| Global landscape of HIV–human protein complexes S Jaeger, P Cimermancic, N Gulbahce, JR Johnson, KE McGovern, ... Nature 481 (7381), 365-370, 2012 | 781 | 2012 |
| The structure–function linkage database E Akiva, S Brown, DE Almonacid, AE Barber 2nd, AF Custer, MA Hicks, ... Nucleic acids research 42 (D1), D521-D530, 2013 | 243 | 2013 |
| Evolutionary conservation of domain-domain interactions Z Itzhaki, E Akiva, Y Altuvia, H Margalit Genome Biology 7 (12), R125, 2006 | 122 | 2006 |
| Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain GL Holliday, E Akiva, EC Meng, SD Brown, S Calhoun, U Pieper, A Sali, ... Academic Press, 2018 | 120 | 2018 |
| Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily E Akiva, JN Copp, N Tokuriki, PC Babbitt Proceedings of the National Academy of Sciences 114 (45), E9549-E9558, 2017 | 119 | 2017 |
| Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics CJ Markin, DA Mokhtari, F Sunden, MJ Appel, E Akiva, S Longwell, ... bioRxiv, 2020 | 110 | 2020 |
| Built-in loops allow versatility in domain–domain interactions: lessons from self-interacting domains E Akiva, Z Itzhaki, H Margalit Proceedings of the National Academy of Sciences 105 (36), 13292-13297, 2008 | 108 | 2008 |
| Large-Scale Determination of Sequence, Structure, and Function Relationships in Cytosolic Glutathione Transferases across the Biosphere ST Mashiyama, MM Malabanan, E Akiva, R Bhosle, MC Branch, ... PLoS Biology 12 (4), e1001843, 2014 | 100 | 2014 |
| Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks S Zhao, A Sakai, X Zhang, MW Vetting, R Kumar, B Hillerich, ... Elife 3, 2014 | 95 | 2014 |
| Parallel molecular mechanisms for enzyme temperature adaptation MM Pinney, DA Mokhtari, E Akiva, F Yabukarski, DM Sanchez, R Liang, ... Science 371 (6533), 2021 | 71 | 2021 |
| A dynamic view of domain-motif interactions E Akiva, G Friedlander, Z Itzhaki, H Margalit PLoS computational biology 8 (1), e1002341, 2012 | 71 | 2012 |
| Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks JN Copp, E Akiva, PC Babbitt, N Tokuriki Biochemistry, 2018 | 68 | 2018 |
| [FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis JN Betz, NW Boswell, CJ Fugate, GL Holliday, E Akiva, AG Scott, ... Biochemistry 54 (9), 1807-1818, 2015 | 60 | 2015 |
| A global view of structure–function relationships in the tautomerase superfamily R Davidson, BJ Baas, E Akiva, GL Holliday, BJ Polacco, JA LeVieux, ... Journal of Biological Chemistry 293 (7), 2342-2357, 2018 | 46 | 2018 |
| Evaluating functional annotations of enzymes using the gene ontology GL Holliday, R Davidson, E Akiva, PC Babbitt The Gene Ontology Handbook, 111-132, 2017 | 24 | 2017 |
| Prediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein design E Humphris-Narayanan, E Akiva, R Varela, SÓ Conchúir, T Kortemme PLoS computational biology 8 (8), e1002639, 2012 | 24 | 2012 |
| Exploring the sequence, function, and evolutionary space of protein superfamilies using sequence similarity networks and phylogenetic reconstructions JN Copp, DW Anderson, E Akiva, PC Babbitt, N Tokuriki Methods in enzymology 620, 315-347, 2019 | 20 | 2019 |
| Preferential use of protein domain pairs as interaction mediators: order and transitivity Z Itzhaki, E Akiva, H Margalit Bioinformatics 26 (20), 2564-2570, 2010 | 13 | 2010 |
| Human SIRT1 multi-specificity is modulated by active-site vicinity substitutions during natural evolution A Hendler, E Akiva, M Sandhu, D Goldberg, E Arbely, CJ Jackson, ... Molecular Biology and Evolution, 2020 | 11 | 2020 |
| Structural, kinetic, and mechanistic analysis of an asymmetric 4-oxalocrotonate tautomerase trimer BJ Baas, BP Medellin, JA LeVieux, M de Ruijter, YJ Zhang, SD Brown, ... Biochemistry 58 (22), 2617-2627, 2019 | 7 | 2019 |
Patricia BabbittProfessorVerified email at cgl.ucsf.edu
