Steven G. Van Lanen
Steven G. Van Lanen
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Antitumor antibiotics: bleomycin, enediynes, and mitomycin
U Galm, MH Hager, SG Van Lanen, J Ju, JS Thorson, B Shen
Chemical Reviews 105 (2), 739-758, 2005
Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
BO Bachmann, SG Van Lanen, RH Baltz
Journal of industrial Microbiology and Biotechnology 41 (2), 175-184, 2014
Microbial genomics for the improvement of natural product discovery
SG Van Lanen, B Shen
Current opinion in microbiology 9 (3), 252-260, 2006
Characterization of the Maduropeptin Biosynthetic Gene Cluster from Actinomadura madurae ATCC 39144 Supporting a Unifying Paradigm for Enediyne …
SG Van Lanen, T Oh, W Liu, E Wendt-Pienkowski, B Shen
Journal of the American Chemical Society 129 (43), 13082-13094, 2007
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases
W Liu, K Nonaka, L Nie, J Zhang, SD Christenson, J Bae, SG Van Lanen, ...
Chemistry & biology 12 (3), 293-302, 2005
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold
SG Van Lanen, JS Reader, MA Swairjo, V de Crécy-Lagard, B Lee, ...
Proceedings of the National Academy of Sciences 102 (12), 4264-4269, 2005
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis
J Zhang, SG Van Lanen, J Ju, W Liu, PC Dorrestein, W Li, NL Kelleher, ...
Proceedings of the National Academy of Sciences 105 (5), 1460-1465, 2008
Facile Chemoenzymatic Strategies for the Synthesis and Utilization of S‐Adenosyl‐L‐Methionine Analogues
S Singh, J Zhang, TD Huber, M Sunkara, K Hurley, RD Goff, G Wang, ...
Angewandte Chemie 126 (15), 4046-4050, 2014
Biosynthesis of enediyne antitumor antibiotics
SG Van Lanen, B Shen
Current topics in medicinal chemistry 8 (6), 448-459, 2008
Regiospecific Chlorination of (S)-β-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
S Lin, SG Van Lanen, B Shen
Journal of the American Chemical Society 129 (41), 12432-12438, 2007
The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis
H Jiang, R Zirkle, JG Metz, L Braun, L Richter, SG Van Lanen, B Shen
Journal of the American Chemical Society 130 (20), 6336-6337, 2008
A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis
S Lin, SG Van Lanen, B Shen
Proceedings of the National Academy of Sciences 106 (11), 4183-4188, 2009
The Structure of l-Tyrosine 2,3-Aminomutase from the C-1027 Enediyne Antitumor Antibiotic Biosynthetic Pathway,
CV Christianson, TJ Montavon, SG Van Lanen, B Shen, SD Bruner
Biochemistry 46 (24), 7205-7214, 2007
Enzymatic strategies and biocatalysts for amide bond formation: tricks of the trade outside of the ribosome
A Goswami, SG Van Lanen
Molecular BioSystems 11 (2), 338-353, 2015
Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis
BWK Lee, SG Van Lanen, D Iwata-Reuyl
Biochemistry 46 (44), 12844-12854, 2007
The Biosynthesis of Liposidomycin‐like A‐90289 Antibiotics Featuring a New Type of Sulfotransferase
M Funabashi, S Baba, K Nonaka, M Hosobuchi, Y Fujita, T Shibata, ...
ChemBioChem 11 (2), 184-190, 2010
An ATP-independent strategy for amide bond formation in antibiotic biosynthesis
M Funabashi, Z Yang, K Nonaka, M Hosobuchi, Y Fujita, T Shibata, X Chi, ...
Nature chemical biology 6 (8), 581-586, 2010
Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis
P Pahari, MK Kharel, MD Shepherd, SG van Lanen, J Rohr
Angewandte Chemie 124 (5), 1242-1246, 2012
Biosynthesis of the β-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring β-amino acyl-S-carrier protein intermediates
SG Van Lanen, PC Dorrestein, SD Christenson, W Liu, J Ju, NL Kelleher, ...
Journal of the American Chemical Society 127 (33), 11594-11595, 2005
Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates
Y Zeng, A Kulkarni, Z Yang, PB Patil, W Zhou, X Chi, S Van Lanen, ...
ACS chemical biology 7 (9), 1565-1575, 2012
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