Christian Brendel
Christian Brendel
Dana-Farber/Boston Children's Hospital Cancer and Blood Disorders Center, Harvard Medical School
Verified email at childrens.harvard.edu
Title
Cited by
Cited by
Year
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor
K Schönfeld, C Sahm, C Zhang, S Naundorf, C Brendel, M Odendahl, ...
Molecular therapy 23 (2), 330-338, 2015
1592015
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
G Santilli, E Almarza, C Brendel, U Choi, C Beilin, MP Blundell, S Haria, ...
Molecular Therapy 19 (1), 122-132, 2011
1102011
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
912019
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype
C Brendel, S Guda, R Renella, DE Bauer, MC Canver, YJ Kim, ...
The Journal of clinical investigation 126 (10), 3868-3878, 2016
862016
Mammary epithelial reconstitution with gene‐modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor …
V Vafaizadeh, P Klemmt, C Brendel, K Weber, C Doebele, K Britt, M Grez, ...
Stem cells 28 (5), 928-938, 2010
832010
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction
S Guda, C Brendel, R Renella, P Du, DE Bauer, MC Canver, JK Grenier, ...
Molecular Therapy 23 (9), 1465-1474, 2015
792015
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
N Pfaff, N Lachmann, M Ackermann, S Kohlscheen, C Brendel, T Maetzig, ...
Stem Cells 31 (3), 488-499, 2013
712013
Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection
J Kimpel, SE Braun, G Qiu, FE Wong, M Conolle, JE Schmitz, C Brendel, ...
PLoS One 5 (8), e12357, 2010
582010
Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter
C Brendel, U Müller-Kuller, S Schultze-Strasser, S Stein, ...
Gene therapy 19 (10), 1018-1029, 2012
522012
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and …
U Müller-Kuller, M Ackermann, S Kolodziej, C Brendel, J Fritsch, ...
Nucleic acids research 43 (3), 1577-1592, 2015
452015
Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing
S Knight, F Zhang, U Mueller-Kuller, M Bokhoven, A Gupta, T Broughton, ...
Journal of virology 86 (17), 9088-9095, 2012
432012
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions
M Weisser, UM Demel, S Stein, L Chen-Wichmann, F Touzot, G Santilli, ...
Journal of Allergy and Clinical Immunology 138 (1), 219-228. e9, 2016
332016
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors
C Wichmann, IQL Coco, Ö Yildiz, L Chen-Wichmann, H Weber, ...
Leukemia 29 (2), 279-289, 2015
332015
Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing
KB Kaufmann, C Brendel, JD Suerth, U Mueller-Kuller, L Chen-Wichmann, ...
Molecular Therapy 21 (3), 648-661, 2013
312013
From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease
S Stein, S Scholz, J Schwäble, MA Sadat, U Modlich, S Schultze-Strasser, ...
Human Gene Therapy Clinical Development 24 (2), 86-98, 2013
302013
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells
C Brendel, B Goebel, A Daniela, M Brugman, S Kneissl, J Schwäble, ...
Molecular Therapy 23 (1), 63-70, 2015
262015
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells
C Brendel, B Goebel, A Daniela, M Brugman, S Kneissl, J Schwäble, ...
Molecular Therapy 23 (1), 63-70, 2015
262015
Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease
PM Altrock, C Brendel, R Renella, SH Orkin, DA Williams, F Michor
American journal of hematology 91 (9), 931-937, 2016
252016
CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells
SK Kays, KB Kaufmann, T Abel, C Brendel, H Bonig, M Grez, CJ Buchholz, ...
Stem cells and development 24 (6), 714-723, 2015
222015
The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells
A Weber, C Borghouts, C Brendel, R Moriggl, N Delis, B Brill, ...
Pharmaceuticals 6 (8), 960-987, 2013
222013
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