| Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels K McCormack, S Santos, ML Chapman, DS Krafte, BE Marron, CW West, ... Proceedings of the National Academy of Sciences 110 (29), E2724-E2732, 2013 | 233 | 2013 |
| Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia L Cao, A McDonnell, A Nitzsche, A Alexandrou, PP Saintot, AJC Loucif, ... Science translational medicine 8 (335), 335ra56-335ra56, 2016 | 189 | 2016 |
| Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1. 7 in nociceptor electrogenesis, axonal conduction and presynaptic release AJ Alexandrou, AR Brown, ML Chapman, M Estacion, J Turner, MA Mis, ... PloS one 11 (4), e0152405, 2016 | 172 | 2016 |
| Mechanical load enhances the stimulatory effect of serum growth factors on cardiac fibroblast procollagen synthesis RP Butt, JE Bishop Journal of molecular and cellular cardiology 29 (4), 1141-1151, 1997 | 169 | 1997 |
| Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors. RP Butt, GJ Laurent, JE Bishop European journal of cell biology 68 (3), 330-335, 1995 | 160 | 1995 |
| Efficacy of the Nav1. 7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy A McDonnell, S Collins, Z Ali, L Iavarone, R Surujbally, S Kirby, RP Butt Pain 159 (8), 1465-1476, 2018 | 117 | 2018 |
| A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability CE Payne, AR Brown, JW Theile, AJC Loucif, AJ Alexandrou, MD Fuller, ... British journal of pharmacology 172 (10), 2654-2670, 2015 | 91 | 2015 |
| biology JB-E journal of cell, 1995 undefined R Butt, G Laurent Collagen production and replication by cardiac fibroblasts is enhanced in …, 0 | 88 | |
| Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis ML Hull, A Prentice, DY Wang, RP Butt, SC Phillips, SK Smith, ... Human Reproduction 20 (2), 350-358, 2005 | 86 | 2005 |
| Mechanical load and polypeptide growth factors stimulate cardiac fibroblast activity RP Butt, GJ Laurent, JE Bishop Annals of the New York Academy of Sciences-Paper Edition 752, 387-393, 1995 | 82 | 1995 |
| Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and … NA Swain, D Batchelor, S Beaudoin, BM Bechle, PA Bradley, AD Brown, ... Journal of Medicinal Chemistry 60 (16), 7029-7042, 2017 | 76 | 2017 |
| Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl) guanidines PV Fish, CG Barber, DG Brown, R Butt, MG Collis, RP Dickinson, ... Journal of medicinal chemistry 50 (10), 2341-2351, 2007 | 76 | 2007 |
| Inhibition of procollagen C‐proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring RR Reid, JE Mogford, R Butt, A DeGiorgio‐Miller, TA Mustoe Wound repair and regeneration 14 (2), 138-141, 2006 | 76 | 2006 |
| Increased skin collagen extractability and proportions of collagen type III are not normalized after 6 months healing of human excisional wounds SP Robins, G Milne, A Duncan, C Davies, R Butt, D Greiling, IT James Journal of investigative dermatology 121 (2), 267-272, 2003 | 74 | 2003 |
| Potent and selective nonpeptidic inhibitors of procollagen C-proteinase PV Fish, GA Allan, S Bailey, J Blagg, R Butt, MG Collis, D Greiling, ... Journal of medicinal chemistry 50 (15), 3442-3456, 2007 | 73 | 2007 |
| Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF … SA Nickolls, R Gurrell, G van Amerongen, J Kammonen, L Cao, AR Brown, ... British journal of pharmacology 175 (4), 708-725, 2018 | 52 | 2018 |
| Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects P Siebenga, G van Amerongen, JL Hay, A McDonnell, D Gorman, R Butt, ... Clinical and translational science 13 (2), 318-324, 2020 | 38 | 2020 |
| The use of a battery of pain models to detect analgesic properties of compounds: A two‐part four‐way crossover study P Okkerse, G van Amerongen, ML de Kam, J Stevens, RP Butt, R Gurrell, ... British journal of clinical pharmacology 83 (5), 976-990, 2017 | 37 | 2017 |
| Clinical micro-dose studies to explore the human pharmacokinetics of four selective inhibitors of human Nav1. 7 voltage-dependent sodium channels HM Jones, RP Butt, RW Webster, I Gurrell, P Dzygiel, N Flanagan, ... Clinical pharmacokinetics 55, 875-887, 2016 | 36 | 2016 |
| A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain R Gurrell, P Dua, G Feng, M Sudworth, M Whitlock, DS Reynolds, RP Butt Pain 159 (9), 1742-1751, 2018 | 27 | 2018 |
