| Molecular dynamics studies on the thermostability of family 11 xylanases M Purmonen, J Valjakka, K Takkinen, T Laitinen, J Rouvinen Protein Engineering, Design & Selection 20 (11), 551-559, 2007 | 147 | 2007 |
| Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase N Aaltonen, JR Savinainen, CR Ribas, J Rönkkö, A Kuusisto, J Korhonen, ... Chemistry & biology 20 (3), 379-390, 2013 | 112 | 2013 |
| Covalent Binding of Three Epoxyalkyl Xylosides to the Active Site of endo-1,4-Xylanase II from Trichoderma reesei, R Havukainen, A Törrönen, T Laitinen, J Rouvinen Biochemistry 35 (29), 9617-9624, 1996 | 108 | 1996 |
| Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization M Ammad-Ud-Din, E Georgii, M Gonen, T Laitinen, O Kallioniemi, ... Journal of chemical information and modeling 54 (8), 2347-2359, 2014 | 102 | 2014 |
| Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling T Pantsar, S Rissanen, D Dauch, T Laitinen, I Vattulainen, A Poso PLoS computational biology 14 (9), e1006458, 2018 | 74 | 2018 |
| Comparative and pharmacophore model for deacetylase SIRT1 T Huhtiniemi, C Wittekindt, T Laitinen, J Leppänen, A Salminen, A Poso, ... Journal of computer-aided molecular design 20, 589-599, 2006 | 67 | 2006 |
| SARS‐CoV‐2–host proteome interactions for antiviral drug discovery X Liu, S Huuskonen, T Laitinen, T Redchuk, M Bogacheva, K Salokas, ... Molecular Systems Biology 17 (11), e10396, 2021 | 61 | 2021 |
| Chiral 1, 3, 4-oxadiazol-2-ones as highly selective FAAH inhibitors JZ Patel, T Parkkari, T Laitinen, AA Kaczor, SM Saario, JR Savinainen, ... Journal of medicinal chemistry 56 (21), 8484-8496, 2013 | 60 | 2013 |
| Identification and optimization of 4‐anilinoquinolines as inhibitors of cyclin G associated kinase CRM Asquith, T Laitinen, JM Bennett, PH Godoi, MP East, GJ Tizzard, ... ChemMedChem 13 (1), 48-66, 2018 | 53 | 2018 |
| Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A) JR Savinainen, JZ Patel, T Parkkari, D Navia-Paldanius, JJT Marjamaa, ... PLoS One 9 (10), e109869, 2014 | 49 | 2014 |
| Loratadine analogues as MAGL inhibitors JZ Patel, S Ahenkorah, M Vaara, M Staszewski, Y Adams, T Laitinen, ... Bioorganic & medicinal chemistry letters 25 (7), 1436-1442, 2015 | 48 | 2015 |
| New in Vitro Tools to Study Human Constitutive Androstane Receptor (CAR) Biology: Discovery and Comparison of Human CAR Inverse Agonists J Küblbeck, J Jyrkkärinne, F Molnár, T Kuningas, J Patel, ... Molecular pharmaceutics 8 (6), 2424-2433, 2011 | 47 | 2011 |
| Use of comprehensive screening methods to detect selective human CAR activators J Küblbeck, T Laitinen, J Jyrkkärinne, T Rousu, A Tolonen, T Abel, ... Biochemical pharmacology 82 (12), 1994-2007, 2011 | 45 | 2011 |
| The effects of sequence variation on genome-wide NRF2 binding—new target genes and regulatory SNPs SM Kuosmanen, S Viitala, T Laitinen, M Peräkylä, P Pölönen, ... Nucleic acids research 44 (4), 1760-1775, 2016 | 42 | 2016 |
| Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL) JR Savinainen, E Kansanen, T Pantsar, D Navia-Paldanius, T Parkkari, ... Molecular pharmacology 86 (5), 522-535, 2014 | 42 | 2014 |
| Peptides and pseudopeptides as SIRT6 deacetylation inhibitors P Kokkonen, M Rahnasto-Rilla, PH Kiviranta, T Huhtiniemi, T Laitinen, ... ACS Medicinal Chemistry Letters 3 (12), 969-974, 2012 | 40 | 2012 |
| Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12) T Parkkari, R Haavikko, T Laitinen, D Navia-Paldanius, R Rytilahti, ... PLoS One 9 (5), e98286, 2014 | 38 | 2014 |
| Optimization of 1, 2, 5‐thiadiazole carbamates as potent and selective ABHD6 inhibitors JZ Patel, TJ Nevalainen, JR Savinainen, Y Adams, T Laitinen, RS Runyon, ... ChemMedChem 10 (2), 253-265, 2015 | 37 | 2015 |
| Identification of novel SIRT3 inhibitor scaffolds by virtual screening HS Salo, T Laitinen, A Poso, E Jarho, M Lahtela-Kakkonen Bioorganic & medicinal chemistry letters 23 (10), 2990-2995, 2013 | 36 | 2013 |
| Free energy simulations and MM–PBSA analyses on the affinity and specificity of steroid binding to antiestradiol antibody T Laitinen, JA Kankare, M Peräkylä PROTEINS: Structure, Function, and Bioinformatics 55 (1), 34-43, 2004 | 35 | 2004 |
Antti PosoProfessor of Drug Design, University of Eastern FinlandVerified email at uef.fi
