| EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers DE Ehrnhoefer, J Bieschke, A Boeddrich, M Herbst, L Masino, R Lurz, ... Nature structural & molecular biology 15 (6), 558-566, 2008 | 1555 | 2008 |
| EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity J Bieschke, J Russ, RP Friedrich, DE Ehrnhoefer, H Wobst, ... Proceedings of the National Academy of Sciences 107 (17), 7710-7715, 2010 | 1073 | 2010 |
| Opposing activities protect against age-onset proteotoxicity E Cohen, J Bieschke, RM Perciavalle, JW Kelly, A Dillin Science 313 (5793), 1604-1610, 2006 | 985 | 2006 |
| Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils J Bieschke, M Herbst, T Wiglenda, RP Friedrich, A Boeddrich, F Schiele, ... Nature chemical biology 8 (1), 93-101, 2012 | 482 | 2012 |
| Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets J Bieschke, A Giese, W Schulz-Schaeffer, I Zerr, S Poser, M Eigen, ... Proceedings of the National Academy of Sciences 97 (10), 5468-5473, 2000 | 330 | 2000 |
| Structure–function–folding relationship in a WW domain M Jäger, Y Zhang, J Bieschke, H Nguyen, M Dendle, ME Bowman, ... Proceedings of the National Academy of Sciences 103 (28), 10648-10653, 2006 | 265 | 2006 |
| Kinetic investigations by fluorescence correlation spectroscopy: the analytical and diagnostic potential of diffusion studies P Schwille, J Bieschke, F Oehlenschläger Biophysical chemistry 66 (2-3), 211-228, 1997 | 259 | 1997 |
| Metabolite-initiated protein misfolding may trigger Alzheimer's disease Q Zhang, ET Powers, J Nieva, ME Huff, MA Dendle, J Bieschke, CG Glabe, ... Proceedings of the National Academy of Sciences 101 (14), 4752-4757, 2004 | 247 | 2004 |
| Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation H Mirbaha, BB Holmes, DW Sanders, J Bieschke, MI Diamond Journal of biological chemistry 290 (24), 14893-14903, 2015 | 239 | 2015 |
| The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios HJ Wobst, A Sharma, MI Diamond, EE Wanker, J Bieschke FEBS letters 589 (1), 77-83, 2015 | 219 | 2015 |
| The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation SJ Siegel, J Bieschke, ET Powers, JW Kelly Biochemistry 46 (6), 1503-1510, 2007 | 218 | 2007 |
| Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity A Koltermann, U Kettling, J Bieschke, T Winkler, M Eigen Proceedings of the National Academy of Sciences 95 (4), 1421-1426, 1998 | 211 | 1998 |
| Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers JML del Amo, U Fink, M Dasari, G Grelle, EE Wanker, J Bieschke, B Reif Journal of molecular biology 421 (4-5), 517-524, 2012 | 203 | 2012 |
| Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation J Bieschke, Q Zhang, ET Powers, RA Lerner, JW Kelly Biochemistry 44 (13), 4977-4983, 2005 | 171 | 2005 |
| Autocatalytic self-propagation of misfolded prion protein J Bieschke, P Weber, N Sarafoff, M Beekes, A Giese, H Kretzschmar Proceedings of the National Academy of Sciences 101 (33), 12207-12211, 2004 | 156 | 2004 |
| Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils G Grelle, A Otto, M Lorenz, RF Frank, EE Wanker, J Bieschke Biochemistry 50 (49), 10624-10636, 2011 | 145 | 2011 |
| Small molecule oxidation products trigger disease-associated protein misfolding JAN Bieschke, Q Zhang, DA Bosco, RA Lerner, ET Powers, P Wentworth, ... Accounts of chemical research 39 (9), 611-619, 2006 | 120 | 2006 |
| Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets U Bertsch, KF Winklhofer, T Hirschberger, J Bieschke, P Weber, FU Hartl, ... Journal of virology 79 (12), 7785-7791, 2005 | 113 | 2005 |
| Differential constitutive and activation‐dependent expression of prion protein in human peripheral blood leucocytes J Dürig, A Giese, W Schulz‐Schaeffer, C Rosenthal, U Schmücker, ... British journal of haematology 108 (3), 488-495, 2000 | 111 | 2000 |
| Amyloid-β (1–42) aggregation initiates its cellular uptake and cytotoxicity S Jin, N Kedia, E Illes-Toth, I Haralampiev, S Prisner, A Herrmann, ... Journal of Biological Chemistry 291 (37), 19590-19606, 2016 | 108 | 2016 |
Armin GieseProfessor for Neuropathology, Ludwig-Maximilians-Universität München; CSO MODAG GmbHVerified email at modag.net
