| Structure of a modular polyketide synthase S Dutta, JR Whicher, DA Hansen, WA Hale, JA Chemler, GR Congdon, ... Nature 510 (7506), 512-517, 2014 | 373 | 2014 |
| Structural rearrangements of a polyketide synthase module during its catalytic cycle JR Whicher, S Dutta, DA Hansen, WA Hale, JA Chemler, AM Dosey, ... Nature 510 (7506), 560-564, 2014 | 217 | 2014 |
| Evolution of a highly active and enantiospecific metalloenzyme from short peptides S Studer, DA Hansen, ZL Pianowski, PRE Mittl, A Debon, SL Guffy, ... Science 362 (6420), 1285-1288, 2018 | 134 | 2018 |
| Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis JR Whicher, SS Smaga, DA Hansen, WC Brown, WH Gerwick, ... Chemistry & biology 20 (11), 1340-1351, 2013 | 118 | 2013 |
| Nonribosomal biosynthesis of backbone-modified peptides DL Niquille, DA Hansen, T Mori, D Fercher, H Kries, D Hilvert Nature chemistry 10 (3), 282-287, 2018 | 108 | 2018 |
| Directing group-controlled regioselectivity in an enzymatic C–H bond oxygenation S Negretti, ARH Narayan, KC Chiou, PM Kells, JL Stachowski, ... Journal of the American Chemical Society 136 (13), 4901-4904, 2014 | 78 | 2014 |
| Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ... ACS chemical biology 12 (1), 114-123, 2017 | 77 | 2017 |
| Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin DA Hansen, CM Rath, EB Eisman, ARH Narayan, JD Kittendorf, ... Journal of the American Chemical Society 135 (30), 11232-11238, 2013 | 76 | 2013 |
| Evolution of efficient modular polyketide synthases by homologous recombination JA Chemler, A Tripathi, DA Hansen, M O’Neil-Johnson, RB Williams, ... Journal of the American Chemical Society 137 (33), 10603-10609, 2015 | 49 | 2015 |
| A single active site mutation in the pikromycin thioesterase generates a more effective macrocyclization catalyst AA Koch, DA Hansen, VV Shende, LR Furan, KN Houk, G Jiménez-Osés, ... Journal of the American Chemical Society 139 (38), 13456-13465, 2017 | 47 | 2017 |
| Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides MM Almutairi, SR Park, S Rose, DA Hansen, N Vázquez-Laslop, ... Proceedings of the National Academy of Sciences 112 (42), 12956-12961, 2015 | 35 | 2015 |
| Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins MM Almutairi, MS Svetlov, DA Hansen, NF Khabibullina, D Klepacki, ... Nucleic acids research 45 (16), 9573-9582, 2017 | 33 | 2017 |
| Identification of a thioesterase bottleneck in the pikromycin pathway through full-module processing of unnatural pentaketides DA Hansen, AA Koch, DH Sherman Journal of the American Chemical Society 139 (38), 13450-13455, 2017 | 30 | 2017 |
| Substrate controlled divergence in polyketide synthase catalysis DA Hansen, AA Koch, DH Sherman Journal of the American Chemical Society 137 (11), 3735-3738, 2015 | 28 | 2015 |
| Biocatalytic synthesis of α-amino ketones SW Chun, ARH Narayan Synlett 30 (11), 1269-1274, 2019 | 21 | 2019 |
| Triple molecular target approach to selective melanoma cytotoxicity EB Skibo, A Jamil, B Austin, D Hansen, A Ghodousi Organic & Biomolecular Chemistry 8 (7), 1577-1587, 2010 | 15 | 2010 |
| Probing selectivity and creating structural diversity through hybrid polyketide synthases AA Koch, JJ Schmidt, AN Lowell, DA Hansen, KM Coburn, JA Chemler, ... Angewandte Chemie 132 (32), 13677-13682, 2020 | 13 | 2020 |
| Reprogramming nonribosomal peptide synthesis by surgical mutation DL Niquille, DA Hansen, D Hilvert Synlett 30 (19), 2123-2130, 2019 | 9 | 2019 |
| High-throughput reprogramming of an NRPS condensation domain IB Folger, NF Frota, A Pistofidis, DL Niquille, DA Hansen, TM Schmeing, ... Nature Chemical Biology, 1-9, 2024 | 4 | 2024 |
| ENGINEERING POLYKETIDE MOLECULAR GLUES B Pang, E Crull, P Hawkins, J Wong, D Hansen, R Estrela, H Roth, ... 4th International Conference on Natural Product Discovery and Development in …, 2023 | | 2023 |
