Max Horlbeck
Max Horlbeck
Boston Children's Hospital
Verified email at
TitleCited byYear
Genome-scale CRISPR-mediated control of gene repression and activation
LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ...
Cell 159 (3), 647-661, 2014
A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response
B Adamson, TM Norman, M Jost, MY Cho, JK Nu˝ez, Y Chen, JE Villalta, ...
Cell 167 (7), 1867-1882. e21, 2016
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
MC Bassik, M Kampmann, RJ Lebbink, S Wang, MY Hein, I Poser, ...
Cell 152 (4), 909-922, 2013
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
SJ Liu, MA Horlbeck, SW Cho, HS Birk, M Malatesta, D He, FJ Attenello, ...
Science 355 (6320), eaah7111, 2017
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
MA Horlbeck, LA Gilbert, JE Villalta, B Adamson, RA Pak, Y Chen, ...
Elife 5, e19760, 2016
CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs
MA Mandegar, N Huebsch, EB Frolov, E Shin, A Truong, MP Olvera, ...
Cell stem cell 18 (4), 541-553, 2016
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
MA Horlbeck, LB Witkowsky, B Guglielmi, JM Replogle, LA Gilbert, ...
elife 5, e12677, 2016
Single-cell analysis of long non-coding RNAs in the developing human neocortex
SJ Liu, TJ Nowakowski, AA Pollen, JH Lui, MA Horlbeck, FJ Attenello, ...
Genome biology 17 (1), 67, 2016
ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p
A Čopič, CF Latham, MA Horlbeck, JG D’Arcangelo, EA Miller
Science 335 (6074), 1359-1362, 2012
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
RM Deans, DW Morgens, A Íkesli, S Pillay, MA Horlbeck, M Kampmann, ...
Nature chemical biology 12 (5), 361, 2016
Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element
SW Cho, J Xu, R Sun, MR Mumbach, AC Carter, YG Chen, KE Yost, J Kim, ...
Cell 173 (6), 1398-1412. e22, 2018
Next-generation libraries for robust RNA interference-based genome-wide screens
M Kampmann, MA Horlbeck, Y Chen, JC Tsai, MC Bassik, LA Gilbert, ...
Proceedings of the National Academy of Sciences 112 (26), E3384-E3391, 2015
Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent
M Jost, Y Chen, LA Gilbert, MA Horlbeck, L Krenning, G Menchon, A Rai, ...
Molecular cell 68 (1), 210-223. e6, 2017
Mapping the genetic landscape of human cells
MA Horlbeck, A Xu, M Wang, NK Bennett, CY Park, D Bogdanoff, ...
Cell 174 (4), 953-967. e22, 2018
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
CJ Braun, PM Bruno, MA Horlbeck, LA Gilbert, JS Weissman, MT Hemann
Proceedings of the National Academy of Sciences 113 (27), E3892-E3900, 2016
Crispr/cas transcriptional modulation
LA Gilbert, M Horlbeck, M Kampmann, SQI Lei, JS Weissman
US Patent App. 15/326,428, 2017
Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform
KJ Wangensteen, YJ Wang, Z Dou, AW Wang, E Mosleh‐Shirazi, ...
Hepatology 68 (2), 663-676, 2018
Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins
AJ Martinko, C Truillet, O Julien, JE Diaz, MA Horlbeck, G Whiteley, ...
Elife 7, e31098, 2018
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure
BA Mendelsohn, NK Bennett, MA Darch, K Yu, MK Nguyen, D Pucciarelli, ...
PLoS biology 16 (8), e2004624, 2018
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
Z Yu, LE Surface, CY Park, MA Horlbeck, GA Wyant, M Abu-Remaileh, ...
Elife 7, e36620, 2018
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