Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8. 1 A Birkmann, K Mahr, A Ensser, S Yağuboğlu, F Titgemeyer, ... Journal of virology 75 (23), 11583-11593, 2001 | 242 | 2001 |
The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high … R Ebbert, A Birkmann, HJ Schüller Molecular microbiology 32 (4), 741-751, 1999 | 220 | 1999 |
Helicase–primase inhibitor pritelivir for HSV-2 infection A Wald, L Corey, B Timmler, A Magaret, T Warren, S Tyring, C Johnston, ... New England Journal of Medicine 370 (3), 201-210, 2014 | 156 | 2014 |
The immunogenic glycoprotein gp35-37 of human herpesvirus 8 is encoded by open reading frame K8. 1 MS Raab, JC Albrecht, A Birkmann, S Yağuboğlu, D Lang, ... Journal of virology 72 (8), 6725-6731, 1998 | 139 | 1998 |
HSV antivirals–current and future treatment options A Birkmann, H Zimmermann Current opinion in virology 18, 9-13, 2016 | 112 | 2016 |
Effect of pritelivir compared with valacyclovir on genital HSV-2 shedding in patients with frequent recurrences: a randomized clinical trial A Wald, B Timmler, A Magaret, T Warren, S Tyring, C Johnston, K Fife, ... Jama 316 (23), 2495-2503, 2016 | 83 | 2016 |
Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export and interaction with cellular receptors A Hahn, A Birkmann, E Wies, D Dorer, K Mahr, M Stürzl, F Titgemeyer, ... Journal of virology 83 (1), 396-407, 2009 | 81 | 2009 |
Mismatch primer-based PCR reveals that helicase–primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during … S Sukla, S Biswas, A Birkmann, P Lischka, H Zimmermann, HJ Field Journal of antimicrobial chemotherapy 65 (7), 1347-1352, 2010 | 39 | 2010 |
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro A Corcuera, K Stolle, S Hillmer, S Seitz, JY Lee, R Bartenschlager, ... Antiviral research 158, 135-142, 2018 | 37 | 2018 |
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes JT Schiffer, DA Swan, A Magaret, L Corey, A Wald, J Ossig, ... Science translational medicine 8 (324), 324ra15-324ra15, 2016 | 34 | 2016 |
Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase–primase inhibitor pritelivir HJ Field, ML Huang, EM Lay, I Mickleburgh, H Zimmermann, A Birkmann Antiviral research 100 (2), 297-299, 2013 | 33 | 2013 |
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis DC Quenelle, A Birkmann, T Goldner, T Pfaff, H Zimmermann, ... Antiviral research 149, 1-6, 2018 | 31 | 2018 |
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase–primase inhibitors, variously affect virus growth rate and pathogenicity S Biswas, LS Tiley, H Zimmermann, A Birkmann, HJ Field Antiviral research 80 (1), 81-85, 2008 | 27 | 2008 |
Effects of therapy using a helicase–primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant S Sukla, S Biswas, A Birkmann, P Lischka, H Ruebsamen-Schaeff, ... Antiviral research 87 (1), 67-73, 2010 | 22 | 2010 |
Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore S Kehlenbeck, U Betz, A Birkmann, B Fast, AH Goller, K Henninger, ... Journal of virology 80 (14), 6883-6894, 2006 | 21 | 2006 |
Lead development of thiazolylsulfonamides with carbonic anhydrase inhibitory action F Carta, A Birkmann, T Pfaff, H Buschmann, W Schwab, H Zimmermann, ... Journal of Medicinal Chemistry 60 (7), 3154-3164, 2017 | 19 | 2017 |
No evidence of pritelivir resistance among herpes simplex virus type 2 isolates after 4 weeks of daily therapy PT Edlefsen, A Birkmann, ML Huang, CA Magaret, JJ Kee, K Diem, ... The Journal of Infectious Diseases 214 (2), 258-264, 2016 | 17 | 2016 |
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes … S Biswas, S Sukla, T Goldner, HJ Field, D Kropeit, D Paulsen, A Welbers, ... Antimicrobial agents and chemotherapy 58 (7), 3843-3852, 2014 | 13 | 2014 |
Helicase–primase inhibitors as the potential next generation of highly active drugs against herpes simplex viruses A Birkmann, G Hewlett, H Rübsamen-Schaeff, H Zimmermann Future Virology 6 (10), 1199-1209, 2011 | 12 | 2011 |
Discovery, chemistry, and preclinical development of pritelivir, a novel treatment option for acyclovir-resistant Herpes simplex virus infections A Birkmann, S Bonsmann, D Kropeit, T Pfaff, M Rangaraju, M Sumner, ... Journal of Medicinal Chemistry 65 (20), 13614-13628, 2022 | 11 | 2022 |