Lawrence Kazak
Lawrence Kazak
Assistant Professor, Goodman Cancer Research Centre and Dept of Biochemistry, McGill University
Verified email at mcgill.ca - Homepage
Title
Cited by
Cited by
Year
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
L Kazak, ET Chouchani, MP Jedrychowski, BK Erickson, K Shinoda, ...
Cell 163 (3), 643-655, 2015
3502015
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
S Kir, JP White, S Kleiner, L Kazak, P Cohen, VE Baracos, ...
Nature 513 (7516), 100-104, 2014
3492014
Minimizing the damage: repair pathways keep mitochondrial DNA intact
L Kazak, A Reyes, IJ Holt
Nature reviews Molecular cell biology 13 (10), 659-671, 2012
3052012
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, ...
Nature 532 (7597), 112-116, 2016
2192016
Fat cells directly sense temperature to activate thermogenesis
L Ye, J Wu, P Cohen, L Kazak, MJ Khandekar, MP Jedrychowski, X Zeng, ...
Proceedings of the National Academy of Sciences 110 (30), 12480-12485, 2013
1972013
IRF4 is a key thermogenic transcriptional partner of PGC-1α
X Kong, A Banks, T Liu, L Kazak, RR Rao, P Cohen, X Wang, S Yu, JC Lo, ...
Cell 158 (1), 69-83, 2014
1712014
Accumulation of succinate controls activation of adipose tissue thermogenesis
EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ...
Nature 560 (7716), 102-106, 2018
1302018
Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling
AM Bertholet, L Kazak, ET Chouchani, MG Bogaczyńska, I Paranjpe, ...
Cell metabolism 25 (4), 811-822. e4, 2017
1122017
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity
L Kazak, ET Chouchani, GZ Lu, MP Jedrychowski, CJ Bare, AI Mina, ...
Cell metabolism 26 (4), 660-671. e3, 2017
1112017
New advances in adaptive thermogenesis: UCP1 and beyond
ET Chouchani, L Kazak, BM Spiegelman
Cell metabolism 29 (1), 27-37, 2019
1002019
Mitochondrial DNA replication proceeds via a ‘bootlace’mechanism involving the incorporation of processed transcripts
A Reyes, L Kazak, SR Wood, T Yasukawa, HT Jacobs, IJ Holt
Nucleic acids research 41 (11), 5837-5850, 2013
982013
IRF3 promotes adipose inflammation and insulin resistance and represses browning
M Kumari, X Wang, L Lantier, A Lyubetskaya, J Eguchi, S Kang, D Tenen, ...
The Journal of clinical investigation 126 (8), 2839-2854, 2016
872016
Actin and myosin contribute to mammalian mitochondrial DNA maintenance
A Reyes, J He, CC Mao, LJ Bailey, M Di Re, H Sembongi, L Kazak, ...
Nucleic acids research 39 (12), 5098-5108, 2011
782011
Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit
J He, HM Cooper, A Reyes, M Di Re, L Kazak, SR Wood, CC Mao, ...
Nucleic acids research 40 (13), 6097-6108, 2012
742012
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction
L Kazak, ET Chouchani, IG Stavrovskaya, GZ Lu, MP Jedrychowski, ...
Proceedings of the National Academy of Sciences 114 (30), 7981-7986, 2017
662017
Alternative translation initiation augments the human mitochondrial proteome
L Kazak, A Reyes, AL Duncan, J Rorbach, SR Wood, G Brea-Calvo, ...
Nucleic acids research 41 (4), 2354-2369, 2013
522013
Effects of endurance training on apoptotic susceptibility in striated muscle
A Vainshtein, L Kazak, DA Hood
Journal of applied physiology 110 (6), 1638-1645, 2011
502011
Brown adipose tissue controls skeletal muscle function via the secretion of myostatin
X Kong, T Yao, P Zhou, L Kazak, D Tenen, A Lyubetskaya, BA Dawes, ...
Cell metabolism 28 (4), 631-643. e3, 2018
452018
Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms
ET Chouchani, L Kazak, BM Spiegelman
Journal of Biological Chemistry 292 (41), 16810-16816, 2017
412017
H+ transport is an integral function of the mitochondrial ADP/ATP carrier
AM Bertholet, ET Chouchani, L Kazak, A Angelin, A Fedorenko, JZ Long, ...
Nature 571 (7766), 515-520, 2019
362019
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