| PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 C Kondapalli, A Kazlauskaite, N Zhang, HI Woodroof, DG Campbell, ... Open biology 2 (5), 120080, 2012 | 918 | 2012 |
| Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases M Zhuang, MF Calabrese, J Liu, MB Waddell, A Nourse, M Hammel, ... Molecular cell 36 (1), 39-50, 2009 | 474 | 2009 |
| Types of ubiquitin ligases FE Morreale, H Walden Cell 165 (1), 248-248. e1, 2016 | 408 | 2016 |
| Autoregulation of Parkin activity through its ubiquitin‐like domain VK Chaugule, L Burchell, KR Barber, A Sidhu, SJ Leslie, GS Shaw, ... The EMBO journal 30 (14), 2853-2867, 2011 | 359 | 2011 |
| Ubiquitin signalling in DNA replication and repair HD Ulrich, H Walden Nature reviews Molecular cell biology 11 (7), 479-489, 2010 | 334 | 2010 |
| RBR E3 ubiquitin ligases: new structures, new insights, new questions DE Spratt, H Walden, GS Shaw Biochemical journal 458 (3), 421-437, 2014 | 326 | 2014 |
| The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor, ... Molecular cell 12 (6), 1427-1437, 2003 | 299 | 2003 |
| The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder H Walden, AJ Deans Annual review of biophysics 43, 257-278, 2014 | 267 | 2014 |
| Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 H Walden, MS Podgorski, BA Schulman Nature 422 (6929), 330-334, 2003 | 251 | 2003 |
| Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability KE Marshall, KL Morris, D Charlton, N O’Reilly, L Lewis, H Walden, ... Biochemistry 50 (12), 2061-2071, 2011 | 243 | 2011 |
| Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK 1‐dependent phosphorylation and activation A Kazlauskaite, RJ Martínez‐Torres, S Wilkie, A Kumar, J Peltier, ... EMBO reports 16 (8), 939-954, 2015 | 226 | 2015 |
| Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis A Kumar, JD Aguirre, TEC Condos, RJ Martinez‐Torres, VK Chaugule, ... The EMBO journal 34 (20), 2506-2521, 2015 | 181 | 2015 |
| Lack of prominent peptide–major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, ... Nature immunology 6 (4), 382-389, 2005 | 176 | 2005 |
| Tiny TIM: a small, tetrameric, hyperthermostable triosephosphate isomerase H Walden, GS Bell, RJM Russell, B Siebers, R Hensel, GL Taylor Journal of molecular biology 306 (4), 745-757, 2001 | 162 | 2001 |
| A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease DE Spratt, R Julio Martinez-Torres, YJ Noh, P Mercier, N Manczyk, ... Nature communications 4 (1), 1983, 2013 | 138 | 2013 |
| The CCP4 suite: integrative software for macromolecular crystallography J Agirre, M Atanasova, H Bagdonas, CB Ballard, A Baslé, ... Acta Crystallographica Section D: Structural Biology 79 (6), 449-461, 2023 | 134 | 2023 |
| RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns H Walden, K Rittinger Nature structural & molecular biology 25 (6), 440-445, 2018 | 132 | 2018 |
| Ubiquitin-like protein activation DT Huang, H Walden, D Duda, BA Schulman Oncogene 23 (11), 1958-1971, 2004 | 116 | 2004 |
| Selenium incorporation using recombinant techniques H Walden Acta Crystallographica Section D: Biological Crystallography 66 (4), 352-357, 2010 | 112 | 2010 |
| Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity A Kumar, VK Chaugule, TEC Condos, KR Barber, C Johnson, R Toth, ... Nature structural & molecular biology 24 (5), 475-483, 2017 | 100 | 2017 |
