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Evan August Boyle
Evan August Boyle
Staff Scientist, Exai Bio
Verified email at exai.bio
Title
Cited by
Cited by
Year
An expanded view of complex traits: from polygenic to omnigenic
EA Boyle, YI Li, JK Pritchard
Cell 169 (7), 1177-1186, 2017
27262017
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
MR Mumbach, AT Satpathy, EA Boyle, C Dai, BG Gowen, SW Cho, ...
Nature genetics 49 (11), 1602-1612, 2017
4462017
Saturation editing of genomic regions by multiplex homology-directed repair
GM Findlay, EA Boyle, RJ Hause, JC Klein, J Shendure
Nature 513 (7516), 120-123, 2014
3922014
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer
RDA Weren, MJL Ligtenberg, CM Kets, RM De Voer, ETP Verwiel, ...
Nature genetics 47 (6), 668-671, 2015
3912015
Detection of human adaptation during the past 2000 years
Y Field, EA Boyle, N Telis, Z Gao, KJ Gaulton, D Golan, L Yengo, ...
Science 354 (6313), 760-764, 2016
3832016
Reduced signal for polygenic adaptation of height in UK Biobank
JJ Berg, A Harpak, N Sinnott-Armstrong, AM Joergensen, H Mostafavi, ...
Elife 8, e39725, 2019
3482019
Recurrent de novo mutations implicate novel genes underlying simplex autism risk
BJ O'roak, HA Stessman, EA Boyle, KT Witherspoon, B Martin, C Lee, ...
Nature communications 5 (1), 5595, 2014
3432014
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ...
Nature communications 8 (1), 15178, 2017
3292017
Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
AM D'Gama, Y Geng, JA Couto, B Martin, EA Boyle, CM LaCoursiere, ...
Annals of neurology 77 (4), 720-725, 2015
2892015
Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity
R Bachmann-Gagescu, JC Dempsey, IG Phelps, BJ O'roak, DM Knutzen, ...
Journal of medical genetics 52 (8), 514-522, 2015
2612015
Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism
GM Mirzaa, CD Campbell, N Solovieff, CP Goold, LA Jansen, S Menon, ...
JAMA neurology 73 (7), 836-845, 2016
2582016
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
G Wheway, M Schmidts, DA Mans, K Szymanska, TMT Nguyen, H Racher, ...
Nature cell biology 17 (8), 1074-1087, 2015
2442015
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
EA Boyle, JOL Andreasson, LM Chircus, SH Sternberg, MJ Wu, ...
Proceedings of the National Academy of Sciences 114 (21), 5461-5466, 2017
1962017
Multiplex homology-directed repair
J Shendure, E Boyle, G Findlay
US Patent App. 14/818,217, 2016
1962016
MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing
EA Boyle, BJ O’Roak, BK Martin, A Kumar, J Shendure
Bioinformatics 30 (18), 2670-2672, 2014
1752014
PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution
G Mirzaa, AE Timms, V Conti, EA Boyle, KM Girisha, B Martin, M Kircher, ...
JCI insight 1 (9), 2016
1602016
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
MS Haney, CJ Bohlen, DW Morgens, JA Ousey, AA Barkal, CK Tsui, ...
Nature genetics 50 (12), 1716-1727, 2018
1552018
De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay
JX Chong, MJ McMillin, KM Shively, AE Beck, CT Marvin, JR Armenteros, ...
The American Journal of Human Genetics 96 (3), 462-473, 2015
1352015
Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study
GM Mirzaa, V Conti, AE Timms, CD Smyser, S Ahmed, M Carter, S Barnett, ...
The Lancet Neurology 14 (12), 1182-1195, 2015
962015
Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
A Kumar, EA Boyle, M Tokita, AM Mikheev, MC Sanger, E Girard, ...
Genome biology 15, 1-9, 2014
832014
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Articles 1–20