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Christian Brendel
Christian Brendel
Dana-Farber/Boston Children's Hospital Cancer and Blood Disorders Center, Harvard Medical School
Verified email at childrens.harvard.edu
Title
Cited by
Cited by
Year
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
4262019
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor
K Schönfeld, C Sahm, C Zhang, S Naundorf, C Brendel, M Odendahl, ...
Molecular therapy 23 (2), 330-338, 2015
3292015
Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
EB Esrick, LE Lehmann, A Biffi, M Achebe, C Brendel, MF Ciuculescu, ...
New England Journal of Medicine 384 (3), 205-215, 2021
3112021
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype
C Brendel, S Guda, R Renella, DE Bauer, MC Canver, YJ Kim, ...
The Journal of clinical investigation 126 (10), 3868-3878, 2016
1642016
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
G Santilli, E Almarza, C Brendel, U Choi, C Beilin, MP Blundell, S Haria, ...
Molecular Therapy 19 (1), 122-132, 2011
1602011
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction
S Guda, C Brendel, R Renella, P Du, DE Bauer, MC Canver, JK Grenier, ...
Molecular Therapy 23 (9), 1465-1474, 2015
1332015
Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor …
V Vafaizadeh, P Klemmt, C Brendel, K Weber, C Doebele, K Britt, M Grez, ...
Stem cells 28 (5), 928-938, 2010
1042010
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome
AL Kennedy, KC Myers, J Bowman, CJ Gibson, ND Camarda, E Furutani, ...
Nature communications 12 (1), 1334, 2021
1022021
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
N Pfaff, N Lachmann, M Ackermann, S Kohlscheen, C Brendel, T Maetzig, ...
Stem Cells 31 (3), 488-499, 2013
892013
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and …
U Müller-Kuller, M Ackermann, S Kolodziej, C Brendel, J Fritsch, ...
Nucleic acids research 43 (3), 1577-1592, 2015
872015
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions
M Weisser, UM Demel, S Stein, L Chen-Wichmann, F Touzot, G Santilli, ...
Journal of Allergy and Clinical Immunology 138 (1), 219-228. e9, 2016
762016
Editing aberrant splice sites efficiently restores β-globin expression in β-thalassemia
S Xu, K Luk, Q Yao, AH Shen, J Zeng, Y Wu, HY Luo, C Brendel, L Pinello, ...
Blood, The Journal of the American Society of Hematology 133 (21), 2255-2262, 2019
752019
Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection
J Kimpel, SE Braun, G Qiu, FE Wong, M Conolle, JE Schmitz, C Brendel, ...
PloS one 5 (8), e12357, 2010
682010
Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter
C Brendel, U Müller-Kuller, S Schultze-Strasser, S Stein, ...
Gene therapy 19 (10), 1018-1029, 2012
602012
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors
C Wichmann, I Quagliano-Lo Coco, Ö Yildiz, L Chen-Wichmann, H Weber, ...
Leukemia 29 (2), 279-289, 2015
552015
Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing
S Knight, F Zhang, U Mueller-Kuller, M Bokhoven, A Gupta, T Broughton, ...
Journal of virology 86 (17), 9088-9095, 2012
522012
Preclinical evaluation of a novel lentiviral vector driving lineage-specific BCL11A knockdown for sickle cell gene therapy
C Brendel, O Negre, M Rothe, S Guda, G Parsons, C Harris, ...
Molecular Therapy-Methods & Clinical Development 17, 589-600, 2020
492020
Surface functionalization of orthopedic titanium implants with bone sialoprotein
A Baranowski, A Klein, U Ritz, A Ackermann, J Anthonissen, ...
PLoS One 11 (4), e0153978, 2016
472016
Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease
C Brendel, M Rothe, G Santilli, S Charrier, S Stein, H Kunkel, D Abriss, ...
Human Gene Therapy Clinical Development 29 (2), 69-79, 2018
412018
Differential Transgene Silencing of Myeloid-Specific Promoters in the AAVS1 Safe Harbor Locus of Induced Pluripotent Stem Cell-Derived Myeloid Cells
D Klatt, E Cheng, D Hoffmann, G Santilli, AJ Thrasher, C Brendel, ...
Human Gene Therapy 31 (3-4), 199-210, 2020
382020
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