| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 232 | 2019 |
| NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation L Andreeva, L David, S Rawson, C Shen, T Pasricha, P Pelegrin, H Wu Cell 184 (26), 6299-6312. e22, 2021 | 130 | 2021 |
| Structural basis for the inhibition of Polo-like kinase 1 J Xu, C Shen, T Wang, J Quan Nature structural & molecular biology 20 (9), 1047-1053, 2013 | 120 | 2013 |
| Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 Y Li, TM Fu, A Lu, K Witt, J Ruan, C Shen, H Wu Proceedings of the National Academy of Sciences 115 (43), 10845-10852, 2018 | 118 | 2018 |
| Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, ... Cell 184 (23), 5759-5774. e20, 2021 | 114 | 2021 |
| Molecular mechanism for NLRP6 inflammasome assembly and activation C Shen, A Lu, WJ Xie, J Ruan, R Negro, EH Egelman, TM Fu, H Wu Proceedings of the National Academy of Sciences 116 (6), 2052-2057, 2019 | 91 | 2019 |
| Crystal structure of human IRAK1 L Wang, Q Qiao, R Ferrao, C Shen, JM Hatcher, SJ Buhrlage, NS Gray, ... Proceedings of the National Academy of Sciences 114 (51), 13507-13512, 2017 | 68 | 2017 |
| Multiple domain interfaces mediate SARM1 autoinhibition C Shen, M Vohra, P Zhang, X Mao, MD Figley, J Zhu, Y Sasaki, H Wu, ... Proceedings of the National Academy of Sciences 118 (4), e2023151118, 2021 | 49 | 2021 |
| Mechanism of ubiquitin transfer promoted by TRAF6 TM Fu, C Shen, Q Li, P Zhang, H Wu Proceedings of the National Academy of Sciences 115 (8), 1783-1788, 2018 | 41 | 2018 |
| Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1 Y Cui, S Keles, LM Charbonnier, AM Julé, L Henderson, SC Celik, I Reisli, ... Journal of Allergy and Clinical Immunology 145 (1), 391-401. e8, 2020 | 32 | 2020 |
| Crystal structure of the death effector domains of caspase-8 C Shen, H Yue, J Pei, X Guo, T Wang, JM Quan Biochemical and Biophysical Research Communications 463 (3), 297-302, 2015 | 29 | 2015 |
| Higher-order assemblies in immune signaling: supramolecular complexes and phase separation S Xia, Z Chen, C Shen, TM Fu Protein & cell 12 (9), 680-694, 2021 | 28 | 2021 |
| Structural and mechanistic elucidation of inflammasome signaling by cryo-EM C Shen, H Sharif, S Xia, H Wu Current opinion in structural biology 58, 18-25, 2019 | 28 | 2019 |
| pH regulates potassium conductance and drives a constitutive proton current in human TMEM175 W Zheng, C Shen, L Wang, S Rawson, WJ Xie, C Nist-Lund, J Wu, Z Shen, ... Science advances 8 (12), eabm1568, 2022 | 25 | 2022 |
| Structure-based design of benzo [e] isoindole-1, 3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway H Yue, F Lu, C Shen, JM Quan Bioorganic Chemistry 61, 21-27, 2015 | 23 | 2015 |
| Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8 C Shen, J Pei, X Guo, L Zhou, Q Li, J Quan Scientific reports 8 (1), 16723, 2018 | 22 | 2018 |
| TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels W Zheng, S Rawson, Z Shen, E Tamilselvan, HE Smith, J Halford, C Shen, ... Neuron 111 (20), 3195-3210. e7, 2023 | 19 | 2023 |
| Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma T Du, Y Song, A Ray, X Wan, Y Yao, MK Samur, C Shen, J Penailillo, ... Blood, The Journal of the American Society of Hematology 141 (21), 2599-2614, 2023 | 10 | 2023 |
| Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA C Shen, Y Du, F Qiao, T Kong, L Yuan, D Zhang, X Wu, D Li, YD Wu Scientific reports 8 (1), 12965, 2018 | 5 | 2018 |
| Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation L Andreeva, L David, S Rawson, C Shen, T Pasricha, P Pelegrin, H Wu bioRxiv, 2021.09. 12.459968, 2021 | 4 | 2021 |
Hao WuAsa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical SchoolVerified email at crystal.harvard.edu
