| Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ... Science 369 (6508), eabc8511, 2020 | 1551 | 2020 |
| T-cell invigoration to tumour burden ratio associated with anti-PD-1 response AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ... Nature 545 (7652), 60-65, 2017 | 1485 | 2017 |
| TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion O Khan, JR Giles, S McDonald, S Manne, SF Ngiow, KP Patel, MT Werner, ... Nature 571 (7764), 211-218, 2019 | 1110 | 2019 |
| Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ... Science 354 (6316), 1160-1165, 2016 | 1110 | 2016 |
| Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ... Immunity 52 (5), 825-841. e8, 2020 | 581 | 2020 |
| A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma AC Huang, RJ Orlowski, X Xu, R Mick, SM George, PK Yan, S Manne, ... Nature medicine 25 (3), 454-461, 2019 | 556 | 2019 |
| TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision Z Chen, Z Ji, SF Ngiow, S Manne, Z Cai, AC Huang, J Johnson, ... Immunity 51 (5), 840-855. e5, 2019 | 490 | 2019 |
| Epigenomic-guided mass cytometry profiling reveals disease-specific features of exhausted CD8 T cells B Bengsch, T Ohtani, O Khan, M Setty, S Manne, S O’Brien, PF Gherardini, ... Immunity 48 (5), 1029-1045. e5, 2018 | 280 | 2018 |
| The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs AT Virtue, SJ McCright, JM Wright, MT Jimenez, WK Mowel, JJ Kotzin, ... Science translational medicine 11 (496), eaav1892, 2019 | 249 | 2019 |
| Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche SK Vadrevu, NK Chintala, SK Sharma, P Sharma, C Cleveland, ... Cancer research 74 (13), 3454-3465, 2014 | 183 | 2014 |
| Non-conventional inhibitory CD4+ Foxp3− PD-1hi T cells as a biomarker of immune checkpoint blockade activity R Zappasodi, S Budhu, MD Hellmann, MA Postow, Y Senbabaoglu, ... Cancer cell 33 (6), 1017-1032. e7, 2018 | 153 | 2018 |
| Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue M Buggert, S Nguyen, G Salgado-Montes de Oca, B Bengsch, S Darko, ... Science immunology 3 (24), eaar4526, 2018 | 147 | 2018 |
| Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation MS Abdel-Hakeem, S Manne, JC Beltra, E Stelekati, Z Chen, K Nzingha, ... Nature immunology 22 (8), 1008-1019, 2021 | 138 | 2021 |
| T follicular helper cells in human efferent lymph retain lymphoid characteristics LA Vella, M Buggert, S Manne, RS Herati, I Sayin, L Kuri-Cervantes, ... The Journal of clinical investigation 129 (8), 3185-3200, 2019 | 125 | 2019 |
| In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer Z Chen, E Arai, O Khan, Z Zhang, SF Ngiow, Y He, H Huang, S Manne, ... Cell 184 (5), 1262-1280. e22, 2021 | 116 | 2021 |
| UPenn COVID Processing Unit D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ... Deep immune profiling of COVID-19 patients reveals distinct immunotypes with …, 2020 | 97 | 2020 |
| Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity C Liu, A Somasundaram, S Manne, AM Gocher, AL Szymczak-Workman, ... Nature immunology 21 (9), 1010-1021, 2020 | 96 | 2020 |
| Long-term persistence of exhausted CD8 T cells in chronic infection is regulated by microRNA-155 E Stelekati, Z Chen, S Manne, M Kurachi, MA Ali, K Lewy, Z Cai, ... Cell reports 23 (7), 2142-2156, 2018 | 90 | 2018 |
| miR-150 regulates memory CD8 T cell differentiation via c-Myb Z Chen, E Stelekati, M Kurachi, S Yu, Z Cai, S Manne, O Khan, X Yang, ... Cell reports 20 (11), 2584-2597, 2017 | 79 | 2017 |
| Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics JR Giles, SF Ngiow, S Manne, AE Baxter, O Khan, P Wang, R Staupe, ... Nature immunology 23 (11), 1600-1613, 2022 | 76 | 2022 |
E. John WherryUniversity of PennsylvaniaVerified email at pennmedicine.upenn.edu
