|Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions|
AP Bracken, N Dietrich, D Pasini, KH Hansen, K Helin
Genes & development 20 (9), 1123-1136, 2006
|EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer|
AP Bracken, D Pasini, M Capra, E Prosperini, E Colli, K Helin
The EMBO journal 22 (20), 5323-5335, 2003
|UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development|
K Agger, PAC Cloos, J Christensen, D Pasini, S Rose, J Rappsilber, ...
Nature 449 (7163), 731, 2007
|TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity|
K Williams, J Christensen, MT Pedersen, JV Johansen, PAC Cloos, ...
Nature 473 (7347), 343, 2011
|E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis|
H Müller, AP Bracken, R Vernell, MC Moroni, F Christians, E Grassilli, ...
Genes & development 15 (3), 267-285, 2001
|Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity|
D Pasini, AP Bracken, MR Jensen, EL Denchi, K Helin
The EMBO journal 23 (20), 4061-4071, 2004
|The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells|
AP Bracken, D Kleine-Kohlbrecher, N Dietrich, D Pasini, G Gargiulo, ...
Genes & development 21 (5), 525-530, 2007
|The putative oncogene GASC1 demethylates tri-and dimethylated lysine 9 on histone H3|
PAC Cloos, J Christensen, K Agger, A Maiolica, J Rappsilber, T Antal, ...
Nature 442 (7100), 307, 2006
|Apaf-1 is a transcriptional target for E2F and p53|
MC Moroni, ES Hickman, EL Denchi, G Caprara, E Colli, F Cecconi, ...
Nature cell biology 3 (6), 552, 2001
|A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F|
K Helin, JA Lees, M Vidal, N Dyson, E Harlow, A Fattaey
Cell 70 (2), 337-350, 1992
|The polycomb group protein Suz12 is required for embryonic stem cell differentiation|
D Pasini, AP Bracken, JB Hansen, M Capillo, K Helin
Molecular and cellular biology 27 (10), 3769-3779, 2007
|Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease|
PAC Cloos, J Christensen, K Agger, K Helin
Genes & development 22 (9), 1115-1140, 2008
|Molecular mechanisms and potential functions of histone demethylases|
SM Kooistra, K Helin
Nature reviews Molecular cell biology 13 (5), 297, 2012
|A model for transmission of the H3K27me3 epigenetic mark|
KH Hansen, AP Bracken, D Pasini, N Dietrich, SS Gehani, A Monrad, ...
Nature cell biology 10 (11), 1291, 2008
|Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.|
L Zhu, S van den Heuvel, K Helin, A Fattaey, M Ewen, D Livingston, ...
Genes & development 7 (7a), 1111-1125, 1993
|Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.|
K Helin, E Harlow, A Fattaey
Molecular and cellular biology 13 (10), 6501-6508, 1993
|Transcriptional regulation by Polycomb group proteins|
L Di Croce, K Helin
Nature structural & molecular biology 20 (10), 1147, 2013
|Regulation of cell proliferation by the E2F transcription factors|
Current opinion in genetics & development 8 (1), 28-35, 1998
|Polycomb group proteins: navigators of lineage pathways led astray in cancer|
AP Bracken, K Helin
Nature Reviews Cancer 9 (11), 773, 2009
|Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.|
K Helin, CL Wu, AR Fattaey, JA Lees, BD Dynlacht, C Ngwu, E Harlow
Genes & Development 7 (10), 1850-1861, 1993