| Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase DM Clarke, TW Loo, G Inesi, DH MacLennan Nature 339 (6224), 476-478, 1989 | 740 | 1989 |
| Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein (∗) TW Loo, DM Clarke Journal of Biological Chemistry 270 (2), 843-848, 1995 | 346 | 1995 |
| Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux TW Loo, DM Clarke The Journal of membrane biology 206, 173-185, 2005 | 301 | 2005 |
| Correction of defective protein kinesis of human P-glycoprotein mutants by substrates and modulators TW Loo, DM Clarke Journal of Biological Chemistry 272 (2), 709-712, 1997 | 284 | 1997 |
| Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein TW Loo, DM Clarke Journal of Biological Chemistry 277 (46), 44332-44338, 2002 | 280 | 2002 |
| Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil TW Loo, DM Clarke Journal of Biological Chemistry 276 (18), 14972-14979, 2001 | 264 | 2001 |
| Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers TW Loo, DM Clarke Journal of Biological Chemistry 276 (40), 36877-36880, 2001 | 260 | 2001 |
| Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein TW Loo, MC Bartlett, DM Clarke Journal of Biological Chemistry 278 (41), 39706-39710, 2003 | 258 | 2003 |
| Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein: direct evidence for the substrate-induced fit mechanism for drug binding TW Loo, MC Bartlett, DM Clarke Journal of Biological Chemistry 278 (16), 13603-13606, 2003 | 247 | 2003 |
| Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides. TW Loo, DM Clarke Journal of Biological Chemistry 269 (10), 7750-7755, 1994 | 237 | 1994 |
| Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase … TW Loo, DM Clarke Journal of Biological Chemistry 270 (37), 21449-21452, 1995 | 236 | 1995 |
| Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity TW Loo, DM Clarke Journal of Biological Chemistry 270 (39), 22957-22961, 1995 | 223 | 1995 |
| The “LSGGQ” motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence TW Loo, MC Bartlett, DM Clarke Journal of Biological Chemistry 277 (44), 41303-41306, 2002 | 212 | 2002 |
| Functional consequences of alterations to polar amino acids located in the transmembrane domain of the Ca2 (+)-ATPase of sarcoplasmic reticulum. DM Clarke, TW Loo, DH MacLennan Journal of Biological Chemistry 265 (11), 6262-6267, 1990 | 198 | 1990 |
| Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein. TW Loo, DM Clarke Journal of Biological Chemistry 268 (27), 19965-19972, 1993 | 195 | 1993 |
| Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate TW Loo, DM Clarke Journal of Biological Chemistry 272 (51), 31945-31948, 1997 | 191 | 1997 |
| Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum DM Clarke, K Maruyama, TW Loo, E Leberer, G Inesi, DH MacLennan Journal of Biological Chemistry 264 (19), 11246-11251, 1989 | 191 | 1989 |
| The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface TW Loo, DM Clarke Journal of Biological Chemistry 274 (35), 24759-24765, 1999 | 189 | 1999 |
| Functional consequences of proline mutations in the cytoplasmic and transmembrane sectors of the Ca2+-ATPase of sarcoplasmic reticulum B Vilsen, JP Andersen, DM Clarke, DH MacLennan Journal of Biological Chemistry 264 (35), 21024-21030, 1989 | 189 | 1989 |
| Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane TW Loo, DM Clarke Journal of Biological Chemistry 275 (50), 39272-39278, 2000 | 186 | 2000 |
