| Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 MG Ott, M Schmidt, K Schwarzwaelder, S Stein, U Siler, U Koehl, H Glimm, ... Nature medicine 12 (4), 401-409, 2006 | 1371 | 2006 |
| Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease S Stein, MG Ott, S Schultze-Strasser, A Jauch, B Burwinkel, A Kinner, ... Nature medicine 16 (2), 198-204, 2010 | 901 | 2010 |
| An unbiased genome-wide analysis of zinc-finger nuclease specificity R Gabriel, A Lombardo, A Arens, JC Miller, P Genovese, C Kaeppel, ... Nature biotechnology 29 (9), 816-823, 2011 | 720 | 2011 |
| Stem-cell gene therapy for the Wiskott–Aldrich syndrome K Boztug, M Schmidt, A Schwarzer, PP Banerjee, IA Díez, RA Dewey, ... New England Journal of Medicine 363 (20), 1918-1927, 2010 | 634 | 2010 |
| Gene therapy for Wiskott-Aldrich syndrome—long-term efficacy and genotoxicity CJ Braun, K Boztug, A Paruzynski, M Witzel, A Schwarzer, M Rothe, ... Science translational medicine 6 (227), 227ra33-227ra33, 2014 | 618 | 2014 |
| Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking J Weischenfeldt, T Dubash, AP Drainas, BR Mardin, Y Chen, AM Stütz, ... Nature genetics 49 (1), 65-74, 2017 | 377 | 2017 |
| High-resolution insertion-site analysis by linear amplification–mediated PCR (LAM-PCR) M Schmidt, K Schwarzwaelder, C Bartholomae, K Zaoui, C Ball, I Pilz, ... Nature methods 4 (12), 1051-1057, 2007 | 377 | 2007 |
| Distinct types of tumor-initiating cells form human colon cancer tumors and metastases SM Dieter, CR Ball, CM Hoffmann, A Nowrouzi, F Herbst, O Zavidij, ... Cell stem cell 9 (4), 357-365, 2011 | 349 | 2011 |
| Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G2/M transit and do not reenter G0 H Glimm, ILH Oh, CJ Eaves Blood, The Journal of the American Society of Hematology 96 (13), 4185-4193, 2000 | 323 | 2000 |
| Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ... The Journal of clinical investigation 117 (8), 2225-2232, 2007 | 294 | 2007 |
| BRAF inhibition in refractory hairy-cell leukemia S Dietrich, H Glimm, M Andrulis, C Von Kalle, AD Ho, T Zenz New England Journal of Medicine 366 (21), 2038-2040, 2012 | 288 | 2012 |
| Sarcoma classification by DNA methylation profiling C Koelsche, D Schrimpf, D Stichel, M Sill, F Sahm, DE Reuss, M Blattner, ... Nature communications 12 (1), 498, 2021 | 287 | 2021 |
| Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells O Voloshanenko, G Erdmann, TD Dubash, I Augustin, M Metzig, G Moffa, ... Nature communications 4 (1), 2610, 2013 | 276 | 2013 |
| Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-β2 microglobulin–null mice H Glimm, W Eisterer, K Lee, J Cashman, TL Holyoake, F Nicolini, ... The Journal of clinical investigation 107 (2), 199-206, 2001 | 241 | 2001 |
| Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo K Schwarzwaelder, SJ Howe, M Schmidt, MH Brugman, A Deichmann, ... The Journal of clinical investigation 117 (8), 2241-2249, 2007 | 239 | 2007 |
| Integrative genomic and transcriptomic analysis of leiomyosarcoma P Chudasama, SS Mughal, MA Sanders, D Hübschmann, I Chung, ... Nature communications 9 (1), 144, 2018 | 237 | 2018 |
| Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing A Paruzynski, A Arens, R Gabriel, CC Bartholomae, S Scholz, W Wang, ... Nature protocols 5 (8), 1379-1395, 2010 | 224 | 2010 |
| Comprehensive genomic access to vector integration in clinical gene therapy R Gabriel, R Eckenberg, A Paruzynski, CC Bartholomae, A Nowrouzi, ... Nature medicine 15 (12), 1431-1436, 2009 | 217 | 2009 |
| NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer C Heining, P Horak, S Uhrig, PL Codo, B Klink, B Hutter, M Fröhlich, ... Cancer discovery 8 (9), 1087-1095, 2018 | 216 | 2018 |
| A largely random AAV integration profile after LPLD gene therapy C Kaeppel, SG Beattie, R Fronza, R Van Logtenstein, F Salmon, ... Nature medicine 19 (7), 889-891, 2013 | 205 | 2013 |
