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Jan Schlender
Jan Schlender
Bestätigte E-Mail-Adresse bei novartis.com - Startseite
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Applied concepts in PBPK modeling: how to build a PBPK/PD model
L Kuepfer, C Niederalt, T Wendl, JF Schlender, S Willmann, J Lippert, ...
CPT: pharmacometrics & systems pharmacology 5 (10), 516-531, 2016
2972016
Development of a whole-body physiologically based pharmacokinetic approach to assess the pharmacokinetics of drugs in elderly individuals
JF Schlender, M Meyer, K Thelen, M Krauss, S Willmann, T Eissing, ...
Clinical pharmacokinetics 55, 1573-1589, 2016
1082016
Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
J Lippert, R Burghaus, A Edginton, S Frechen, M Karlsson, A Kovar, ...
CPT: pharmacometrics & systems pharmacology 8 (12), 878, 2019
732019
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim
S Basu, YTK Lien, V Vozmediano, JF Schlender, T Eissing, S Schmidt, ...
Frontiers in Pharmacology 11, 868, 2020
302020
Predictive Pediatric Modeling and Simulation Using Ontogeny Information
I Ince, J Solodenko, S Frechen, A Dallmann, C Niederalt, J Schlender, ...
The Journal of Clinical Pharmacology 59, S95-S103, 2019
302019
A physiologically-based pharmacokinetic model to describe ciprofloxacin pharmacokinetics over the entire span of life
JF Schlender, D Teutonico, K Coboeken, K Schnizler, T Eissing, ...
Clinical Pharmacokinetics 57, 1613-1634, 2018
292018
Current strategies to streamline pharmacotherapy for older adults
JF Schlender, V Vozmediano, AG Golden, M Rodriguez, TS Samant, ...
European Journal of Pharmaceutical Sciences 111, 432-442, 2018
182018
Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment
R Fendt, U Hofmann, ARP Schneider, E Schaeffeler, R Burghaus, ...
CPT: pharmacometrics & systems pharmacology 10 (7), 782-793, 2021
162021
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations
M Krauss, U Hofmann, C Schafmayer, S Igel, J Schlender, C Mueller, ...
NPJ systems biology and applications 3 (1), 11, 2017
162017
Predictive Performance of Physiology‐Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small‐Molecule Compounds in Children
I Ince, A Dallmann, S Frechen, K Coboeken, C Niederalt, T Wendl, ...
The Journal of Clinical Pharmacology 61, S70-S82, 2021
152021
Arzneimittelinteraktionen im Alter
K Bitter, JF Schlender, R Woltersdorf
Der Internist 7 (57), 728-734, 2016
122016
Geriatrics 2030: Developing Drugs to Care for Older Persons—A Neglected and Growing Population
SWJ Lau, JF Schlender, PW Slattum, DL Heald, R O'Connor‐Semmes
Clinical Pharmacology & Therapeutics 107 (1), 53-56, 2020
112020
Early prediction of decompensation (EPOD) score: Non‐invasive determination of cirrhosis decompensation risk
ARP Schneider, CV Schneider, KM Schneider, V Baier, S Schaper, ...
Liver International 42 (3), 640-650, 2022
72022
Improving therapeutics to better care for older adults and the young: report from the American College of Clinical Pharmacology workshop
SWJ Lau, JF Schlender, DR Abernethy, GJ Burckart, A Golden, ...
Journal of clinical pharmacology 58 (3), 277-280, 2018
62018
Drug–drug interactions in the elderly: Which ones really matter?
K Bitter, JF Schlender, R Woltersdorf
Der Internist 57, 728-734, 2016
42016
Physiologically Based Pharmacokinetic (PBPK) Modelling of Oral Drug Absorption in Older Adults–an AGePOP review
C Demeester, D Robins, AE Edwina, J Tournoy, P Augustijns, I Ince, ...
European Journal of Pharmaceutical Sciences, 106496, 2023
32023
The personalization of drug therapy for elderly patients
JF Schlender, AG Golden, TS Samant, CV Lagishetty, S Schmidt
Developing Drug Products in an Aging Society: From Concept to Prescribing …, 2016
32016
PBPK Modelling of Intracellular Drug Delivery Through Active and Passive Transport Processes
L Kuepfer, C Niederalt, T Wendl, JF Schlender, M Block, T Eissing, ...
Intracellular Delivery III: Market Entry Barriers of Nanomedicines, 363-374, 2016
32016
PHYSIOLOGICALLY-BASED PHARMACOKINETIC AND CLINICAL STUDY TO ASSESS EFFECTS OF CYP3A INDUCTION AND INHIBITION ON COPANLISIB PK IN CANCER PATIENTS.
JF Schlender, J Grevel, S Frechen, C Diedrich, R Burghaus, A Spreafico, ...
CLINICAL PHARMACOLOGY & THERAPEUTICS 105, S70-S70, 2019
22019
Physiologically-based pharmacokinetic modeling to inform dosing regimens and routes of administration of rifampicin and colistin combination against Acinetobacter baumannii
J Zhang, C Song, M Wu, J Yue, S Zhu, P Zhu, OO Charles, JF Schlender, ...
European Journal of Pharmaceutical Sciences 185, 106443, 2023
12023
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