| The genetic determinants of the CYP3A5 polymorphism E Hustert, M Haberl, O Burk, R Wolbold, YQ He, K Klein, AC Nuessler, ... Pharmacogenetics and Genomics 11 (9), 773-779, 2001 | 855 | 2001 |
| Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation UM Zanger, M Turpeinen, K Klein, M Schwab Analytical and bioanalytical chemistry 392 (6), 1093-1108, 2008 | 758 | 2008 |
| Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver T Lang, K Klein, J Fischer, AK Nüssler, P Neuhaus, U Hofmann, ... Pharmacogenetics and Genomics 11 (5), 399-415, 2001 | 714 | 2001 |
| Sex is a major determinant of CYP3A4 expression in human liver R Wolbold, K Klein, O Burk, AK Nüssler, P Neuhaus, M Eichelbaum, ... Hepatology 38 (4), 978-988, 2003 | 621 | 2003 |
| Sex Is a Major Determinant in Human R Wolbold, K Klein, O Burk, AK Nussler, P Neuhaus, M Schwab, ... HEPATOLOGY 38 (4), 2003 | 621* | 2003 |
| Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group M Schwab, UM Zanger, C Marx, E Schaeffeler, K Klein, J Dippon, R Kerb, ... Journal of clinical oncology 26 (13), 2131-2138, 2008 | 488 | 2008 |
| Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver AT Nies, H Koepsell, S Winter, O Burk, K Klein, R Kerb, UM Zanger, ... Hepatology 50 (4), 1227-1240, 2009 | 458 | 2009 |
| Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance UM Zanger, K Klein Frontiers in genetics 4, 24, 2013 | 348 | 2013 |
| Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance UM Zanger, K Klein, T Saussele, J Blievernicht, M H Hofmann, M Schwab Future Medicine Ltd 8 (7), 743-759, 2007 | 320 | 2007 |
| Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with … K Klein, T Lang, T Saussele, E Barbosa-Sicard, WH Schunck, ... Pharmacogenetics and genomics 15 (12), 861-873, 2005 | 315 | 2005 |
| Interindividual variability of canalicular ATP‐binding‐cassette (ABC)–transporter expression in human liver Y Meier, C Pauli‐Magnus, UM Zanger, K Klein, E Schaeffeler, AK Nussler, ... Hepatology 44 (1), 62-74, 2006 | 276 | 2006 |
| Aberrant splicing caused by single nucleotide polymorphism c. 516G> T [Q172H], a marker of CYP2B6* 6, is responsible for decreased expression and activity of CYP2B6 in liver MH Hofmann, JK Blievernicht, K Klein, T Saussele, E Schaeffeler, ... Journal of Pharmacology and Experimental Therapeutics 325 (1), 284-292, 2008 | 275 | 2008 |
| Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro Z Desta, T Saussele, B Ward, J Blievernicht, L Li, K Klein, DA Flockhart, ... Future Medicine Ltd 8 (6), 547-558, 2007 | 273 | 2007 |
| Pharmacogenomics of cytochrome P450 3A4: recent progress toward the “missing heritability” problem K Klein, UM Zanger Frontiers in genetics 4, 12, 2013 | 259 | 2013 |
| Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine O Burk, H Tegude, I Koch, E Hustert, R Wolbold, H Glaeser, K Klein, ... Journal of Biological Chemistry 277 (27), 24280-24288, 2002 | 254 | 2002 |
| A novel intronic mutation, 2988G> A, with high predictivity for impaired dunction of cytochrome P450 2D6 in white subjects S Raimundo, C Toscano, K Klein, J Fischer, EU Griese, M Eichelbaum, ... Clinical Pharmacology & Therapeutics 76 (2), 128-138, 2004 | 237 | 2004 |
| Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver N Kassner, K Huse, HJ Martin, U Gödtel-Armbrust, A Metzger, I Meineke, ... Drug Metabolism and Disposition 36 (10), 2113-2120, 2008 | 227 | 2008 |
| Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease Y Zhang, K Klein, A Sugathan, N Nassery, A Dombkowski, UM Zanger, ... PloS one 6 (8), e23506, 2011 | 201 | 2011 |
| PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo K Klein, M Thomas, S Winter, AK Nussler, M Niemi, M Schwab, ... Clinical Pharmacology & Therapeutics 91 (6), 1044-1052, 2012 | 182 | 2012 |
| A Naturally Occurring Mutation in the SLC21A6Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter C Michalski, Y Cui, AT Nies, AK Nuessler, P Neuhaus, UM Zanger, ... Journal of Biological Chemistry 277 (45), 43058-43063, 2002 | 177 | 2002 |
