Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ... Cell metabolism 7 (1), 45-56, 2008 | 2133 | 2008 |
The failing heart relies on ketone bodies as a fuel G Aubert, OJ Martin, JL Horton, L Lai, RB Vega, TC Leone, T Koves, ... Circulation 133 (8), 698-705, 2016 | 636 | 2016 |
Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced … TR Koves, P Li, J An, T Akimoto, D Slentz, O Ilkayeva, GL Dohm, Z Yan, ... Journal of Biological Chemistry 280 (39), 33588-33598, 2005 | 567 | 2005 |
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance J An, DM Muoio, M Shiota, Y Fujimoto, GW Cline, GI Shulman, TR Koves, ... Nature medicine 10 (3), 268-274, 2004 | 543 | 2004 |
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control RC Noland, TR Koves, SE Seiler, H Lum, RM Lust, O Ilkayeva, ... Journal of biological chemistry 284 (34), 22840-22852, 2009 | 407 | 2009 |
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption JR Ussher, TR Koves, VJJ Cadete, L Zhang, JS Jaswal, SJ Swyrd, ... Diabetes 59 (10), 2453-2464, 2010 | 402 | 2010 |
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase G Laurent, NJ German, AK Saha, VCJ de Boer, M Davies, TR Koves, ... Molecular cell 50 (5), 686-698, 2013 | 392 | 2013 |
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility DM Muoio, RC Noland, JP Kovalik, SE Seiler, MN Davies, KL DeBalsi, ... Cell metabolism 15 (5), 764-777, 2012 | 391 | 2012 |
Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat SE Hemby, C Co, TR Koves, JE Smith, SI Dworkin Psychopharmacology 133, 7-16, 1997 | 349 | 1997 |
Adipose acyl-CoA synthetase-1 directs fatty acids toward β-oxidation and is required for cold thermogenesis JM Ellis, LO Li, PC Wu, TR Koves, O Ilkayeva, RD Stevens, SM Watkins, ... Cell metabolism 12 (1), 53-64, 2010 | 341 | 2010 |
Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach L Lai, TC Leone, MP Keller, OJ Martin, AT Broman, J Nigro, K Kapoor, ... Circulation: Heart Failure 7 (6), 1022-1031, 2014 | 270 | 2014 |
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and β-oxidation and alters phospholipid fatty acid composition LO Li, JM Ellis, HA Paich, S Wang, N Gong, G Altshuller, RJ Thresher, ... Journal of Biological Chemistry 284 (41), 27816-27826, 2009 | 249 | 2009 |
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy JM Ellis, SM Mentock, MA DePetrillo, TR Koves, S Sen, SM Watkins, ... Molecular and cellular biology 31 (6), 1252-1262, 2011 | 204 | 2011 |
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism TR Koves, RC Noland, AL Bates, ST Henes, DM Muoio, RN Cortright American Journal of Physiology-Cell Physiology 288 (5), C1074-C1082, 2005 | 203 | 2005 |
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease DM Muoio, TR Koves Applied Physiology, Nutrition, and Metabolism 32 (5), 874-883, 2007 | 175 | 2007 |
Measurement of fatty acid oxidation rates in animal tissues and cell lines FK Huynh, MF Green, TR Koves, MD Hirschey Methods in enzymology 542, 391-405, 2014 | 164 | 2014 |
Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle A Khodabukus, L Madden, NK Prabhu, TR Koves, CP Jackman, ... Biomaterials 198, 259-269, 2019 | 155 | 2019 |
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet–induced obese mice lacking malonyl CoA decarboxylase JR Ussher, TR Koves, JS Jaswal, L Zhang, O Ilkayeva, JRB Dyck, ... Diabetes 58 (8), 1766-1775, 2009 | 147 | 2009 |
Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness KM Huffman, TR Koves, MJ Hubal, H Abouassi, N Beri, LA Bateman, ... Diabetologia 57, 2282-2295, 2014 | 146 | 2014 |
Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels SL Vrana, KE Vrana, TR Koves, JE Smith, SI Dworkin Journal of neurochemistry 61 (6), 2262-2268, 1993 | 139 | 1993 |