| Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ... Molecular Therapy 24 (10), 1836-1847, 2016 | 451 | 2016 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic Acids Research 47 (3), 1070–1081, 2018 | 112 | 2018 |
| Visualization of self-delivering hydrophobically modified siRNA cellular internalization S Ly, DM Navaroli, MC Didiot, J Cardia, L Pandarinathan, JF Alterman, ... Nucleic Acids Research 45 (1), 15-25, 2016 | 95 | 2016 |
| Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin S Ly, SS Lehrer Biochemistry 51 (32), 6413-6420, 2012 | 60 | 2012 |
| CDKN2A/B T2D genome-wide association study risk SNPs impact locus gene expression and proliferation in human islets Y Kong, RB Sharma, S Ly, RE Stamateris, WM Jesdale, LC Alonso Diabetes 67 (5), 872-884, 2018 | 54 | 2018 |
| Nuclear localization of huntingtin mRNA is specific to cells of neuronal origin MC Didiot, CM Ferguson, S Ly, AH Coles, AO Smith, AA Bicknell, LM Hall, ... Cell reports 24 (10), 2553-2560. e5, 2018 | 45 | 2018 |
| Novel cluster and monomer-based GalNAc structures induce effective uptake of siRNAs in vitro and in vivo VK Sharma, MF Osborn, MR Hassler, D Echeverria, S Ly, EA Ulashchik, ... Bioconjugate chemistry 29 (7), 2478-2488, 2018 | 36 | 2018 |
| Cell type impacts accessibility of mRNA to silencing by RNA interference CM Ferguson, D Echeverria, M Hassler, S Ly, A Khvorova Molecular Therapy-Nucleic Acids 21, 384-393, 2020 | 28 | 2020 |
| Single-stranded phosphorothioated regions enhance cellular uptake of cholesterol-conjugated siRNA but not silencing efficacy S Ly, D Echeverria, J Sousa, A Khvorova Molecular Therapy-Nucleic Acids 21, 991-1005, 2020 | 23 | 2020 |
| Tropomyosin is in a reduced state in rabbit psoas muscle SS Lehrer, S Ly, F Fuchs Journal of muscle research and cell motility 32, 19-21, 2011 | 16 | 2011 |
| Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection VN Hariharan, M Shin, CW Chang, D O’Reilly, A Biscans, K Yamada, ... Proceedings of the National Academy of Sciences 120 (11), e2219523120, 2023 | 14 | 2023 |
| Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo A Biscans, S Ly, N McHugh, DA Cooper, A Khvorova Journal of Controlled Release 349, 831-843, 2022 | 14 | 2022 |
| Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease D O'Reilly, J Belgrad, C Ferguson, A Summers, E Sapp, C McHugh, ... Molecular Therapy 31 (6), 1661-1674, 2023 | 13 | 2023 |
| Tropomyosin is in a reduced state in rat cardiac muscle SS Lehrer, S Ly, F Fuchs Journal of muscle research and cell motility 32 (2), 63-64, 2011 | 13 | 2011 |
| Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains S Ly, MC Didiot, CM Ferguson, AH Coles, R Miller, K Chase, D Echeverria, ... Brain Communications 4 (6), fcac248, 2022 | 9 | 2022 |
| OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION A Khvorova, J Watts, Z Kennedy, A Biscans, BM da Cruz Godinho, ... US Patent App. 17/333,839, 2023 | 1 | 2023 |
| Methods and compositions for genomic integration D Getts, Y Wang, N Bisaria, I Shcherbakova, S Ly US Patent App. 18/313,087, 2023 | | 2023 |
| Methods and compositions for genomic integration D Getts, Y Wang, N Bisaria, I Shcherbakova, S Ly US Patent App. 18/313,126, 2023 | | 2023 |
| Methods and compositions for genomic integration D Getts, Y Wang, N Bisaria, I Shcherbakova, S Ly US Patent 11,672,874, 2023 | | 2023 |
| Methods and compositions for genomic integration D Getts, Y Wang, N Bisaria, I Shcherbakova, S Ly US Patent App. 18/157,052, 2023 | | 2023 |
