Christian Brendel
Christian Brendel
Dana-Farber/Boston Children's Hospital Cancer and Blood Disorders Center, Harvard Medical School
Verified email at childrens.harvard.edu
TitleCited byYear
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor
K Schönfeld, C Sahm, C Zhang, S Naundorf, C Brendel, M Odendahl, ...
Molecular therapy 23 (2), 330-338, 2015
1392015
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
G Santilli, E Almarza, C Brendel, U Choi, C Beilin, MP Blundell, S Haria, ...
Molecular Therapy 19 (1), 122-132, 2011
1082011
Mammary epithelial reconstitution with gene‐modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor …
V Vafaizadeh, P Klemmt, C Brendel, K Weber, C Doebele, K Britt, M Grez, ...
Stem cells 28 (5), 928-938, 2010
832010
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction
S Guda, C Brendel, R Renella, P Du, DE Bauer, MC Canver, JK Grenier, ...
Molecular Therapy 23 (9), 1465-1474, 2015
712015
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
N Pfaff, N Lachmann, M Ackermann, S Kohlscheen, C Brendel, T Maetzig, ...
Stem Cells 31 (3), 488-499, 2013
672013
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype
C Brendel, S Guda, R Renella, DE Bauer, MC Canver, YJ Kim, ...
The Journal of clinical investigation 126 (10), 3868-3878, 2016
662016
Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection
J Kimpel, SE Braun, G Qiu, FE Wong, M Conolle, JE Schmitz, C Brendel, ...
PloS one 5 (8), 2010
562010
Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter
C Brendel, U Müller-Kuller, S Schultze-Strasser, S Stein, ...
Gene therapy 19 (10), 1018-1029, 2012
522012
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
422019
Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing
S Knight, F Zhang, U Mueller-Kuller, M Bokhoven, A Gupta, T Broughton, ...
Journal of virology 86 (17), 9088-9095, 2012
422012
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and …
U Müller-Kuller, M Ackermann, S Kolodziej, C Brendel, J Fritsch, ...
Nucleic acids research 43 (3), 1577-1592, 2015
392015
From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease
S Stein, S Scholz, J Schwäble, MA Sadat, U Modlich, S Schultze-Strasser, ...
Human Gene Therapy Clinical Development 24 (2), 86-98, 2013
302013
Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing
KB Kaufmann, C Brendel, JD Suerth, U Mueller-Kuller, L Chen-Wichmann, ...
Molecular Therapy 21 (3), 648-661, 2013
302013
Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions
M Weisser, UM Demel, S Stein, L Chen-Wichmann, F Touzot, G Santilli, ...
Journal of Allergy and Clinical Immunology 138 (1), 219-228. e9, 2016
282016
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors
C Wichmann, IQL Coco, Ö Yildiz, L Chen-Wichmann, H Weber, ...
Leukemia 29 (2), 279-289, 2015
282015
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells
C Brendel, B Goebel, A Daniela, M Brugman, S Kneissl, J Schwäble, ...
Molecular Therapy 23 (1), 63-70, 2015
262015
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells
C Brendel, B Goebel, A Daniela, M Brugman, S Kneissl, J Schwäble, ...
Molecular Therapy 23 (1), 63-70, 2015
262015
Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease
PM Altrock, C Brendel, R Renella, SH Orkin, DA Williams, F Michor
American journal of hematology 91 (9), 931-937, 2016
242016
CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells
SK Kays, KB Kaufmann, T Abel, C Brendel, H Bonig, M Grez, CJ Buchholz, ...
Stem cells and development 24 (6), 714-723, 2015
222015
The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells
A Weber, C Borghouts, C Brendel, R Moriggl, N Delis, B Brill, ...
Pharmaceuticals 6 (8), 960-987, 2013
212013
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