Timothy A. Whitehead
Timothy A. Whitehead
Associate Professor, University of Colorado
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Zitiert von
Zitiert von
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
SJ Fleishman, TA Whitehead, DC Ekiert, C Dreyfus, JE Corn, EM Strauch, ...
Science 332 (6031), 816-821, 2011
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
TA Whitehead, A Chevalier, Y Song, C Dreyfus, SJ Fleishman, ...
Nature biotechnology 30 (6), 543-548, 2012
Community-wide assessment of protein-interface modeling suggests improvements to design methodology
SJ Fleishman, TA Whitehead, EM Strauch, JE Corn, S Qin, HX Zhou, ...
Journal of molecular biology 414 (2), 289-302, 2011
Mechanical nanosensor based on fret within a thermosome: Damage‐reporting polymeric materials
N Bruns, K Pustelny, LM Bergeron, TA Whitehead, DS Clark
Angewandte Chemie 121 (31), 5776-5779, 2009
Plasmid-based one-pot saturation mutagenesis
EE Wrenbeck, JR Klesmith, JA Stapleton, A Adeniran, KEJ Tyo, ...
Nature methods 13 (11), 928-930, 2016
Lignin triggers irreversible cellulase loss during pretreated lignocellulosic biomass saccharification
D Gao, C Haarmeyer, V Balan, TA Whitehead, BE Dale, SPS Chundawat
Biotechnology for biofuels 7 (1), 1-13, 2014
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck, R Michalczyk, TA Whitehead
Proceedings of the National Academy of Sciences 114 (9), 2265-2270, 2017
Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
EE Wrenbeck, LR Azouz, TA Whitehead
Nature communications 8 (1), 1-10, 2017
Deep sequencing methods for protein engineering and design
EE Wrenbeck, MS Faber, TA Whitehead
Current opinion in structural biology 45, 36-44, 2017
Minimal protein-folding systems in hyperthermophilic archaea
P Laksanalamai, TA Whitehead, FT Robb
Nature Reviews Microbiology 2 (4), 315-324, 2004
The interrelationship between promoter strength, gene expression, and growth rate
MS Bienick, KW Young, JR Klesmith, EE Detwiler, KJ Tomek, ...
PloS one 9 (10), e109105, 2014
Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non‐lethal cold shock
BB Boonyaratanakornkit, AJ Simpson, TA Whitehead, CM Fraser, ...
Environmental Microbiology 7 (6), 789-797, 2005
Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing
CA Kowalsky, MS Faber, A Nath, HE Dann, VW Kelly, L Liu, P Shanker, ...
Journal of Biological Chemistry 290 (44), 26457-26470, 2015
High-resolution sequence-function mapping of full-length proteins
CA Kowalsky, JR Klesmith, JA Stapleton, V Kelly, N Reichkitzer, ...
PloS one 10 (3), e0118193, 2015
Comprehensive Sequence-Flux Mapping of a Levoglucosan Utilization Pathway in E. coli
JR Klesmith, JP Bacik, R Michalczyk, TA Whitehead
ACS synthetic biology 4 (11), 1235-1243, 2015
Hotspot-centric de novo design of protein binders
SJ Fleishman, JE Corn, EM Strauch, TA Whitehead, J Karanicolas, ...
Journal of molecular biology 413 (5), 1047-1062, 2011
Self‐renaturing enzymes: design of an enzyme‐chaperone chimera as a new approach to enzyme stabilization
LM Bergeron, L Gomez, TA Whitehead, DS Clark
Biotechnology and bioengineering 102 (5), 1316-1322, 2009
A filamentous molecular chaperone of the prefoldin family from the deep‐sea hyperthermophile Methanocaldococcus jannaschii
TA Whitehead, BB Boonyaratanakornkit, V Höllrigl, DS Clark
Protein science 16 (4), 626-634, 2007
Computational design of novel protein binders and experimental affinity maturation
TA Whitehead, D Baker, SJ Fleishman
Methods in enzymology 523, 1-19, 2013
Tying up the loose ends: circular permutation decreases the proteolytic susceptibility of recombinant proteins
TA Whitehead, LM Bergeron, DS Clark
Protein Engineering, Design & Selection 22 (10), 607-613, 2009
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