Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance J König, AT Nies, Y Cui, I Leier, D Keppler Biochimica et Biophysica Acta (BBA)-Biomembranes 1461 (2), 377-394, 1999 | 989 | 1999 |
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells Y Cui, J König, U Buchholz, H Spring, I Leier, D Keppler Molecular Pharmacology 55 (5), 929-937, 1999 | 880 | 1999 |
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane J König, Y Cui, AT Nies, D Keppler American Journal of Physiology-Gastrointestinal and Liver Physiology 278 (1 …, 2000 | 763 | 2000 |
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide J König, Y Cui, AT Nies, D Keppler Journal of Biological Chemistry 275 (30), 23161-23168, 2000 | 641 | 2000 |
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 Y Cui, J König, I Leier, U Buchholz, D Keppler Journal of Biological Chemistry 276 (13), 9626-9630, 2001 | 627 | 2001 |
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane J König, D Rost, Y Cui, D Keppler Hepatology 29 (4), 1156-1163, 1999 | 608 | 1999 |
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2 Y Cui, J König, D Keppler Molecular Pharmacology 60 (5), 934-943, 2001 | 260 | 2001 |
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2 T Kamisako, I Leier, Y Cui, J König, U Buchholz, J Hummel‐Eisenbeiss, ... Hepatology 30 (2), 485-490, 1999 | 232 | 1999 |
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2 I Leier, J Hummel-Eisenbeiss, Y Cui, D Keppler Kidney international 57 (4), 1636-1642, 2000 | 195 | 2000 |
A Naturally Occurring Mutation in the SLC21A6Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter C Michalski, Y Cui, AT Nies, AK Nuessler, P Neuhaus, UM Zanger, ... Journal of Biological Chemistry 277 (45), 43058-43063, 2002 | 174 | 2002 |
Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma Y Cui, J König, AT Nies, M Pfannschmidt, M Hergt, WW Franke, W Alt, ... Laboratory investigation 83 (4), 527-538, 2003 | 150 | 2003 |
Export pumps for anionic conjugates encoded by MRP genes D Keppler, Y Cui, J König, I Leier, A Nies Advances in enzyme regulation 39 (1), 237-246, 1999 | 121 | 1999 |
Characterization of the 5′‐flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 … B Stöckel, J König, AT Nies, Y Cui, M Brom, D Keppler European Journal of Biochemistry 267 (5), 1347-1358, 2000 | 119 | 2000 |
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins T Fehrenbach, Y Cui, H Faulstich, D Keppler Naunyn-Schmiedeberg's archives of pharmacology 368, 415-420, 2003 | 118 | 2003 |
Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers L Liu, Y Cui, AY Chung, Y Shitara, Y Sugiyama, D Keppler, KS Pang Journal of Pharmacology and Experimental Therapeutics 318 (1), 395-402, 2006 | 117 | 2006 |
Somatostatin receptor subtype 4 (SSTR4) agonists R Giovannini, Y Cui, H Doods, M Ferrara, J Stefan, R Kuelzer, I Lingard, ... US Patent 10,166,214, 2019 | 107* | 2019 |
Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3) YMA Lee, Y Cui, J König, A Risch, B Jäger, P Drings, H Bartsch, ... Pharmacogenetics and Genomics 14 (4), 213-223, 2004 | 92 | 2004 |
Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family D Keppler Adv Enzyme Regul 40, 339-349, 2000 | 86 | 2000 |
Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2) AT Nies, J König, Y Cui, M Brom, H Spring, D Keppler European journal of biochemistry 269 (7), 1866-1876, 2002 | 83 | 2002 |
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo C Kofink, N Trainor, B Mair, S Wöhrle, M Wurm, N Mischerikow, MJ Roy, ... Nature Communications 13 (1), 5969, 2022 | 82 | 2022 |