Stefan Rose-John
Stefan Rose-John
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Zitiert von
Zitiert von
The pro-and anti-inflammatory properties of the cytokine interleukin-6
J Scheller, A Chalaris, D Schmidt-Arras, S Rose-John
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (5), 878-888, 2011
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
S Grivennikov, E Karin, J Terzic, D Mucida, GY Yu, S Vallabhapurapu, ...
Cancer cell 15 (2), 103-113, 2009
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis …
R Atreya, J Mudter, S Finotto, J Müllberg, T Jostock, S Wirtz, M Schütz, ...
Nature medicine 6 (5), 583-588, 2000
Soluble receptors for cytokines and growth factors: generation and biological function
S Rose-John, PC Heinrich
Biochemical Journal 300 (2), 281-290, 1994
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
SM Hurst, TS Wilkinson, RM McLoughlin, S Jones, S Horiuchi, ...
Immunity 14 (6), 705-714, 2001
TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
C Becker, MC Fantini, C Schramm, HA Lehr, S Wirtz, A Nikolaev, J Burg, ...
Immunity 21 (4), 491-501, 2004
Interleukin‐6 biology is coordinated by membrane‐bound and soluble receptors: role in inflammation and cancer
S Rose‐John, J Scheller, G Elson, SA Jones
Journal of leukocyte biology 80 (2), 227-236, 2006
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
S Rose-John
International journal of biological sciences 8 (9), 1237, 2012
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
C Hundhausen, D Misztela, TA Berkhout, N Broadway, P Saftig, K Reiss, ...
Blood 102 (4), 1186-1195, 2003
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
M Lesina, MU Kurkowski, K Ludes, S Rose-John, M Treiber, G Klöppel, ...
Cancer cell 19 (4), 456-469, 2011
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
SA Jones, J Scheller, S Rose-John
The Journal of clinical investigation 121 (9), 3375-3383, 2011
Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses
T Jostock, J Müllberg, S Özbek, R Atreya, G Blinn, N Voltz, M Fischer, ...
European journal of biochemistry 268 (1), 160-167, 2001
Transcriptional profiling identifies Id2 function in dendritic cell development
C Hacker, RD Kirsch, XS Ju, T Hieronymus, TC Gust, C Kuhl, T Jorgas, ...
Nature immunology 4 (4), 380-386, 2003
The soluble interleukin‐6 receptor is generated by shedding
J Mülberg, H Schooltink, T Stoyan, M Günther, L Graeve, G Buse, ...
European journal of immunology 23 (2), 473-480, 1993
Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors
J Arribas, L Coodly, P Vollmer, TK Kishimoto, S Rose-John, J Massagué
Journal of Biological Chemistry 271 (19), 11376-11382, 1996
Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
DT Teachey, SF Lacey, PA Shaw, JJ Melenhorst, SL Maude, N Frey, ...
Cancer discovery 6 (6), 664-679, 2016
A bioactive designer cytokine for human hematopoietic progenitor cell expansion
M Fischer, J Goldschmitt, C Peschel, JPG Brakenhoff, KJ Kallen, ...
Nature biotechnology 15 (2), 142-145, 1997
ADAM17: a molecular switch to control inflammation and tissue regeneration
J Scheller, A Chalaris, C Garbers, S Rose-John
Trends in immunology 32 (8), 380-387, 2011
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
V Matthews, B Schuster, S Schütze, I Bussmeyer, A Ludwig, ...
Journal of biological chemistry 278 (40), 38829-38839, 2003
The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
A Doganci, T Eigenbrod, N Krug, GT De Sanctis, M Hausding, ...
The Journal of clinical investigation 115 (2), 313-325, 2005
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