AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA T Fernandes-Alnemri, JW Yu, P Datta, J Wu, ES Alnemri Nature 458 (7237), 509-513, 2009 | 2040 | 2009 |
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis SM Srinivasula, R Hegde, A Saleh, P Datta, E Shiozaki, J Chai, RA Lee, ... Nature 410 (6824), 112-116, 2001 | 1389 | 2001 |
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation T Fernandes-Alnemri, J Wu, JW Yu, P Datta, B Miller, W Jankowski, ... Cell Death & Differentiation 14 (9), 1590-1604, 2007 | 1161 | 2007 |
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis T Fernandes-Alnemri, JW Yu, C Juliana, L Solorzano, S Kang, J Wu, ... Nature immunology 11 (5), 385-393, 2010 | 835 | 2010 |
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1 SM Srinivasula, JL Poyet, M Razmara, P Datta, ZJ Zhang, ES Alnemri Journal of Biological Chemistry 277 (24), 21119-21122, 2002 | 710 | 2002 |
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome C Juliana, T Fernandes-Alnemri, J Wu, P Datta, L Solorzano, JW Yu, ... Journal of Biological Chemistry 285 (13), 9792-9802, 2010 | 602 | 2010 |
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway SM Srinivasula, P Datta, XJ Fan, T Fernandes-Alnemri, Z Huang, ... Journal of Biological Chemistry 275 (46), 36152-36157, 2000 | 481 | 2000 |
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice JM Jones, P Datta, SM Srinivasula, W Ji, S Gupta, ZJ Zhang, E Davies, ... Nature 425 (6959), 721-727, 2003 | 462 | 2003 |
Cryopyrin and pyrin activate caspase-1, but not NF-κ B, via ASC oligomerization JW Yu, J Wu, Z Zhang, P Datta, I Ibrahimi, S Taniguchi, J Sagara, ... Cell Death & Differentiation 13 (2), 236-249, 2006 | 449 | 2006 |
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants JW Yu, T Fernandes-Alnemri, P Datta, J Wu, C Juliana, L Solorzano, ... Molecular cell 28 (2), 214-227, 2007 | 327 | 2007 |
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2 SM Srinivasula, S Gupta, P Datta, ZJ Zhang, R Hegde, NE Cheong, ... Journal of biological chemistry 278 (34), 31469-31472, 2003 | 271 | 2003 |
The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity S Park, C Juliana, S Hong, P Datta, I Hwang, T Fernandes-Alnemri, JW Yu, ... The Journal of Immunology 191 (8), 4358-4366, 2013 | 268 | 2013 |
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein SM Srinivasula, P Datta, M Kobayashi, JW Wu, M Fujioka, R Hegde, ... Current biology 12 (2), 125-130, 2002 | 172 | 2002 |
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein R Hegde, SM Srinivasula, P Datta, M Madesh, R Wassell, ZJ Zhang, ... Journal of Biological Chemistry 278 (40), 38699-38706, 2003 | 122 | 2003 |
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity S Gupta, R Singh, P Datta, ZJ Zhang, C Orr, Z Lu, G DuBois, AS Zervos, ... Journal of Biological Chemistry 279 (44), 45844-45854, 2004 | 110 | 2004 |
Small terminase couples viral DNA binding to genome-packaging ATPase activity A Roy, A Bhardwaj, P Datta, GC Lander, G Cingolani Structure 20 (8), 1403-1413, 2012 | 81 | 2012 |
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging S Kang, JP Louboutin, P Datta, CP Landel, D Martinez, AS Zervos, ... Cell Death & Differentiation 20 (2), 259-269, 2013 | 76 | 2013 |
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila FS Khan, M Fujioka, P Datta, T Fernandes-Alnemri, JB Jaynes, ... Cell Death & Differentiation 15 (6), 1073-1083, 2008 | 33 | 2008 |
Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis Y Hashimoto, N Hosoda, P Datta, ES Alnemri, S Hoshino Apoptosis 17 (12), 1287-1299, 2012 | 17 | 2012 |
correction: a conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis SM Srinivasula, R Hegde, A Saleh, P Datta, E Shiozaki, J Chai, RA Lee, ... Nature 411 (6841), 1081-1081, 2001 | 10 | 2001 |