Dr. Nachiket Vartak
Dr. Nachiket Vartak
Group Leader
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
G Zimmermann, B Papke, S Ismail, N Vartak, A Chandra, M Hoffmann, ...
Nature 497 (7451), 638-642, 2013
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins
O Rocks, M Gerauer, N Vartak, S Koch, ZP Huang, M Pechlivanis, ...
Cell 141 (3), 458-471, 2010
Small-molecule inhibition of APT1 affects Ras localization and signaling
FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ...
Nature chemical biology 6 (6), 449-456, 2010
The ascending pathophysiology of cholestatic liver disease
PLM Jansen, A Ghallab, N Vartak, R Reif, FG Schaap, J Hampe, ...
Hepatology 65 (2), 722-738, 2017
KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport
M Schmick, N Vartak, B Papke, M Kovacevic, DC Truxius, L Rossmannek, ...
Cell 157 (2), 459-471, 2014
Cholestasis-induced adaptive remodeling of interlobular bile ducts
N Vartak, A Damle-Vartak, B Richter, O Dirsch, U Dahmen, S Hammad, ...
Hepatology 63 (3), 951–964, 2016
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
W Albrecht, F Kappenberg, T Brecklinghaus, R Stoeber, R Marchan, ...
Archives of toxicology 93, 1609-1637, 2019
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ...
Hepatology 69 (2), 666-683, 2019
The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins
N Vartak, B Papke, HE Grecco, L Rossmannek, H Waldmann, C Hedberg, ...
Biophysical journal 106 (1), 93-105, 2014
Development of highly potent inhibitors of the Ras‐targeting human acyl protein thioesterases based on substrate similarity design
C Hedberg, FJ Dekker, M Rusch, S Renner, S Wetzel, N Vartak, ...
Angewandte Chemie 123 (42), 10006-10011, 2011
miRs-138 and-424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL
V Berg, M Rusch, N Vartak, C Jüngst, A Schauss, H Waldmann, ...
Blood, The Journal of the American Society of Hematology 125 (19), 2948-2957, 2015
Regulation of Ras localization by acylation enables a mode of intracellular signal propagation
A Lorentzen, A Kinkhabwala, O Rocks, N Vartak, PIH Bastiaens
Science signaling 3 (140), ra68-ra68, 2010
Single cell polarity in liquid phase facilitates tumour metastasis
A Lorentzen, PF Becker, J Kosla, M Saini, K Weidele, P Ronchi, C Klein, ...
Nature communications 9 (1), 887, 2018
Spatial cycles in G‐protein crowd control
N Vartak, P Bastiaens
The EMBO journal 29 (16), 2689-2699, 2010
Intravital dynamic and correlative imaging of mouse livers reveals diffusion‐dominated canalicular and flow‐augmented ductular bile flux
N Vartak, G Guenther, F Joly, A Damle‐Vartak, G Wibbelt, J Fickel, S Jörs, ...
Hepatology 73 (4), 1531-1550, 2021
Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis, which is associated with proliferating cells
R Reif, A Adawy, N Vartak, J Schröder, G Günther, A Ghallab, M Schmidt, ...
Journal of Biological Chemistry 291 (8), 3837-3847, 2016
Chemical‐Biological Exploration of the Limits of the Ras De‐and Repalmitoylating Machinery
K Görmer, M Bürger, JAW Kruijtzer, I Vetter, N Vartak, L Brunsveld, ...
ChemBioChem 13 (7), 1017-1023, 2012
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
T Brecklinghaus, W Albrecht, F Kappenberg, J Duda, N Vartak, K Edlund, ...
Chemico-biological interactions 351, 109728, 2022
On the mechanisms of biliary flux
N Vartak, D Drasdo, F Geisler, T Itoh, R PJ Oude Elferink, ...
Hepatology 74 (6), 3497-3512, 2021
Pipe-3D: a pipeline based on immunofluorescence, 3D confocal imaging, reconstructions, and morphometry for biliary network analysis in cholestasis
A Damle-Vartak, B Begher-Tibbe, G Gunther, F Geisler, N Vartak, ...
Experimental Cholestasis Research, 25-53, 2019
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