Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure YC Ho, L Shan, NN Hosmane, J Wang, SB Laskey, DIS Rosenbloom, ... Cell 155 (3), 540-551, 2013 | 1477 | 2013 |
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation L Shan, K Deng, NS Shroff, CM Durand, SA Rabi, HC Yang, H Zhang, ... Immunity 36 (3), 491-501, 2012 | 846 | 2012 |
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations K Deng, M Pertea, A Rongvaux, L Wang, CM Durand, G Ghiaur, J Lai, ... Nature 517 (7534), 381-385, 2015 | 573 | 2015 |
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells S Zhu, S Ding, P Wang, Z Wei, W Pan, NW Palm, Y Yang, H Yu, HB Li, ... Nature 546 (7660), 667-670, 2017 | 312 | 2017 |
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation HC Yang, S Xing, L Shan, K O’Connell, J Dinoso, A Shen, Y Zhou, ... The Journal of clinical investigation 119 (11), 3473-3486, 2009 | 298 | 2009 |
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity NG Ring, D Herndler-Brandstetter, K Weiskopf, L Shan, JP Volkmer, ... Proceedings of the National Academy of Sciences 114 (49), E10578-E10585, 2017 | 262 | 2017 |
Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation S Xing, CK Bullen, NS Shroff, L Shan, HC Yang, JL Manucci, S Bhat, ... Journal of virology 85 (12), 6060-6064, 2011 | 237 | 2011 |
Transcriptional reprogramming during effector-to-memory transition renders CD4+ T cells permissive for latent HIV-1 infection L Shan, K Deng, H Gao, S Xing, AA Capoferri, CM Durand, SA Rabi, ... Immunity 47 (4), 766-775. e3, 2017 | 196 | 2017 |
Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance SA Rabi, GM Laird, CM Durand, S Laskey, L Shan, JR Bailey, S Chioma, ... The Journal of clinical investigation 123 (9), 3848-3860, 2013 | 183 | 2013 |
Subsets of ILC3− ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues M Cella, R Gamini, C Sécca, PL Collins, S Zhao, V Peng, ML Robinette, ... Nature immunology 20 (8), 980-991, 2019 | 178 | 2019 |
Humanized mouse model supports development, function, and tissue residency of human natural killer cells D Herndler-Brandstetter, L Shan, Y Yao, C Stecher, V Plajer, ... Proceedings of the National Academy of Sciences 114 (45), E9626-E9634, 2017 | 169 | 2017 |
Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model L Shan, HC Yang, SA Rabi, HC Bravo, NS Shroff, RA Irizarry, H Zhang, ... Journal of virology 85 (11), 5384-5393, 2011 | 147 | 2011 |
HIV-1 DNA Is Detected in Bone Marrow Populations Containing CD4+ T Cells but Is not Found in Purified CD34+ Hematopoietic Progenitor Cells in Most Patients … CM Durand, G Ghiaur, JD Siliciano, SA Rabi, EE Eisele, M Salgado, ... Journal of Infectious Diseases 205 (6), 1014-1018, 2012 | 133 | 2012 |
HIV latency and integration site placement in five cell-based models S Sherrill-Mix, MK Lewinski, M Famiglietti, A Bosque, N Malani, ... Retrovirology 10, 1-14, 2013 | 119 | 2013 |
A novel PCR assay for quantification of HIV-1 RNA L Shan, SA Rabi, GM Laird, EE Eisele, H Zhang, JB Margolick, ... Journal of virology 87 (11), 6521-6525, 2013 | 113 | 2013 |
From reactivation of latent HIV‐1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication L Shan, RF Siliciano Bioessays 35 (6), 544-552, 2013 | 102 | 2013 |
CARD8 is an inflammasome sensor for HIV-1 protease activity Q Wang, H Gao, KM Clark, CS Mugisha, K Davis, JP Tang, GH Harlan, ... Science 371 (6535), eabe1707, 2021 | 98 | 2021 |
Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4 J Zhu, G Liao, L Shan, J Zhang, MR Chen, GS Hayward, SD Hayward, ... Journal of virology 83 (10), 5219-5231, 2009 | 82 | 2009 |
A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs L Shen, SA Rabi, AR Sedaghat, L Shan, J Lai, S Xing, RF Siliciano Science translational medicine 3 (91), 91ra63-91ra63, 2011 | 71 | 2011 |
Sprouty-2 regulates HIV-specific T cell polyfunctionality YL Chiu, L Shan, H Huang, C Haupt, C Bessell, DH Canaday, H Zhang, ... The Journal of clinical investigation 124 (1), 198-208, 2014 | 60 | 2014 |