Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome SV Faull, AMC Lau, C Martens, Z Ahdash, K Hansen, H Yebenes, ... Nature communications 10 (1), 3814, 2019 | 49 | 2019 |
The structural basis for Z α1-antitrypsin polymerization in the liver SV Faull, ELK Elliston, B Gooptu, AM Jagger, I Aldobiyan, A Redzej, ... Science advances 6 (43), eabc1370, 2020 | 31 | 2020 |
Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway I Haq, JA Irving, SV Faull, JA Dickens, A Ordóñez, D Belorgey, B Gooptu, ... Bioscience Reports 33 (3), e00046, 2013 | 29 | 2013 |
Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization JA Irving, I Haq, JA Dickens, SV Faull, DA Lomas Biochemical Journal 460 (1), 103-119, 2014 | 27 | 2014 |
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein JA Irving, E Miranda, I Haq, J Perez, VR Kotov, SV Faull, ... Biochemical Journal 468 (1), 99-108, 2015 | 18 | 2015 |
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour N Motamedi-Shad, AM Jagger, M Liedtke, SV Faull, AS Nanda, ... Biochemical Journal 473 (19), 3269-3290, 2016 | 15 | 2016 |
Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. Nat Commun 10: 3814 SV Faull, AMC Lau, C Martens, Z Ahdash, K Hansen, H Yebenes, ... | 5 | 2019 |
Cryo-EM Studies of Cullin-Ring Ubiquitin E3 Ligase (CRL) 2 Regulation by the COP9 Signalosome SV Faull, F Beuron, H Yebenes, A Lau, A Politis, EP Morris Biophysical Journal 112 (3), 578a, 2017 | 3 | 2017 |
Electrophoresis-and FRET-based measures of serpin polymerization SV Faull, AE Brown, I Haq, JA Irving Alpha-1 Antitrypsin Deficiency: Methods and Protocols, 235-248, 2017 | 2 | 2017 |
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates JN Wells, V Leber, LV Edwardes, S Allyjaun, M Peach, J Tomkins, ... bioRxiv, 2024.04. 11.589023, 2024 | | 2024 |
Structural characterisation of tissue-derived, disease-associated polymers of alpha-l-antitrypsin using conformation-selective antibodies and single-particle reconstructions … E Elliston, S Faull, M Laffranchi, B Gooptu, A Jagger, E Miranda, J Perez, ... EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 48, S127-S127, 2019 | | 2019 |
Structural characterisation of tissue-derived, disease-associated polymers of alpha-1-antitrypsin using conformation-selective antibodies and single-particle reconstructions … E Elliston, S Faull, M Laffranchi, B Gooptu, A Jagger, E Miranda, J Perez, ... EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 48, S49-S49, 2019 | | 2019 |
Stability and structural change in the pathological polymerisation of alpha 1-antitrypsin AM Jagger, E Elliston, EI Wroe, JL Wort, M Poeschla, A Nanda, ... EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46, S239, 2017 | | 2017 |
Native stability and the pathway of alpha 1-antitrypsin polymerisation JA Irving, I Haq, JA Dickens, SV Faull, DA Lomas FEBS JOURNAL 281, 146-146, 2014 | | 2014 |
Preventing pathogenic ordered aggregation of alpha 1-antitrypsin using an engineered single chain antibody fragment NM Shad, M Liedtke, SV Faull, J Perez, E Miranda, I Haq, JA Irving, ... FEBS JOURNAL 281, 155-155, 2014 | | 2014 |