| Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra K Dührkop, LF Nothias, M Fleischauer, R Reher, M Ludwig, MA Hoffmann, ... Nature biotechnology 39 (4), 462-471, 2021 | 378 | 2021 |
| Lack of beta-arrestin signaling in the absence of active G proteins M Grundmann, N Merten, D Malfacini, A Inoue, P Preis, K Simon, ... Nature communications 9 (1), 341, 2018 | 364 | 2018 |
| NPClassifier: a deep neural network-based structural classification tool for natural products HW Kim, M Wang, CA Leber, LF Nothias, R Reher, KB Kang, ... Journal of Natural Products 84 (11), 2795-2807, 2021 | 167 | 2021 |
| A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products R Reher, HW Kim, C Zhang, HH Mao, M Wang, LF Nothias, ... Journal of the American Chemical Society 142 (9), 4114-4120, 2020 | 144 | 2020 |
| Direct targeting of Gαq and Gα11 oncoproteins in cancer cells S Annala, X Feng, N Shridhar, F Eryilmaz, J Patt, JH Yang, EM Pfeil, ... Science signaling 12 (573), eaau5948, 2019 | 105 | 2019 |
| A community resource for paired genomic and metabolomic data mining MA Schorn, S Verhoeven, L Ridder, F Huber, DD Acharya, AA Aksenov, ... Nature Chemical Biology 17 (4), 363-368, 2021 | 102 | 2021 |
| Heterologous expression, biosynthetic studies, and ecological function of the selective Gq‐signaling inhibitor FR900359 M Crüsemann, R Reher, I Schamari, AO Brachmann, T Ohbayashi, ... Angewandte Chemie International Edition 57 (3), 836-840, 2018 | 70 | 2018 |
| The genome analysis of Candidatus Burkholderia crenata reveals that secondary metabolism may be a key function of the Ardisia crenata leaf nodule symbiosis A Carlier, L Fehr, M Pinto‐Carbó, T Schäberle, R Reher, S Dessein, ... Environmental microbiology 18 (8), 2507-2522, 2016 | 70 | 2016 |
| Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain PD Boudreau, BW Miller, LI McCall, J Almaliti, R Reher, K Hirata, T Le, ... Journal of medicinal chemistry 62 (20), 9026-9044, 2019 | 44 | 2019 |
| Artificial intelligence for natural product drug discovery MW Mullowney, KR Duncan, SS Elsayed, N Garg, JJJ van der Hooft, ... Nature Reviews Drug Discovery 22 (11), 895-916, 2023 | 41 | 2023 |
| Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity D Malfacini, J Patt, S Annala, K Harpsøe, F Eryilmaz, R Reher, ... Journal of Biological Chemistry 294 (15), 5747-5758, 2019 | 39 | 2019 |
| Deciphering Specificity Determinants for FR900359‐Derived Gqα Inhibitors Based on Computational and Structure–Activity Studies R Reher, T Kühl, S Annala, T Benkel, D Kaufmann, B Nubbemeyer, ... ChemMedChem 13 (16), 1634-1643, 2018 | 34 | 2018 |
| Applying molecular networking for the detection of natural sources and analogues of the selective Gq protein inhibitor FR900359 R Reher, M Kuschak, N Heycke, S Annala, S Kehraus, HF Dai, ... Journal of natural products 81 (7), 1628-1635, 2018 | 31 | 2018 |
| Heterologous expression of cryptomaldamide in a cyanobacterial host A Taton, A Ecker, B Diaz, NA Moss, B Anderson, R Reher, TF Leão, ... ACS Synthetic Biology 9 (12), 3364-3376, 2020 | 30 | 2020 |
| Native metabolomics identifies the rivulariapeptolide family of protease inhibitors R Reher, AT Aron, P Fajtová, P Stincone, B Wagner, AI Pérez-Lorente, ... Nature communications 13 (1), 4619, 2022 | 26 | 2022 |
| A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria T Leão, M Wang, N Moss, R da Silva, J Sanders, S Nurk, A Gurevich, ... Marine drugs 19 (1), 20, 2021 | 25 | 2021 |
| Cell‐permeable high‐affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors M Kuschak, V Namasivayam, M Rafehi, JH Voss, J Garg, JG Schlegel, ... British journal of pharmacology 177 (8), 1898-1916, 2020 | 24 | 2020 |
| Structural and dynamical basis of G protein inhibition by YM-254890 and FR900359: an inhibitor in action D Tietze, D Kaufmann, AA Tietze, A Voll, R Reher, G König, F Hausch Journal of chemical information and modeling 59 (10), 4361-4373, 2019 | 23 | 2019 |
| A universal language for finding mass spectrometry data patterns AK Jarmusch, AT Aron, D Petras, VV Phelan, W Bittremieux, DD Acharya, ... bioRxiv, 2022.08. 06.503000, 2022 | 19 | 2022 |
| Lack of beta-arrestin signaling in the absence of active G proteins. Nat Commun 9: 341 M Grundmann, N Merten, D Malfacini, A Inoue, P Preis, K Simon, ... | 17 | 2018 |
William GerwickScripps Institution of Oceanography and Skaggs School of Pharmacy, UC San DiegoVerified email at ucsd.edu
