Andrew Buller
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Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme
CK Prier, RK Zhang, AR Buller, S Brinkmann-Chen, FH Arnold
Nature chemistry 9 (7), 629-634, 2017
A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome
AG Bassuk, RH Wallace, A Buhr, AR Buller, Z Afawi, M Shimojo, S Miyata, ...
The American Journal of Human Genetics 83 (5), 572-581, 2008
Enzyme-controlled nitrogen-atom transfer enables regiodivergent C–H amination
TK Hyster, CC Farwell, AR Buller, JA McIntosh, FH Arnold
Journal of the American Chemical Society 136 (44), 15505-15508, 2014
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
AR Buller, CA Townsend
Proceedings of the National Academy of Sciences 110 (8), E653-E661, 2013
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
AR Buller, S Brinkmann-Chen, DK Romney, M Herger, J Murciano-Calles, ...
Proceedings of the National Academy of Sciences 112 (47), 14599-14604, 2015
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
RD Lewis, M Garcia-Borrās, MJ Chalkley, AR Buller, KN Houk, SBJ Kan, ...
Proceedings of the National Academy of Sciences 115 (28), 7308-7313, 2018
Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble
AR Buller, P Van Roye, JKB Cahn, RA Scheele, M Herger, FH Arnold
Journal of the American Chemical Society 140 (23), 7256-7266, 2018
Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis
DR Marous, EP Lloyd, AR Buller, KA Moshos, TL Grove, AJ Blaszczyk, ...
Proceedings of the National Academy of Sciences 112 (33), 10354-10358, 2015
Synthesis of β-branched tryptophan analogues using an engineered subunit of tryptophan synthase
M Herger, P van Roye, DK Romney, S Brinkmann-Chen, AR Buller, ...
Journal of the American Chemical Society 138 (27), 8388-8391, 2016
A panel of TrpB biocatalysts derived from tryptophan synthase through the transfer of mutations that mimic allosteric activation
J Murciano‐Calles, DK Romney, S Brinkmann‐Chen, AR Buller, ...
Angewandte Chemie International Edition 55 (38), 11577-11581, 2016
Engineered biosynthesis of β‐alkyl tryptophan analogues
CE Boville, RA Scheele, P Koch, S Brinkmann‐Chen, AR Buller, ...
Angewandte Chemie 130 (45), 14980-14984, 2018
Structural adaptability facilitates histidine heme ligation in a cytochrome P450
JA McIntosh, T Heel, AR Buller, L Chio, FH Arnold
Journal of the American Chemical Society 137 (43), 13861-13865, 2015
Tryptophan synthase uses an atypical mechanism to achieve substrate specificity
AR Buller, P van Roye, J Murciano-Calles, FH Arnold
Biochemistry 55 (51), 7043-7046, 2016
Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction
JM Ellis, ME Campbell, P Kumar, EP Geunes, CA Bingman, AR Buller
Nature catalysis 5 (2), 136-143, 2022
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate
P Kumar, A Meza, JM Ellis, GA Carlson, CA Bingman, AR Buller
ACS chemical biology 16 (1), 86-95, 2020
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases
JKB Cahn, S Brinkmann-Chen, T Spatzal, JA Wiig, AR Buller, O Einsle, ...
Biochemical Journal 468 (3), 475-484, 2015
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement
AR Buller, MF Freeman, NT Wright, JF Schildbach, CA Townsend
Proceedings of the National Academy of Sciences 109 (7), 2308-2313, 2012
Facile in vitro biocatalytic production of diverse tryptamines
AD McDonald, LJ Perkins, AR Buller
ChemBioChem 20 (15), 1939-1944, 2019
Site-selective deuteration of amino acids through dual-protein catalysis
TJ Doyon, AR Buller
Journal of the American Chemical Society 144 (16), 7327-7336, 2022
Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions
KD Patel, FB d’Andrea, NM Gaudelli, AR Buller, CA Townsend, AM Gulick
Nature Communications 10 (1), 3868, 2019
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Articles 1–20