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Florian Hollfelder
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Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology
AB Theberge, F Courtois, Y Schaerli, M Fischlechner, C Abell, F Hollfelder, ...
Angewandte Chemie International Edition 49 (34), 5846-5868, 2010
10972010
Microdroplets: a sea of applications?
A Huebner, S Sharma, M Srisa-Art, F Hollfelder, JB Edel, AJ Demello
Lab on a Chip 8 (8), 1244-1254, 2008
7352008
Quantitative detection of protein expression in single cells using droplet microfluidics
A Huebner, M Srisa-Art, D Holt, C Abell, F Hollfelder, AJ Demello, JB Edel
Chemical communications, 1218-1220, 2007
4052007
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays
A Huebner, D Bratton, G Whyte, M Yang, AJ Demello, C Abell, F Hollfelder
Lab on a Chip 9 (5), 692-698, 2009
3932009
Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets
Y Schaerli, RC Wootton, T Robinson, V Stein, C Dunsby, MAA Neil, ...
Analytical chemistry 81 (1), 302-306, 2009
3442009
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics
PY Colin, B Kintses, F Gielen, CM Miton, G Fischer, MF Mohamed, ...
Nature communications 6 (1), 1-12, 2015
2312015
Development of quantitative cell-based enzyme assays in microdroplets
A Huebner, LF Olguin, D Bratton, G Whyte, WTS Huck, AJ De Mello, ...
Analytical chemistry 80 (10), 3890-3896, 2008
2272008
What makes an enzyme promiscuous?
A Babtie, N Tokuriki, F Hollfelder
Current opinion in chemical biology 14 (2), 200-207, 2010
2232010
Picoliter cell lysate assays in microfluidic droplet compartments for directed enzyme evolution
B Kintses, C Hein, MF Mohamed, M Fischlechner, F Courtois, C Lainé, ...
Chemistry & biology 19 (8), 1001-1009, 2012
2192012
Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays
F Courtois, LF Olguin, G Whyte, AB Theberge, WTS Huck, F Hollfelder, ...
Analytical chemistry 81 (8), 3008-3016, 2009
2182009
Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation
KP Nightingale, S Gendreizig, DA White, C Bradbury, F Hollfelder, ...
Journal of Biological Chemistry 282 (7), 4408-4416, 2007
2072007
Microfluidic droplets: new integrated workflows for biological experiments
B Kintses, LD van Vliet, SRA Devenish, F Hollfelder
Current opinion in chemical biology 14 (5), 548-555, 2010
2062010
The role of protein dynamics in the evolution of new enzyme function
E Campbell, M Kaltenbach, GJ Correy, PD Carr, BT Porebski, ...
Nature chemical biology 12 (11), 944-950, 2016
2052016
An integrated device for monitoring time‐dependent in vitro expression from single genes in picolitre droplets
F Courtois, LF Olguin, G Whyte, D Bratton, WTS Huck, C Abell, ...
ChemBioChem 9 (3), 439-446, 2008
2002008
One in a million: flow cytometric sorting of single cell-lysate assays in monodisperse picolitre double emulsion droplets for directed evolution
A Zinchenko, SRA Devenish, B Kintses, PY Colin, M Fischlechner, ...
Analytical chemistry 86 (5), 2526-2533, 2014
1922014
The potential of microfluidic water-in-oil droplets in experimental biology
Y Schaerli, F Hollfelder
Molecular Biosystems 5 (12), 1392-1404, 2009
1922009
Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays
J Shim, RT Ranasinghe, CA Smith, SM Ibrahim, F Hollfelder, WTS Huck, ...
ACS nano 7 (7), 5955-5964, 2013
1912013
Off-the-shelf proteins that rival tailor-made antibodies as catalysts
F Hollfelder, AJ Kirby, DS Tawfik
Nature 383 (6595), 60-63, 1996
1911996
Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)
F Gielen, R Hours, S Emond, M Fischlechner, U Schell, F Hollfelder
Proceedings of the National Academy of Sciences 113 (47), E7383-E7389, 2016
1902016
Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments
J Shim, LF Olguin, G Whyte, D Scott, A Babtie, C Abell, WTS Huck, ...
Journal of the American Chemical Society 131 (42), 15251-15256, 2009
1842009
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