Alexander Birkmann
Alexander Birkmann
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Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8. 1
A Birkmann, K Mahr, A Ensser, S Yağuboğlu, F Titgemeyer, ...
Journal of virology 75 (23), 11583-11593, 2001
The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high …
R Ebbert, A Birkmann, HJ Schüller
Molecular microbiology 32 (4), 741-751, 1999
Helicase–primase inhibitor pritelivir for HSV-2 infection
A Wald, L Corey, B Timmler, A Magaret, T Warren, S Tyring, C Johnston, ...
New England Journal of Medicine 370 (3), 201-210, 2014
The immunogenic glycoprotein gp35-37 of human herpesvirus 8 is encoded by open reading frame K8. 1
MS Raab, JC Albrecht, A Birkmann, S Yağuboğlu, D Lang, ...
Journal of Virology 72 (8), 6725-6731, 1998
HSV antivirals–current and future treatment options
A Birkmann, H Zimmermann
Current opinion in virology 18, 9-13, 2016
Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export and interaction with cellular receptors
A Hahn, A Birkmann, E Wies, D Dorer, K Mahr, M Stürzl, F Titgemeyer, ...
Journal of virology 83 (1), 396-407, 2009
Effect of pritelivir compared with valacyclovir on genital HSV-2 shedding in patients with frequent recurrences: a randomized clinical trial
A Wald, B Timmler, A Magaret, T Warren, S Tyring, C Johnston, K Fife, ...
Jama 316 (23), 2495-2503, 2016
Mismatch primer-based PCR reveals that helicase–primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during …
S Sukla, S Biswas, A Birkmann, P Lischka, H Zimmermann, HJ Field
Journal of antimicrobial chemotherapy 65 (7), 1347-1352, 2010
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes
JT Schiffer, DA Swan, A Magaret, L Corey, A Wald, J Ossig, ...
Science translational medicine 8 (324), 324ra15-324ra15, 2016
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro
A Corcuera, K Stolle, S Hillmer, S Seitz, JY Lee, R Bartenschlager, ...
Antiviral research 158, 135-142, 2018
Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase–primase inhibitor pritelivir
HJ Field, ML Huang, EM Lay, I Mickleburgh, H Zimmermann, A Birkmann
Antiviral research 100 (2), 297-299, 2013
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase–primase inhibitors, variously affect virus growth rate and pathogenicity
S Biswas, LS Tiley, H Zimmermann, A Birkmann, HJ Field
Antiviral research 80 (1), 81-85, 2008
Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore
S Kehlenbeck, U Betz, A Birkmann, B Fast, AH Goller, K Henninger, ...
Journal of virology 80 (14), 6883-6894, 2006
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis
DC Quenelle, A Birkmann, T Goldner, T Pfaff, H Zimmermann, ...
Antiviral research 149, 1-6, 2018
Effects of therapy using a helicase–primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant
S Sukla, S Biswas, A Birkmann, P Lischka, H Ruebsamen-Schaeff, ...
Antiviral research 87 (1), 67-73, 2010
Lead development of thiazolylsulfonamides with carbonic anhydrase inhibitory action
F Carta, A Birkmann, T Pfaff, H Buschmann, W Schwab, H Zimmermann, ...
Journal of medicinal chemistry 60 (7), 3154-3164, 2017
No evidence of pritelivir resistance among herpes simplex virus type 2 isolates after 4 weeks of daily therapy
PT Edlefsen, A Birkmann, ML Huang, CA Magaret, JJ Kee, K Diem, ...
The Journal of infectious diseases 214 (2), 258-264, 2016
Helicase–primase inhibitors as the potential next generation of highly active drugs against herpes simplex viruses
A Birkmann, G Hewlett, H Rübsamen-Schaeff, H Zimmermann
Future Virology 6 (10), 1199-1209, 2011
The product of the SNF2
R Ebbert, A Birkmann, HJ Schuller
SWI2 paralogue, 1999
Drugs in development for herpes simplex and varicella zoster virus
A Birkmann, H Zimmermann
Clinical Pharmacology & Therapeutics 102 (1), 30-32, 2017
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