Antonio Llinąs
Antonio Llinąs
RIA iMed AstraZeneca
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Cited by
Cited by
Oxadiazoles in medicinal chemistry
J Boström, A Hogner, A Llinąs, E Wellner, AT Plowright
Journal of medicinal chemistry 55 (5), 1817-1830, 2012
Polymorph control: past, present and future
A Llinąs, JM Goodman
Drug Discovery Today 13 (5-6), 198-210, 2008
Solubility challenge: can you predict solubilities of 32 molecules using a database of 100 reliable measurements?
A Llinąs, RC Glen, JM Goodman
Journal of chemical information and modeling 48 (7), 1289-1303, 2008
Diclofenac solubility: independent determination of the intrinsic solubility of three crystal forms
A Llinas, JC Burley, KJ Box, RC Glen, JM Goodman
Journal of medicinal chemistry 50 (5), 979-983, 2007
Findings of the challenge to predict aqueous solubility.
AJ Hopfinger, EX Esposito, A Llinas, RC Glen, JM Goodman
Journal of chemical information and modeling 49 (1), 1-5, 2009
Predicting intrinsic aqueous solubility by a thermodynamic cycle
DS Palmer, A Llinąs, I Morao, GM Day, JM Goodman, RC Glen, ...
Molecular Pharmaceutics 5 (2), 266-279, 2008
Beyond size, ionization state, and lipophilicity: influence of molecular topology on absorption, distribution, metabolism, excretion, and toxicity for druglike compounds
Y Yang, O Engkvist, A Llinąs, H Chen
Journal of medicinal chemistry 55 (8), 3667-3677, 2012
Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality
KTN Alex Avdeef, Elisabet Fuguet, Antonio Llinąs, Clara Rąfols, Elisabeth ...
ADMET and DMPK 4 (2), 117, 2016
Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a behavioral and electrophysiological study
XQ Shu, A Llinas, LM Mendell
Pain 80 (3), 463-470, 1999
Discovery of a novel oral glucocorticoid receptor modulator (AZD9567) with improved side effect profile
L Ripa, K Edman, M Dearman, G Edenro, R Hendrickx, V Ullah, ...
Journal of Medicinal Chemistry 61 (5), 1785-1799, 2018
A new method for the reproducible generation of polymorphs: two forms of sulindac with very different solubilities
A Llinas, KJ Box, JC Burley, RC Glen, JM Goodman
Journal of Applied Crystallography 40 (2), 379-381, 2007
Solubility challenge revisited after ten years, with multilab shake-flask data, using tight (SD∼ 0.17 log) and loose (SD∼ 0.62 log) test sets
A Llinas, A Avdeef
Journal of Chemical Information and Modeling 59 (6), 3036-3040, 2019
Inhibitors of metallo-β-lactamase generated from β-lactam antibiotics
A Badarau, A Llinįs, AP Laws, C Damblon, MI Page
Biochemistry 44 (24), 8578-8589, 2005
Intramolecular general acid catalysis in the aminolysis of β-lactam antibiotics
A Llinįs, MI Page
Organic & Biomolecular Chemistry 2 (5), 651-654, 2004
Findings of the second challenge to predict aqueous solubility
A Llinas, I Oprisiu, A Avdeef
Journal of chemical information and modeling 60 (10), 4791-4803, 2020
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases
M Lemurell, J Ulander, S Winiwarter, A Dahlen, O Davidsson, ...
Journal of Medicinal Chemistry 58 (2), 897-911, 2015
Inactivation of Bacterial dd-Peptidase by β-Sultams
A Llinįs, N Ahmed, M Cordaro, AP Laws, JM Frere, M Delmarcelle, ...
Biochemistry 44 (21), 7738-7746, 2005
Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution
A Llinąs, JC Burley, TJ Prior, RC Glen, JM Goodman
Crystal Growth and Design 8 (1), 114-118, 2008
Potent and orally bioavailable inverse agonists of RORγt resulting from structure-based design
F Narjes, Y Xue, S von Berg, J Malmberg, A Llinas, RI Olsson, J Jirholt, ...
Journal of Medicinal Chemistry 61 (17), 7796-7813, 2018
Chemical reactivity of penicillins and cephalosporins. Intramolecular involvement of the acyl-amido side chain
A Llinįs, B Vilanova, J Frau, F Munoz, J Donoso, MI Page
The Journal of Organic Chemistry 63 (24), 9052-9060, 1998
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