 |
| Rapid signal transduction in living cells is a unique feature of mechanotransduction S Na, O Collin, F Chowdhury, B Tay, M Ouyang, Y Wang, N Wang Proceedings of the National Academy of Sciences 105 (18), 6626-6631, 2008 | 490 | 2008 |
| Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing Y Wang, JYJ Shyy, S Chien Annu. Rev. Biomed. Eng. 10, 1-38, 2008 | 366 | 2008 |
| The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells S Li, P Butler, Y Wang, Y Hu, DC Han, S Usami, JL Guan, S Chien Proceedings of the National Academy of Sciences 99 (6), 3546-3551, 2002 | 319 | 2002 |
| Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis C Vennin, VT Chin, SC Warren, MC Lucas, D Herrmann, A Magenau, ... Science translational medicine 9 (384), eaai8504, 2017 | 222 | 2017 |
| Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors M Ouyang, J Sun, S Chien, Y Wang Proceedings of the National Academy of Sciences 105 (38), 14353-14358, 2008 | 200 | 2008 |
| Photocaged DNAzymes as a general method for sensing metal ions in living cells K Hwang, P Wu, T Kim, L Lei, S Tian, Y Wang, Y Lu Angewandte Chemie International Edition 53 (50), 13798-13802, 2014 | 183 | 2014 |
| FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells YL Hu, S Lu, KW Szeto, J Sun, Y Wang, JC Lasheras, S Chien Scientific reports 4 (1), 6024, 2014 | 182 | 2014 |
| Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations H Miao, YL Hu, YT Shiu, S Yuan, Y Zhao, R Kaunas, Y Wang, G Jin, ... Journal of vascular research 42 (1), 77-89, 2005 | 182 | 2005 |
| Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins J Seong, A Tajik, J Sun, JL Guan, MJ Humphries, SE Craig, A Shekaran, ... Proceedings of the National Academy of Sciences 110 (48), 19372-19377, 2013 | 177 | 2013 |
| Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression Y Tan, A Tajik, J Chen, Q Jia, F Chowdhury, L Wang, J Chen, S Zhang, ... Nature communications 5 (1), 4619, 2014 | 174 | 2014 |
| Interplay between integrins and FLK-1 in shear stress-induced signaling Y Wang, H Miao, S Li, KD Chen, YS Li, S Yuan, JYJ Shyy, S Chien American Journal of Physiology-Cell Physiology 283 (5), C1540-C1547, 2002 | 172 | 2002 |
| Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells TJ Kim, J Seong, M Ouyang, J Sun, S Lu, JP Hong, N Wang, Y Wang Journal of cellular physiology 218 (2), 285-293, 2009 | 164 | 2009 |
| Mechanogenetics for the remote and noninvasive control of cancer immunotherapy Y Pan, S Yoon, J Sun, Z Huang, C Lee, M Allen, Y Wu, YJ Chang, ... Proceedings of the National Academy of Sciences 115 (5), 992-997, 2018 | 162 | 2018 |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan C Vennin, P Mélénec, R Rouet, M Nobis, AS Cazet, KJ Murphy, ... Nature communications 10 (1), 3637, 2019 | 161 | 2019 |
| Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states TJ Kim, S Zheng, J Sun, I Muhamed, J Wu, L Lei, X Kong, DE Leckband, ... Current biology 25 (2), 218-224, 2015 | 160 | 2015 |
| The primary cilium functions as a mechanical and calcium signaling nexus KL Lee, MD Guevarra, AM Nguyen, MC Chua, Y Wang, CR Jacobs Cilia 4 (1), 1-13, 2015 | 136 | 2015 |
| Simultaneous Visualization of Protumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy TransferVisualizing Src and MT1-MMP Activities in a Single Cell M Ouyang, H Huang, NC Shaner, AG Remacle, SA Shiryaev, AY Strongin, ... Cancer research 70 (6), 2204-2212, 2010 | 132 | 2010 |
| Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras Y Wang, G Jin, H Miao, JYS Li, S Usami, S Chien Proceedings of the National Academy of Sciences 103 (6), 1774-1779, 2006 | 131 | 2006 |
| Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer J Seong, M Ouyang, T Kim, J Sun, PC Wen, S Lu, Y Zhuo, NM Llewellyn, ... Nature communications 2 (1), 406, 2011 | 129 | 2011 |
Shu ChienProfessor of Bioengineering, University of California, San DiegoBestätigte E-Mail-Adresse bei eng.ucsd.edu
