| Comprehensive characterization of cancer driver genes and mutations MH Bailey, C Tokheim, E Porta-Pardo, S Sengupta, D Bertrand, ... Cell 173 (2), 371-385. e18, 2018 | 2142 | 2018 |
| The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation R Hashizume, M Fukuda, I Maeda, H Nishikawa, D Oyake, Y Yabuki, ... Journal of Biological Chemistry 276 (18), 14537-14540, 2001 | 882 | 2001 |
| The histone H3. 3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression KM Chan, D Fang, H Gan, R Hashizume, C Yu, M Schroeder, N Gupta, ... Genes & development 27 (9), 985-990, 2013 | 670 | 2013 |
| Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma R Hashizume, N Andor, Y Ihara, R Lerner, H Gan, X Chen, D Fang, ... Nature medicine 20 (12), 1394-1396, 2014 | 466 | 2014 |
| Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas A Piunti, R Hashizume, MA Morgan, ET Bartom, CM Horbinski, ... Nature medicine 23 (4), 493-500, 2017 | 370 | 2017 |
| DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management F Nassiri, Y Mamatjan, S Suppiah, JH Badhiwala, S Mansouri, S Karimi, ... Neuro-oncology 21 (7), 901-910, 2019 | 197 | 2019 |
| Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer A Grothey, R Hashizume, AA Sahin, PD McCrea British journal of cancer 83 (7), 870-873, 2000 | 195 | 2000 |
| New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163 R Hashizume, T Ozawa, SM Gryaznov, AW Bollen, KR Lamborn, WH Frey, ... Neuro-oncology 10 (2), 112-120, 2008 | 185 | 2008 |
| Targeted Therapy for BRAFV600E Malignant Astrocytoma TP Nicolaides, H Li, DA Solomon, S Hariono, R Hashizume, K Barkovich, ... Clinical Cancer Research 17 (24), 7595-7604, 2011 | 176 | 2011 |
| Expression of Epithelial Cadherin and α–and β–Catenins in Nontumoral Livers and Hepatocellular Carcinomas A Ihara, H Koizumi, R Hashizume, T Uchikoshi Hepatology 23 (6), 1441-1447, 1996 | 175 | 1996 |
| C-erbB-2/HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines A Grothey, R Hashizume, H Ji, BE Tubb, CW Patrick, D Yu, EE Mooney, ... Oncogene 19 (42), 4864-4875, 2000 | 174 | 2000 |
| Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG FJ Cordero, Z Huang, C Grenier, X He, G Hu, RE McLendon, SK Murphy, ... Molecular Cancer Research 15 (9), 1243-1254, 2017 | 156 | 2017 |
| Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy L Wang, Z Zhao, PA Ozark, D Fantini, SA Marshall, EJ Rendleman, ... Nature medicine 24 (6), 758-769, 2018 | 148 | 2018 |
| Targeting Wee1 for the treatment of pediatric high-grade gliomas S Mueller, R Hashizume, X Yang, I Kolkowitz, AK Olow, J Phillips, ... Neuro-oncology 16 (3), 352-360, 2014 | 129 | 2014 |
| Expression of β‐catenin in normal breast tissue and breast carcinoma: a comparative study with epithelial cadherin and α‐catenin R Hashizume, H Koizumi, A Ihara, T Ohta, T Uchikoshi Histopathology 29 (2), 139-146, 1996 | 121 | 1996 |
| Molecular and translational advances in meningiomas S Suppiah, F Nassiri, WL Bi, IF Dunn, CO Hanemann, CM Horbinski, ... Neuro-oncology 21 (Supplement_1), i4-i17, 2019 | 120 | 2019 |
| Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth R Hashizume, A Zhang, S Mueller, MD Prados, RR Lulla, S Goldman, ... Neuro-oncology 18 (11), 1519-1528, 2016 | 118 | 2016 |
| ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis CM Hoeman, FJ Cordero, G Hu, K Misuraca, MM Romero, HJ Cardona, ... Nature communications 10 (1), 1023, 2019 | 100 | 2019 |
| Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics X Huang, AM Dubuc, R Hashizume, J Berg, Y He, J Wang, C Chiang, ... Genes & development 26 (16), 1780-1796, 2012 | 93 | 2012 |
| Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy E Huillard, R Hashizume, JJ Phillips, A Griveau, RA Ihrie, Y Aoki, ... Proceedings of the National Academy of Sciences 109 (22), 8710-8715, 2012 | 93 | 2012 |
