Oliver Werz
Oliver Werz
Professor for Pharmaceutical Chemistry, Friedrich Schiller University Jena
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5-Lipoxygenase: regulation of expression and enzyme activity
O Rådmark, O Werz, D Steinhilber, B Samuelsson
Trends in biochemical sciences 32 (7), 332-341, 2007
5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
O Rådmark, O Werz, D Steinhilber, B Samuelsson
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2015
Boswellia serrata: An Overall Assessment of In Vitro, Preclinical, Pharmacokinetic and Clinical Data
M Abdel-Tawab, O Werz, M Schubert-Zsilavecz
Clinical pharmacokinetics 50, 349-369, 2011
The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human b lymphocytes (∗)
D Steinhilber, M Brungs, O Werz, I Wiesenberg, C Danielsson, JP Kahlen, ...
Journal of Biological Chemistry 270 (13), 7037-7040, 1995
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase
D Albert, I Zündorf, T Dingermann, WE Müller, D Steinhilber, O Werz
Biochemical pharmacology 64 (12), 1767-1775, 2002
Therapeutic options for 5-lipoxygenase inhibitors
O Werz, D Steinhilber
Pharmacology & therapeutics 112 (3), 701-718, 2006
Multi-target approach for natural products in inflammation
A Koeberle, O Werz
Drug discovery today 19 (12), 1871-1882, 2014
Boswellic acids: biological actions and molecular targets
D Poeckel, O Werz
Current medicinal chemistry 13 (28), 3359-3369, 2006
5-lipoxygenase: cellular biology and molecular pharmacology
O Werz
Current Drug Targets-Inflammation & Allergy 1 (1), 23-44, 2002
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
O Werz, J Klemm, B Samuelsson, O Rådmark
Proceedings of the National Academy of Sciences 97 (10), 5261-5266, 2000
Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity
O Werz, J Gerstmeier, S Libreros, X De la Rosa, M Werner, PC Norris, ...
Nature communications 9 (1), 59, 2018
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes
O Werz, E Bürkert, B Samuelsson, O Rådmark, D Steinhilber
Blood, The Journal of the American Society of Hematology 99 (3), 1044-1052, 2002
ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma
C Pergola, G Dodt, A Rossi, E Neunhoeffer, B Lawrenz, H Northoff, ...
Proceedings of the National Academy of Sciences 105 (50), 19881-19886, 2008
5-Lipoxygenase inhibitors: a review of recent developments and patents
C Pergola, O Werz
Expert opinion on therapeutic patents 20 (3), 355-375, 2010
Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin
O Werz
Planta medica 73 (13), 1331-1357, 2007
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1
A Koeberle, U Siemoneit, U Bühring, H Northoff, S Laufer, W Albrecht, ...
Journal of Pharmacology and Experimental Therapeutics 326 (3), 975-982, 2008
Extracellular signal‐regulated kinases phosphorylate 5lipoxygenase and stimulate 5‐lipoxygenase product formation in leukocytes
O Werz, E Bürkert, L Fischer, D Szellas, D Dishart, B Samuelsson, ...
The FASEB Journal 16 (11), 1441-1443, 2002
Development of 5-lipoxygenase inhibitors—lessons from cellular enzyme regulation
O Werz, D Steinhilber
Biochemical pharmacology 70 (3), 327-333, 2005
Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
D Poeckel, C Greiner, M Verhoff, O Rau, L Tausch, C Hörnig, ...
Biochemical pharmacology 76 (1), 91-97, 2008
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
O Werz, D Szellas, D Steinhilber, O Rådmark
Journal of biological chemistry 277 (17), 14793-14800, 2002
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